A5101340166- Neuroscience and Neuropharmacology Research
- Genomics, phytochemicals, and oxidative stress
- Neonatal and fetal brain pathology
- Tryptophan and brain disorders
- Anesthesia and Neurotoxicity Research
- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- Neuroinflammation and Neurodegeneration Mechanisms
- Epilepsy research and treatment
- Orthopaedic implants and arthroplasty
- Biochemical effects in animals
- Lymphoma Diagnosis and Treatment
- Sulfur Compounds in Biology
- Alzheimer's disease research and treatments
- Transcranial Magnetic Stimulation Studies
- Reproductive Biology and Fertility
- Animal Genetics and Reproduction
- Neurological Disease Mechanisms and Treatments
- Carbon and Quantum Dots Applications
- Advanced Memory and Neural Computing
- Advanced Manufacturing and Logistics Optimization
- Glutathione Transferases and Polymorphisms
- Mosquito-borne diseases and control
- Tea Polyphenols and Effects
- Traditional Chinese Medicine Analysis
Chongqing Medical University
2023-2025
Southwest Medical University
2024
Hebei Medical University
2012-2024
Second Hospital of Hebei Medical University
2013-2024
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2024
China Pharmaceutical University
2023-2024
Bristol-Myers Squibb (United States)
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023-2024
Affiliated Hospital of Southwest Medical University
2024
BACKGROUND Temporal lobe epilepsy (TLE) is the most common type of intractable in humans, and it often accompanied by cognitive impairment. In this study, we examined effects (-)-Epigallocatechin-3-gallate (EGCG) after SE on behavior rat lithium-pilocarpine model TLE. MATERIAL AND METHODS The rats were randomly divided into 3 groups: (1) control group, which 12 received no treatment); (2) (EP) 15 treated with saline status epilepticus (SE); (3) EP+EGCG EGCG (25 mg/kg/d, intraperitoneal) SE....
Objective To investigate the correlation between idiopathic neonatal hyperbilirubinemia and ductus venosus closure time to examine prenatal factors influencing DV in neonates.
Redox-responsive hydropersulfide prodrugs are designed to enable a more controllable and efficient (RSSH) supply thoroughly explore their biological therapeutic applications in oxidative damage. To obtain novel activation patterns triggered by redox signaling, we focused on NAD(P)H: quinone acceptor oxidoreductase 1 (NQO1), canonical antioxidant enzyme, NQO1-activated RSSH prodrugs. We also performed head-to-head comparison of two mainstream structural scaffolds with solid quantitative...
BACKGROUND:We investigated whether apigenin could mitigate myocardial reperfusion injury in rats, and a possible mechanism was proposed. MATERIAL AND METHODS:The I-R model established rats along with sham group as control, the expressions of microRNA-15b (miR-15b), JAK2, p-JAK2 myocardia 2 groups were detected. Apoptosis reactive oxygen species (ROS) also Rats divided into 3 vivo: 1I-R group, 2I-R+solvent 3I-R+apigenin group. Expression miR-15b, p-JAK2, STAT3, p-STAT3 ROS content, apoptosis,...
Abstract Background The safety and efficacy of transarterial chemoembolization plus molecular targeted therapy (MTT) combined with immune checkpoint inhibitors (ICIs) in primary liver cancer have been demonstrated. However, the evidence for TACE MTT ICIs treatment recurrent hepatocellular carcinoma (RHCC) is limited. Given excellent performance this combination regimen cancer, it necessary to evaluate RHCC. Methods A total 88 patients RHCC treated camrelizumab (TACE-TC group, n = 46) or...
Introduction: Central precocious puberty (CPP) is a prevalent endocrine disorder. Research has indicated that pubertal development linked to nutritional metabolism. Irisin, novel myokine/adipokine, been identified as potential predictor of CPP in girls. This study aims examine the relationship between serum irisin levels and boys. Material methods: An enzyme-linked immunosorbent assay (ELISA) was used measure 32 boys diagnosed with 33 prepubertal age-matched normal controls (NC). To assess...
Epilepsy, especially the medial temporal lobe epilepsy (TLE), can result in cognitive impairment. Low‑frequency repetitive magnetic stimulation (rTMS) has been verified to suppress neural excitability and reduce seizures. Given its potential modifying cortical activity, we aimed investigate impact on function context of epilepsy, a condition where use rTMS not extensively explored. However, influence yet investigated. Therefore, this study effects low‑frequency improvement epileptic rats....
STING is broadly implicated in diseases ranging from cancer, autoimmune disease, neurodegeneration to rare, monogenic diseases. 1 Early drug discovery campaigns focused on activation as a promising platform for cancer immunotherapy yet failed multiple clinical trials due lack of efficacy thus far. 2 Current research and development activities concentrate inhibition treating disease neuroinflammation. While the progression activators into clinic has been successful, inhibitors remain elusive....
Aim To evaluate the suitability of serum osteocalcin (OC) as a marker to distinguish between rapidly and non‐rapidly progressive central precocious puberty (RP‐CPP NRP‐CPP), well its potential assess growth rates following treatment with gonadotropin‐releasing hormone agonist (GnRHa). Methods Serum levels OC were measured using enzyme‐linked immunosorbent assays in girls diagnosed either RP‐CPP or NRP‐CPP normal control subjects. Receiver operating characteristic (ROC) curve analysis was...
Objective: This study aimed to investigate the protective effect and mechanism of Astragalus polysaccharide (APS) on autoimmune encephalomyelitis. Methods: C57BL/6 mice were randomly divided into blank control group, EAE APS intervention group (n=15/group). The Experimental Autoimmune Encephalomyelitis (EAE) mouse model was established by active immunization. pathological changes in spinal cord evaluated Hematoxylin-eosin (HE) Luxol Fast Blue (LFB) staining. number CD11b+ Gr-1+...