A5088076750- Osteoarthritis Treatment and Mechanisms
- Neurobiology and Insect Physiology Research
- 3D Printing in Biomedical Research
- Hydrogels: synthesis, properties, applications
- Cancer-related molecular mechanisms research
- Advanced Memory and Neural Computing
- Bone Tissue Engineering Materials
- Extracellular vesicles in disease
- RNA modifications and cancer
- NF-κB Signaling Pathways
- Innovative Microfluidic and Catalytic Techniques Innovation
- Mesenchymal stem cell research
- Insect and Arachnid Ecology and Behavior
- Orthopaedic implants and arthroplasty
- Rheumatoid Arthritis Research and Therapies
- Graphene and Nanomaterials Applications
- RNA Research and Splicing
- Electrospun Nanofibers in Biomedical Applications
- Natural product bioactivities and synthesis
- RNA and protein synthesis mechanisms
- Cell Adhesion Molecules Research
- Ferroelectric and Negative Capacitance Devices
- Signaling Pathways in Disease
- Bioactive natural compounds
- MicroRNA in disease regulation
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020-2025
Chongqing Medical University
2020-2025
Institute of Automation
2023-2025
Chinese Academy of Sciences
2022-2025
University of Chinese Academy of Sciences
2023-2025
Beijing Academy of Artificial Intelligence
2025
Duke University
2021-2024
Chongqing Municipal Health Commission
2024
Qiqihar Medical University
2023
Qingdao University
2022
Spiking neural networks (SNNs) serve as a promising computational framework for integrating insights from the brain into artificial intelligence (AI). Existing software infrastructures based on SNNs exclusively support simulation or brain-inspired AI, but not both simultaneously. To decode nature of biological and create we present cognitive engine (BrainCog). This SNN-based platform provides essential infrastructure developing AI simulation. BrainCog integrates different neurons, encoding...
Inspired by the extracellular matrix (ECM), biomaterials have emerged as promising strategies in biomedical research and engineering domain, offering unique characteristics for tissue regeneration, drug delivery, therapeutic interventions, cellular investigations. The ECM, a dynamic network structure secreted various cells, primarily comprises diverse proteins capable of facilitating tissue-ECM signaling regulatory functions through its rich array bioactive substances multi-level structural...
Abstract Hydrogels, key in biomedical research for their hydrophilicity and versatility, have evolved with hydrogel microspheres (HMs) of micron‐scale dimensions, enhancing role minimally invasive therapeutic delivery, tissue repair, regeneration. The recent emergence nanomaterials has ushered a revolutionary transformation the field, which demonstrates tremendous potential targeted therapies, biological imaging, disease diagnostics. Consequently, integration advanced nanotechnology promises...
Hydrogels are hydrophilic polymers with high flexibility and elasticity, widely used in the field of bone tissue engineering. However, their low toughness insufficient mechanical strength have limited applications. Nanocomposite hydrogels flexible porous as well possess excellent biocompatibility strength, thus exhibiting a significant potential to be synthesized by chemically or physically crosslinking nanomaterials hydrogels, physical, chemical, biological properties can enhanced changing...
Bone morphogenetic protein 2 (BMP2) effectively induced mesenchymal stem cells (MSCs) osteogenic differentiation hold great potential for bone tissue engineering. However, a global mechanistic view of BMP2-induced MSCs remains to be fully elucidated. Here, human umbilical cord-derived (UC-MSCs) were with BMP2, three days and five later, total RNA extracted subjected RNA-sequencing (RNA-Seq) followed bioinformatic analysis. Osteogenic abilities evaluated Alkaline phosphatase (ALP) staining...
Osteoarthritis (OA) is a prevalent degenerative joint disease and current therapies are insufficient to halt its progression. Mesenchymal stem cells-derived extracellular vesicles (MSCs-EVs) offer promising therapeutic potential for OA treatment, their efficacy can be enhanced through strategic engineering approaches. Inspired by the immune memory of adaptive system, we developed an engineered strategy impart OA-specific MSCs-EVs. Using Luminex technology, inflammatory factors (IFN-γ, IL-6,...
Acute stress results from sudden short-term events, and individuals need to quickly adjust their physiological psychological re-establish balance. Chronic stress, on the other hand, in long-term burdens due continued existence of stressors, making it difficult for recover prone pathological symptoms. Both types can affect working memory change cognitive function. In this study, we explored impact acute chronic synaptic modulation using a biologically inspired, data-driven rodent prefrontal...
OPINION article Front. Digit. Health, 26 June 2020 | https://doi.org/10.3389/fdgth.2020.00005
Abstract Background Bone morphogenetic protein 2 (BMP2) is a promising chondrogenic growth factor for cartilage tissue-engineering, but it also induces robust endochondral ossification. Human synovial-derived mesenchymal stromal cells (hSMSCs) have attracted great interest due to their poor potential differentiation into osteogenic lineages. Smad7 plays significant in the In this study, we explored new method amplify BMP2-induced of hSMSCs by downregulating and applying cellular scaffold....
Abstract Despite the high prevalence of osteoarthritis (OA) in older populations, disease-modifying OA drugs (DMOADs) are still lacking. This study was performed to investigate effects and mechanisms small molecular drug salicin (SA) on progression. Primary rat chondrocytes were stimulated with TNF-α treated or without SA. Inflammatory factors, cartilage matrix degeneration markers, cell proliferation apoptosis markers detected at mRNA protein levels. Cell evaluated by EdU assays flow...
Fluorosis is still endemic in at least 25 countries around the world. In this study, we investigated effect of high fluoride intake on fracture healing. Our vitro experiments found that inhibited osteogenic and angiogenic differentiation MSCs a dose-dependent manner. By constructing bone model, influences by attenuating endochondral ossification angiogenesis. mechanism, clarified inhibits M2 rather than M1 area, which may contribute to delayed healing fracture. These findings provide an...
Abstract Lubricin, secreted primarily by chondrocytes, plays a critical role in maintaining the function of cartilage lubrication system. However, both external factors such as friction and internal like oxidative stress can disrupt this system, leading to osteoarthritis. Inspired lubricin, lubricating nanozyme, that is, Poly‐2‐acrylamide‐2‐methylpropanesulfonic acid sodium salt‐grafted aminofullerene, is developed restore system using an “In‐Out” strategy. The “Out” aspect involves reducing...
Spiking Neural Networks (SNNs) serve as an appropriate level of abstraction to bring inspirations from brain and cognition Artificial Intelligence (AI). Existing software frameworks separately develop SNNs-based simulation brain-inspired intelligence infrastructures. However, the community requires open-source platform that can simultaneously support building integrating computational models for AI at multiple scales. To enable scientific quest decode nature biological create AI, we present...