A5026130540- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- interferon and immune responses
- Extracellular vesicles in disease
- Immune Response and Inflammation
- Circular RNAs in diseases
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Sirtuins and Resveratrol in Medicine
- Retinal and Optic Conditions
- Peripheral Neuropathies and Disorders
- Genetics and Neurodevelopmental Disorders
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Blood Pressure and Hypertension Studies
- Autoimmune Neurological Disorders and Treatments
- PARP inhibition in cancer therapy
- Neurological Disease Mechanisms and Treatments
- Immunotherapy and Immune Responses
- Diabetes Treatment and Management
- Ginseng Biological Effects and Applications
Hebei Medical University
2014-2025
Second Hospital of Hebei Medical University
2021-2025
Hospital of Hebei Province
2021-2023
Obstetrics and Gynecology Hospital of Fudan University
2023
Multiple sclerosis (MS) still maintains increasing prevalence and poor prognosis, while glucagon-like peptide-1 receptor (GLP-1R) agonists show excellent neuroprotective capacities recently. Thus, we aim to evaluate whether the GLP-1R agonist liraglutide (Lira) could ameliorate central nervous system demyelination inflammation.The therapeutic effect of Lira was tested on experimental autoimmune encephalitis (EAE) in vivo a microglia cell line BV2 vitro.Lira administration disease score EAE...
Multiple sclerosis (MS) is an autoimmune, inflammatory demyelinating disorder of the central nervous system. Accumulating evidence has underscored therapeutic potential bone marrow mesenchymal stem cells (BMSCs)-derived exosomes (BMSC-Exos) containing bioactive compounds in MS. Herein, current study sought to characterize mechanism BMSC-Exos harboring miR-367-3p both BV2 microglia by Erastin-induced ferroptosis and experimental autoimmune encephalomyelitis (EAE), a typical animal model...
Introduction Multiple sclerosis (MS) is a chronic and debilitating inflammatory disease of the central nervous system (CNS), characterized by demyelination neurodegeneration. Emerging evidence implicates neutrophils in MS pathogenesis, particularly through processes like neutrophil extracellular traps (NETs) formation degranulation, which may exacerbate inflammation autoimmunity. Methods RNA sequencing peripheral blood from patients healthy controls identified differentially expressed genes...
This case report aims to highlight the atypical presentation and management of a patient diagnosed with CASPR2-associated autoimmune encephalitis NF155 antibody-positive nodopathies (AN), initially presenting limb weakness hyponatremia. The was identified through clinical evaluation diagnostic testing including serum cerebrospinal fluid analysis, neuroimaging, nerve conduction studies. exhibited weakness, hyponatremia, cognitive abnormalities, peripheral involvement. Diagnostic revealed...
Purpose Sanjie Zhentong Capsule (SZC) is gradually becoming widely used in the treatment of endometriosis (EMs) and has demonstrated an excellent curative effect clinic. However, active components mechanisms remain unclear, further research needed to explore effects (SZC). Materials methods First, a drug target database capsule was established by consulting TCMSP related literature. An disease then GeneCards, OMIM Drug Bank databases. The overlapping genes SZC EMs were determined,...
Patients with multiple sclerosis (MS) are commonly accompanied by optic neuritis (ON) that causes retinal ganglion cell (RGC) death and even vision loss. Nicotinamide adenine dinucleotide (NAD+) can protect against apoptosis attenuate MS-triggered symptoms. However, the effect of NAD+ on ON remains unclear. Herein, experimental autoimmune encephalomyelitis (EAE) was established immunizing female C57BL/6 mice MOG35-55 peptide. To investigate prevention treatment, EAE received 250 mg/kg daily...
Experimental autoimmune encephalomyelitis (EAE) is an induced disease widely used as animal model for multiple sclerosis, which mainly characterized by demyelination, axonal loss, well neurodegeneration of central nervous system (CNS). T-helper (Th) 17 cell that generate interleukin-17 (IL-17) plays a key role in its pathogenesis. Their activity and differentiation are tightly regulated some cytokines transcription factors. Certain microRNAs (miRNAs) involved the pathogenesis various...
This study aimed to determine the correlation between B-lymphoid tyrosine kinase (BLK) polymorphism, mRNA gene expression of BLK, and NMOSD in a Chinese Han population.B-lymphoid expressed mainly B cells plays key role various autoimmune disorders. However, no studies have investigated association BLK polymorphisms with neuromyelitis optica spectrum disorder (NMOSD).Han population 310 subjects were recruited analyze three single nucleotide (rs13277113, rs4840568, rs2248932) under allele,...
Background and Objective Post-translational modifications of antibodies, with a specific focus on galactosylation, have garnered increasing attention in the context understanding pathogenesis therapeutic implications autoimmune diseases. However, comprehensive scope clinical significance antibody galactosylation Neuromyelitis Optica Spectrum Disorder (NMOSD) remain enigmatic.The primary aim this research was to discern disparities serum IgG levels between individuals acute stage NMOSD...
Duchenne muscular dystrophy (DMD) is a genetic muscle disorder characterized by progressive wasting associated with persistent inflammation. In this study, we aimed to identify auxiliary biomarkers and further characterize the immune microenvironment in DMD.Differentially expressed genes (DEGs) were identified between DMD normal tissues based on Gene Expression Omnibus (GEO) datasets. Bioinformatical analysis was used screen potential diagnostic signatures of which validated real-time...
Abstract Background Forkhead box P3 ( FOXP3 ) plays a critical role in the pathogenesis of autoimmune disorders. In present study, we genotyped three single-nucleotide polymorphisms, namely, rs2232365, rs3761548, and rs3761549, to determine relationship between polymorphisms neuromyelitis optica spectrum disorder (NMOSD) susceptibility among Northern Chinese Han population. Materials methods We single nucleotide at loci gene (rs2232365, rs3761549136) 136 NMOSD patients 224 healthy subjects...
Objective: This study aimed to investigate the protective effect and mechanism of Astragalus polysaccharide (APS) on autoimmune encephalomyelitis. Methods: C57BL/6 mice were randomly divided into blank control group, EAE APS intervention group (n=15/group). The Experimental Autoimmune Encephalomyelitis (EAE) mouse model was established by active immunization. pathological changes in spinal cord evaluated Hematoxylin-eosin (HE) Luxol Fast Blue (LFB) staining. number CD11b+ Gr-1+...