A5100420564- Orthopedic Infections and Treatments
- Venous Thromboembolism Diagnosis and Management
- Osteoarthritis Treatment and Mechanisms
- Foot and Ankle Surgery
- Acupuncture Treatment Research Studies
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Botulinum Toxin and Related Neurological Disorders
- Pancreatitis Pathology and Treatment
- Hip and Femur Fractures
- Traditional Chinese Medicine Studies
- Trigeminal Neuralgia and Treatments
- Liver Disease Diagnosis and Treatment
- Tendon Structure and Treatment
- Pelvic and Acetabular Injuries
- Uterine Myomas and Treatments
- Natural product bioactivities and synthesis
- Shoulder Injury and Treatment
- Blood transfusion and management
- Endometriosis Research and Treatment
- Lower Extremity Biomechanics and Pathologies
- Diabetic Foot Ulcer Assessment and Management
- Atrial Fibrillation Management and Outcomes
- Inflammasome and immune disorders
- Cancer, Lipids, and Metabolism
The Affiliated Yongchuan Hospital of Chongqing Medical University
2013-2024
Chongqing Medical University
2014-2024
Nanjing Medical University
2022-2024
National Center for Clinical Laboratories
2024
Jiangsu Province Hospital
2024
Tianjin University
2024
Deyang Stomatological Hospital
2024
Zunyi Medical University
2020-2023
Shanghai Sixth People's Hospital
2019-2023
Shanghai Changzheng Hospital
2023
Abstract INTRODUCTION: Intracranial hemangiopericytoma (HPC) is a malignant meningothelial tumor. Because of its rarity, few guidelines exist for optimal management. METHODS: University California at San Francisco patients managed intracranial HPC were compiled into single database based on retrospective review patient records. Univariate and multivariate regression was performed to determine factors that independently predicted treatment outcomes. RESULTS: A total 40 with treated from 1989...
Bone morphogenetic protein 2 (BMP2) is one of the key chondrogenic growth factors involved in cartilage regeneration. However, it also exhibits osteogenic abilities and triggers endochondral ossification. Effective chondrogenesis inhibition BMP2-induced osteogenesis ossification can be achieved by directing mesenchymal stem cells (MSCs) towards chondrocyte lineage with chodrogenic factors, such as Sox9. Here we investigated effects Sox9 on differentiation MSCs. We found exogenous...
Ginsenoside Rg3 (Rg3), one of the most potent components extracted from roots traditional Chinese herb Panax ginseng, has prominent roles in anti-tumor and anti-inflammation. However, applications against myocardial hypertrophy are not fully revealed.Transverse aortic constriction (TAC) was adopted to build model rats. The vitro induced by angiotensin II (Ang II) human cardiomyocyte cell line AC16 HCM, which were then treated with different doses Rg3. levels markers (ANP, BNP, β-MHC)...
Background/Aims: Joint cartilage defects are difficult to treat due the limited self-repair capacities of cartilage. Cartilage tissue engineering based on stem cells and gene enhancement is a potential alternative for repair. Bone morphogenetic protein 2 (BMP2) has been shown induce chondrogenic differentiation in mesenchymal (MSCs); however, maintaining phenotypes MSCs during repair since occurs along endochondral ossification pathway. In this study, hypoxia inducible factor, or (HIF)-1α,...
Inflammation and poor viability of chondrocytes result in the degradation cartilage as osteoarthritis (OA) progresses. The purpose present study was to investigate whether ursolic acid (UA) can protect alleviate OA. Following stimulation with tumor necrosis factor-α (TNF-α), 5 μM UA displayed no cytotoxicity reversed up-regulation inflammatory factors MMP13, IL-1β, IL-6 PTGS2, down-regulation cartilaginous genes/proteins type II collagen Aggrecan. RNA sequencing identified 533 common...
