A5059940428- Bone Metabolism and Diseases
- Pharmacological Effects of Medicinal Plants
- Osteoarthritis Treatment and Mechanisms
- Hip and Femur Fractures
- Antimicrobial agents and applications
- Wound Healing and Treatments
- Graphene and Nanomaterials Applications
- Osteomyelitis and Bone Disorders Research
- Hip disorders and treatments
- Sirtuins and Resveratrol in Medicine
- Biochemical effects in animals
- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Adenosine and Purinergic Signaling
- Connective Tissue Growth Factor Research
- Tendon Structure and Treatment
- Pain Management and Opioid Use
- 3D Printing in Biomedical Research
- Advanced Nanomaterials in Catalysis
- Autophagy in Disease and Therapy
- Education and Social Development in Ukraine
- Polydiacetylene-based materials and applications
- Musculoskeletal pain and rehabilitation
- Hydrogels: synthesis, properties, applications
- Bone fractures and treatments
Affiliated Hospital of North Sichuan Medical College
2020-2025
Ruijin Hospital
2023
Shanghai Jiao Tong University
2023
Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication. However, these be damaged by shear, resulting in decreased Here, a shear-responsive boundary-lubricated drug-loaded hydrogel is created incorporating celecoxib (CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid (HA) (CLX@Lipo@HA-gel). The cross-linked network enables the to get restructured response and HA matrix allows accumulation of internal liposome microreservoirs...
Bone defects are a global public health problem. However, the available methods for inducing bone regeneration limited. The application of traditional Chinese herbs has gained popularity in recent years. β-ecdysterone is plant sterol similar to estrogen, that promotes protein synthesis cells; however, its function remains unclear. In this study, we investigated on osteoblast differentiation and vitro vivo. MC3T3-E1 cells were used test vitro. results Cell Counting Kit-8 assay suggested...
Critical bone defects pose a significant challenge in the realm of defect repair. During repair process, formation is crucial, as occurrence invasive tissue growth into defect, known fibrosis, also possibility. Excessive fibrosis can lead to "filling effect," wherein fibrous occupies area, thereby impeding and processes. Hence, regulating dynamic balance between osteogenesis pivotal effectively treat critical defects. To mitigate rapid rate at site, which may result failure, we have devised...
To compare the effectiveness of femoral neck system (FNS) and cannulate compression screw (CCS) in treatment fractures young middle-aged patients.The clinical data 82 patients with fracture treated between January 2018 September 2020 were retrospectively analyzed. They divided into FNS group (24 cases) CCS (58 according to different surgical methods. There was no significant difference two groups ( P>0.05) general such as gender, age, height, body mass, cause injury, complications, location,...
<title>Abstract</title> <bold>Background: </bold>Traditional antibiotics are often ineffective against biofilm-associated infections, and biofilm-induced macrophage immune evasion directly halts the wound healing process. Disrupting biofilms regulating functions critical to improving healing. <bold>Results:</bold> In this study, we synthesized g-C<sub>3</sub>N<sub>4</sub> with peroxidase (POD) enzyme activity via thermal polymerization copper alginate microspheres (CAM) gas cutting. These...
To investigate the effectiveness difference between bone transport with a locking plate (BTLP) and conventional Ilizarov/Orthofix fixators in treatment of tibial defect.The clinical data 60 patients fractures who met selection criteria January 2016 September 2020 were retrospectively analyzed, treated BTLP (BTLP group, n=20), Ilizarov fixator (Ilizarov n=23), or Orthofix (Orthofix n=17) for transport. There was no significant gender, age, cause injury, time from injury to admission, length...
Abstract BackgroundLipopolysaccharide (LPS), a bacteria product, plays an important role in orthopedic diseases. Drugs that inhibit LPS-induced osteoclastogenesis are urgently needed for the prevention of bone destruction.MethodsIn this study, we evaluated effect β-ecdysterone (β-Ecd), major component Chinese herbal medicines derived from root Achyranthes bidentata BI on vitro and explored mechanism underlying effects β-Ecd this.ResultsWe showed inhibited osteoclast formation precursor...
Abstract Gram-negative bacterial infection causes many bone diseases such as osteolysis, osteomyelitis and septic arthritis. Lipopolysaccharide (LPS), a bacteria product, played an important role in this process. Drugs that inhibited LPS-induced osteoclastogenesis were urgently needed for the prevention of destruction infective diseases. Marein, major bioactive compound Coreopsis.tinctoria , which possesses anti-oxidative, anti-inflammatory, anti-hypertensive, anti-hyperlipidemic...