A5042894266- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Bone Metabolism and Diseases
- Wound Healing and Treatments
- Bone and Joint Diseases
- Protease and Inhibitor Mechanisms
- Silk-based biomaterials and applications
- Graphene and Nanomaterials Applications
- Electrospun Nanofibers in Biomedical Applications
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- RNA Interference and Gene Delivery
- Neuropeptides and Animal Physiology
- Extracellular vesicles in disease
- Tissue Engineering and Regenerative Medicine
- Pancreatitis Pathology and Treatment
- Inflammasome and immune disorders
- Orthopaedic implants and arthroplasty
- Periodontal Regeneration and Treatments
- Ubiquitin and proteasome pathways
- Radiomics and Machine Learning in Medical Imaging
- IL-33, ST2, and ILC Pathways
- Reproductive System and Pregnancy
- Osteoarthritis Treatment and Mechanisms
- MicroRNA in disease regulation
Ruijin Hospital
2020-2024
Shanghai Jiao Tong University
2022-2024
Wound repair involves a sophisticated process that includes angiogenesis, immunoregulation and collagen deposition. However, weak revascularization performance the lack of biochemical cues to trigger immunomodulatory function currently limit biomaterial applications for skin regeneration tissue engineering. Herein, we fabricate new bioactive polypeptide hydrogel (QK-SF) constituted by silk fibroin (SF) vascular endothelial growth factor mimetic peptide KLTWQELYQLKYKGI (QK) simultaneously...
Three dimension (3D) printed scaffolds have been shown to be superior in promoting tissue repair, but the cell-level specific regulatory network activated by 3D printing with different material components form a symbiosis niche not systematically revealed. Here, three typical scaffolds, including natural polymer hydrogel (gelatin-methacryloyl, GelMA), synthetic (polycaprolactone, PCL), and bioceramic (β-tricalcium phosphate, β-TCP), are fabricated explore regulating effect of symbiotic...
Abstract Bone homeostasis is maintained through a balance of bone formation by osteoblasts and resorption osteoclasts. Ubiquitin-specific proteases (USPs) are involved in regulating metabolism preserving or antagonizing resorption. However, the specific USPs that maintain orchestrating simultaneously poorly understood. Here, we identified USP26 as previously unknown regulator coordinates Mechanistically, stabilizes β-catenin to promote osteogenic activity mesenchymal cells (MSCs) impairs...
Osteoarthritis (OA) is the most common degenerative joint disease in world. Gene therapy based on delivering microRNAs (miRNAs) into cells has potential for treatment of OA. However, effects miRNAs are limited by poor cellular uptake and stability. Here, we first identify a type microRNA-224-5p (miR-224-5p) from clinical samples patients with OA that can protect articular cartilage degeneration further synthesize urchin-like ceria nanoparticles (NPs) load miR-224-5p enhanced gene Compared...
The formation of a calcified cartilaginous callus (CACC) is crucial during bone repair. CACC can stimulate the invasion type H vessels into to couple angiogenesis and osteogenesis, induce osteoclastogenesis resorb matrix, promote osteoclast secretion factors enhance ultimately achieving replacement cartilage with bone. In this study, porous polycaprolactone/hydroxyapatite-iminodiacetic acid-deferoxamine (PCL/HA-SF-DFO) 3D biomimetic developed using printing. structure mimic pores formed by...
Abstract Postmenopausal osteoporosis (PMO) is often accompanied by neuroendocrine changes in the hypothalamus, which closely associates with microbial diversity, community composition, and intestinal metabolites of gut microbiota (GM). With emerging role GM bone metabolism, a potential signal neuropeptide Y (NPY) mediated brain‐gut‐bone axis has come to light. Herein, it reported that exogenous overexpression NPY reduced formation, damaged microstructure, up‐regulated expressions...
Abnormal activation of pancreatic stellate cells (PSCs) plays a crucial role in the pathogenesis chronic pancreatitis (CP). Irisin, an exercise-induced hormone, has been shown to mitigate liver fibrosis by inhibiting hepatic cells. However, effect irisin CP not evaluated. This study aimed determine whether is protective CP. was induced 6 IP injections cerulein (50 μg/kg/body weight). HPSCs were treated with 5 ng/ml TGF-β1 as vitro experiment. Our results showed that repeated injection severe...
Abstract A fundamental understanding of inflammation and tissue healing suggests that the precise regulation inflammatory phase, both in terms location timing, is crucial for bone regeneration. However, achieving activation early without causing chronic while facilitating quick regression to promote regeneration continues pose challenges. This study reveals black phosphorus (BP) accelerates by building an osteogenic immunological microenvironment. BP amplifies acute pro‐inflammatory response...
Significance of endogenous mineralization in bone reconstruction is paramount, as it facilitates the accumulation calcium ions for tissue deposition. However, conventional 3D‐printed scaffolds lack capacity ion enrichment and mineralization, coupled with their low inductive activity. Inspired from development natural plant seeds, a biomimetic 3D printing scaffold developed by implanting photosensitive black phosphorus “bone seeds” (BS), guiding sequential process mirroring rooting...
Wound repair involves a sophisticated process that includes angiogenesis, immunoregulation and collagen deposition. However, weak revascularization performance the lack of biochemical cues to trigger immunomodulatory function currently limit biomaterial applications for skin regeneration tissue engineering. Herein, we fabricate new bioactive polypeptide hydrogel (QK-SF) constituted by silk fibroin (SF) vascular endothelial growth factor (VEGF) mimetic peptide KLTWQELYQLKYKGI (QK)...