Abstract Chronic osteomyelitis is a prolonged persistent disease accompanied by bone destruction and sequestrum formation, it very difficult to treat. Antibiotic loaded polymethyl methacrylate (PMMA) has been used in clinical. However, when PMMA was implanted the body, deficiencies that non-biodegradable second operation needed. Here, we synthesize novel levofloxacin mesoporous silica microspheres/nano-hydroxyapatite/polyurethane composite scaffolds, evaluated therapeutic effect treating...
Lev/MSNs/n-HA/PU has been proved to be a novel scaffold material treat bone defect caused by chronic osteomyelitis. We have previously identified that this can effectively osteomyelitis Staphylococcus aureus in vivo. However, the potential mechanisms of antibacterial and osteogenic induction properties remain unclear. Thus, for osteogenesis property, immunohistochemistry, PCR, Western blot were performed detect expression markers. Furthermore, flow cytometry TUNEL applied analyze MC3T3-E1...
OBJECTIVE To prospectively examine intakes of folate, vitamin B6, and B12 in relation to diabetes incidence a large U.S. cohort. RESEARCH DESIGN AND METHODS A total 4,704 American adults aged 18–30 years without were enrolled 1985–1986 monitored until 2015–2016 the Coronary Artery Risk Development Young Adults (CARDIA) study. Dietary assessment was conducted by validated dietary history questionnaire at baseline, 1992–1993, 2005–2006. The cumulative average used analyses. Incident...
Abstract Despite the high prevalence of osteoarthritis (OA) in older populations, disease-modifying OA drugs (DMOADs) are still lacking. This study was performed to investigate effects and mechanisms small molecular drug salicin (SA) on progression. Primary rat chondrocytes were stimulated with TNF-α treated or without SA. Inflammatory factors, cartilage matrix degeneration markers, cell proliferation apoptosis markers detected at mRNA protein levels. Cell evaluated by EdU assays flow...
Macrophages (Mφs) play a crucial role in the pathological progression of osteoarthritis (OA) by regulating inflammation and tissue repair. Decreasing pro-inflammatory M1-Mφs increasing anti-inflammatory M2-Mφs can alleviate OA-related promote cartilage Apoptosis is natural process associated with A large number apoptotic bodies (ABs), type extracellular vesicle, are produced during apoptosis, this reduction inflammation. However, functions remain largely unknown. In study, we investigated...
The phosphatidylinositol 3-kinase(PI3K)/protein kinase B (Akt) pathway plays a key role in inflammation. However, the regulatory roles of PI3K/Akt severe acute pancreatitis (SAP) have not been elucidated. aim this study was to investigate impact wortmannin, inhibitor, on SAP rats through exposure sodium taurocholate (STC) after 3 h and 6 h. group found significant increase pancreas Akt expression, along with activation serum amylase, TNF-α, IL-1β, IL-6, histological aggravation....
Questions remain, mainly concerning whether tranexamic acid (TXA) is truly safe since all available trials were underpowered to identify clinically important differences. The objective of this study evaluate the safety TXA by using a novel technique—thromboelastography (TEG). A retrospective review was conducted on 359 consecutive patients who underwent primary total hip arthroplasty (THA) or knee (TKA) and received multiple-dose single-dose at tertiary academic center. TEG parameters,...
Abstract Many coating materials have been studied to prevent surgical site infections (SSIs). However, antibacterial on surfaces show weak adhesion using the traditional titanium (Ti) cage, resulting in low efficacy for preventing SSIs after spinal surgery. Herein, a 3D‐printed Ti cage combined with drug‐releasing system is developed situ drug release and bacteria killing, leading prevention of vitro vivo. First, designed prepared by Electron Beam Melting (EBM) method. Second, polyvinyl...
Triangulenes have attracted enormous interest in organic chemistry and materials science, but suffer from their high instability towards oxygen. Embedding heteroatoms into triangulenes provides a new class of ambient stable for various applications. However, [3]heterotriangulenes dominated the heteroatom-doped triangulenes, while higher homologues been rarely explored. In this work, we synthesize [4]heterotriangulene with three oxygen-boron-oxygen (OBO) segments incorporated zigzag edges....