A5022413671- Neonatal and fetal brain pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Wound Healing and Treatments
- Neonatal Respiratory Health Research
- 3D Printing in Biomedical Research
- Advanced battery technologies research
- Electrospun Nanofibers in Biomedical Applications
- Electrocatalysts for Energy Conversion
- Immune Response and Inflammation
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Preterm Birth and Chorioamnionitis
- Advanced Photocatalysis Techniques
- Osteoarthritis Treatment and Mechanisms
- Anesthesia and Neurotoxicity Research
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Neuroscience and Neuropharmacology Research
- Advanced Drug Delivery Systems
- Extracellular vesicles in disease
- Tendon Structure and Treatment
- Quantum Dots Synthesis And Properties
- Silk-based biomaterials and applications
- Neurogenesis and neuroplasticity mechanisms
Shandong Normal University
2023-2025
Ruijin Hospital
2020-2025
Shanghai Jiao Tong University
2020-2025
Fujian Agriculture and Forestry University
2025
Ocean University of China
2023
East China University of Science and Technology
2019-2023
Jiaxing University
2020-2021
Zhejiang Chinese Medical University
2020
Wuhan University of Technology
2018-2019
Wuhan University
2012-2018
A single-layer graphene–CdS quantum dot nanocomposite is synthesized by a one-step reaction from graphene oxide, and thus avoids the low-yield production aggregation of sheets. This new graphene-based material shows promising optoelectronic properties. Picosecond ultrafast electron transfer CdS dots to sheets has been observed time-resolved fluorescence spectroscopy.
Abstract Protein is the key composition of all tissues, which has also been widely used in tissue engineering due to its superior biocompatibility and low immunogenicity. However, natural protein usually lacks active functions such as vascularization, osteo‐induction, neural differentiation, limits further applications a functional biomaterial. Here, based on mimetic extracellular matrix feature bovine serum albumin, injectable polypeptide‐protein hydrogels with vascularization antibacterial...
Metal ions are important trace elements in the human body, which directly affect metabolism and regeneration of damaged tissues. For instance, advanced combination magnesium (Mg2+) bone repair materials make composite have function promoting vascular enhancing adhesion osteoblasts. Herein, inspired by magnets to attract metals, we utilized coordination reaction metal ion ligand construct a bisphosphonate-functionalized injectable hydrogel microsphere (GelMA-BP-Mg) could promote cancellous...
Abstract Microfluidic hydrogel microspheres have been broadly studied across a wide range of industries and applications, their use in the medical field, including control cells drug delivery, is increasing. The usual design these materials intended to enable efficient smart encapsulation and/or drugs which functionalities features are effectively controlled, lending itself some unique properties. These characteristics promote exchanges cooperation multiple disciplines boost development...
Introducing hydration layers to hydrogel microspheres (HMs) by coating the surface with liposomes can effectively reduce friction. However, lubrication be inactivated when coatings are damaged. To endow HMs ability form self-renewable and maintain cellular homeostasis, rapamycin-liposome-incorporating hyaluronic acid-based (RAPA@Lipo@HMs) were created using microfluidic technology photopolymerization processes. The RAPA@Lipo@HMs improve joint a smooth rolling mechanism continuously exposing...
Intestinal immune homeostasis and microbiome structure play a critical role in the pathogenesis progress of inflammatory bowel disease (IBD), whereas IBD treatment remains challenge as first-line drugs show limited therapeutic efficiency great side effect. In this study, colon-targeted adhesive core-shell hydrogel microsphere is designed fabricated by ingenious combination advanced gas-shearing technology ionic diffusion method, which can congregate on colon tissue regulating gut...
Abstract Macrophage immunotherapy is an emerging treatment strategy that modulates the immune system to promote wound healing. The functionality and regeneration of tissue depend on spatially temporally regulating biophysical biochemical microenvironmental with poorly understood mechanisms. Biomaterials are carefully crafted display deliver macrophage regulatory signals in a precise near‐physiological way, serving as powerful artificial microenvironments which explore direct fate...
In situ Raman spectroscopy studies indicate that the high-valent molybdate ions can promote generation of disordered NiOOH active species and protect catalysts from Cl − corrosion during seawater oxidation.
Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication. However, these be damaged by shear, resulting in decreased Here, a shear-responsive boundary-lubricated drug-loaded hydrogel is created incorporating celecoxib (CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid (HA) (CLX@Lipo@HA-gel). The cross-linked network enables the to get restructured response and HA matrix allows accumulation of internal liposome microreservoirs...
Abstract Chronic hyperglycemic damage is a major problem that undermines diabetic wound healing. By combining treatment and diagnosis together, blood glucose concentration can be monitored real‐time through medical imaging devices precise interventions carried out at the right time to promote repair. In this study, an injectable self‐healing hyaluronic acid hydrogel constructed using Schiff base reaction, nanoenzymes (GOx‐MnO 2 ) synthesized by condensation along with vascular endothelial...
Regulating macrophage activation precisely is crucial in treating chronic inflammation osteoarthritis (OA). However, the stable pro-inflammatory state and deep distribution of macrophages vivo pose a great challenge to treatment. In this study, inspired by innate immune, immune cell mobilized hydrogel microspheres were constructed microfluidic methods load chemokines, antibodies engineered membrane vesicles (sEVs) via covalent non-covalent junctions. The microspheres, based on mixture...
Three-dimensional porous NiCoP foam supported on Ni is a superb bifunctional electrocatalyst for overall seawater splitting, attaining large current density of 1000 mA cm −2 at low cell voltage 1.97 V with robust stability over 300 hours.
Subcellular mitochondria serve as sensors for energy metabolism and redox balance, the dynamic regulation of functional dysfunctional plays a crucial role in determining cells' fate. Selective removal at subcellular level can provide chondrocytes with to prevent degeneration, thereby treating osteoarthritis. Herein, achieve an ideal therapy, cartilage affinity peptide (WYRGRL)-decorated liposomes loaded mitophagy activator (urolithin A) were integrated into hyaluronic acid methacrylate...
Abstract The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized play an important role in homeostasis regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes holds promise as external intervention enhance synthesis...
Serotonin (5-HT) plays a key role in early brain development, and manipulation of 5-HT levels during this period can have lasting neurobiological behavioral consequences. It is unclear how perinatal exposure to drugs, such as selective serotonin reuptake inhibitors (SSRIs), impacts cortical neural network function what mechanism(s) may elicit the disruption normal neuronal connections/interactions. In article, we report on wiring organization after pre- postnatal SSRI citalopram. We show...
Although the central nervous system melanocortin is an important regulator of energy balance, role proopiomelanocortin (POMC) neurons in mediating chronic effects leptin on appetite, blood pressure, and glucose regulation unknown. Using Cre/loxP technology we tested whether receptor deletion POMC (LepR(flox/flox)/POMC-Cre mice) attenuates to increase mean arterial pressure (MAP), enhance use oxygen consumption, reduce appetite. LepR(flox/flox)/POMC-Cre, wild-type, LepR(flox/flox), POMC-Cre...