A5011314031- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Immune cells in cancer
- Cerebrospinal fluid and hydrocephalus
- Intracranial Aneurysms: Treatment and Complications
- Facial Nerve Paralysis Treatment and Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Bone Tumor Diagnosis and Treatments
- Adrenal and Paraganglionic Tumors
- Growth Hormone and Insulin-like Growth Factors
- Surgical Simulation and Training
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Cerebral Venous Sinus Thrombosis
- Spinal Fractures and Fixation Techniques
- Complement system in diseases
- Artificial Intelligence in Healthcare and Education
- Traumatic Brain Injury and Neurovascular Disturbances
University of Southern California
2019-2025
Augusta University
2021-2025
University of California, San Francisco
2012-2023
Stanford University
2023
University of New England
2023
New England College
2023
University of Nevada, Las Vegas
2023
Thomas Jefferson University
2023
Baptist Hospital of Miami
2023
Baptist Health South Florida
2023
Gliomas are known to induce local and systemic immunosuppression, inhibiting T-cell-mediated cytotoxic responses tumor growth. Tumor-associated macrophages a significant component of the immune infiltrate in gliomas may express immunosuppressive surface ligands, such as B7-H1.Tumor peripheral blood samples from patients with glioblastoma (GBM) were analyzed by flow cytometry evaluate expression B7-H1 circulating tumor-infiltrating macrophages. Human monocytes healthy stimulated conditioned...
In 1957, Simpson published a seminal paper defining the risk factors for recurrence following surgical treatment of intracranial meningiomas. Given that Simpson's study was more than 50 years ago, preceding image guidance technology and MR imaging, authors reviewed their own experience with Grade I meningiomas to determine if grading scale is still relevant modern neurosurgical practice.From this cohort, evaluated all patients undergoing craniotomy resection histologically proven WHO...
Abstract BACKGROUND: Grade II and III meningiomas have higher rates of tumor recurrence than grade I after surgery and/or external irradiation. As the utility noninvasive treatments for brain tumors increases, it is becoming increasingly important to assess likelihood that a not benign before treatment initiation. Hence, authors reviewed large series their patients determine risk factors higher‐grade pathology, with particular interest paid location. METHODS: The 378 presenting at...
Abstract INTRODUCTION: Intracranial hemangiopericytoma (HPC) is a malignant meningothelial tumor. Because of its rarity, few guidelines exist for optimal management. METHODS: University California at San Francisco patients managed intracranial HPC were compiled into single database based on retrospective review patient records. Univariate and multivariate regression was performed to determine factors that independently predicted treatment outcomes. RESULTS: A total 40 with treated from 1989...
Avoidance of facial nerve palsy is one the major goals vestibular schwannoma (VS) microsurgery. In this study, we examined significance previously implicated prognostic factors (age, tumor size, extent resection and surgical approach) on post-operative function. We selected all VS patients from prospectively collected database (1984-2009) who underwent microsurgical as their initial treatment for histopathologically confirmed VS. The effect variables such approach, patient age rates...
With limited studies available, the correlation between extent of resection and tumor recurrence in vestibular schwannomas (VSs) has not been definitively established. In this prospective study, authors evaluated 772 patients who underwent microsurgical VSs to analyze association total rate.The selected all cases from a prospectively collected database as their initial treatment for histopathologically confirmed VS. Recurrence-free survival was analyzed using Kaplan-Meier analysis. The...
Object The authors previously published a systematic review of the English language literature regarding natural history untreated vestibular schwannomas (VSs). This analysis found that best predictor future hearing loss was tumor growth > 2.5 mm/year on serial imaging, factor doubled rate loss. In this paper present an prospectively collected outcomes in patients with VS from their institution confirms previous findings. Methods Clinical, radiographic, and audiometric data for all...
Seizures in the perioperative period are a well-recognized clinical entity setting of brain tumor surgery. At present, suitability antiepileptic prophylaxis patients following surgery is unclear, especially those without prior seizures. Given paucity tumor-type and site-specific data, authors evaluated incidence postoperative seizures with convexity meningiomas no seizures.The identified 180 preoperative history who underwent resection meningioma. Some received for 7 days postoperatively...
Object While the surgical and neurological risks of meningioma surgery have been reported, much less effort has devoted to studying rates serious medical complications following such a procedure. The authors performed review 834 patients who underwent craniotomy for at their institution analyzed rate major cardiac, pulmonary, renal, hepatic complications. Methods identified all between 1993 2007 meningioma. Clinical information was reconstructed using patient records, medication radiological...
The management of parasagittal and falcine meningiomas centers around the relationship between tumor venous anatomy superior sagittal sinus (SSS) bridging veins. present study aims to address surgical outcomes in a focused cohort these patients for which there is not clinical equipoise radiosurgery transcranial resection.The undergoing removal at authors' institution over an 18-year period were analyzed. Analysis was limited with large, symptomatic, or rapidly growing tumors, whom good...
OBJECTIVE Pituitary apoplexy is a clinical syndrome consisting of neurological and endocrine abnormalities secondary to hemorrhage or ischemia an underlying pituitary adenoma. The authors investigated whether there was significant difference in neurological, endocrine, nonneuroendocrine outcomes for patients with apoplexy, based on the time between symptom onset surgical intervention. METHODS retrospectively analyzed medical records 32 who had presented their institution acute subsequently...
Pituitary adenoma (PA) consistency, or texture, is an important intraoperative characteristic that may dictate operative dissection techniques and/or instruments used for tumor removal during endoscopic endonasal approaches (EEAs). The impact of PA consistency on surgical outcomes has yet to be elucidated.
Background and Purpose— Vasospasm after aneurysmal subarachnoid hemorrhage (SAH) remains a leading cause of death disability aneurysm rupture. Decreased availability nitric oxide (NO) may be crucial in its pathogenesis. We hypothesized that endothelial NO synthase ( eNOS ) polymorphisms determine susceptibility to vasospasm SAH patients. Methods— conducted prospective cohort study patients determined by cerebral angiography. genotyped 3 polymorphisms: an intron 4 variable-number...