A5103128600- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Head and Neck Surgical Oncology
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Pituitary Gland Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Brain Metastases and Treatment
- Facial Nerve Paralysis Treatment and Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Spinal Fractures and Fixation Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Bone Tumor Diagnosis and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Complement system in diseases
- Cerebral Venous Sinus Thrombosis
- Growth Hormone and Insulin-like Growth Factors
- Neural dynamics and brain function
- Adrenal and Paraganglionic Tumors
- Neuroblastoma Research and Treatments
- Fetal and Pediatric Neurological Disorders
Prince of Wales Hospital
2018-2023
Neuroscience Research Australia
2022-2023
China XD Group (China)
2022-2023
Johnson University
2022
Rutgers, The State University of New Jersey
2022
Yale University
2022
University of Oklahoma Health Sciences Center
2014-2021
University of Oklahoma
2011-2019
Oklahoma City University
2015-2019
Neurological Surgery
2004-2017
In 1957, Simpson published a seminal paper defining the risk factors for recurrence following surgical treatment of intracranial meningiomas. Given that Simpson's study was more than 50 years ago, preceding image guidance technology and MR imaging, authors reviewed their own experience with Grade I meningiomas to determine if grading scale is still relevant modern neurosurgical practice.From this cohort, evaluated all patients undergoing craniotomy resection histologically proven WHO...
The complement cascade has been implicated in ischemia/reperfusion injury, and recent studies have shown that inhibition is a promising treatment option for acute stroke. development of clinically useful therapies hindered, however, by insufficient understanding which subcomponents contribute to post-ischemic injury. To address this issue, we subjected mice deficient selected proteins (C1q, C3, C5) transient focal cerebral ischemia. Of the strains investigated, only C3-/- were protected, as...
Abstract BACKGROUND: Grade II and III meningiomas have higher rates of tumor recurrence than grade I after surgery and/or external irradiation. As the utility noninvasive treatments for brain tumors increases, it is becoming increasingly important to assess likelihood that a not benign before treatment initiation. Hence, authors reviewed large series their patients determine risk factors higher‐grade pathology, with particular interest paid location. METHODS: The 378 presenting at...
One response to randomized trials like the International Subarachnoid Aneurysm Trial has been adopt a "coil first" policy, whereby all aneurysms be considered for coiling, reserving surgery unfavorable or failed attempts. Surgical results with middle cerebral artery (MCA) have excellent, raising debate about respective roles of surgical and endovascular therapy.To review our experience MCA managed microsurgery as treatment first choice.Five hundred forty-three patients 631 were "clip 115...
BACKGROUND Many significant microsurgical series of patients with giant aneurysms predate changes in practice during the endovascular era. OBJECTIVE A contemporary surgical experience is presented to examine management relative earlier reports, establish role open microsurgery strategy, and quantify results for comparison evolving therapies. METHODS During a 13-year period, 140 141 were treated surgically. One hundred (71%) located anterior circulation, 41 posterior circulation. RESULTS...
Object Gamma Knife surgery (GKS) has evolved into a practical alternative to open microsurgical resection in the treatment of patients with vestibular schwannoma (VS). Hearing preservation rates GKS series suggest very favorable outcomes without possible acute morbidity associated microsurgery. To mitigate institutional and practitioner bias, authors performed an analytical review published literature on patients. Their aim was objectively characterize prognostic factors that contribute...
Despite an increased understanding of the biology malignant meningioma tumor progression, there is a paucity published clinical data on factors affecting outcomes following treatment for these lesions. The authors present largest case series to date dealing with tumors, providing analysis 63 patients.The identified all patients undergoing resection WHO Grade III tumors at their institution over 16-year period. They analyzed from patients, and performed Kaplan-Meier Cox regression analyses...
Abstract INTRODUCTION: Intracranial hemangiopericytoma (HPC) is a malignant meningothelial tumor. Because of its rarity, few guidelines exist for optimal management. METHODS: University California at San Francisco patients managed intracranial HPC were compiled into single database based on retrospective review patient records. Univariate and multivariate regression was performed to determine factors that independently predicted treatment outcomes. RESULTS: A total 40 with treated from 1989...
Craniopharyngiomas are locally aggressive tumors which typically focused in the sellar and suprasellar region near a number of critical neural vascular structures mediating endocrinologic, behavioral, visual functions. The present study aims to summarize compare published literature regarding morbidity resulting from treatment craniopharyngioma. We performed comprehensive search English language identify studies publishing outcome data patients undergoing surgery for Comparisons rates...
The tumor microenvironment in astrocytomas is composed of a variety cell types, including infiltrative inflammatory cells that are dynamic nature, potentially reflecting biology. In this paper the authors demonstrate characterization intratumoral infiltrate can distinguish high-grade glioblastoma from low-grade pilocytic astrocytoma.Tumor specimens ninety-one patients with either or astrocytoma were analyzed at University California, San Francisco. A systematic neuropathology analysis was...
The inferior frontal gyrus (IFG) is involved in the evaluation of linguistic, interoceptive, and emotional information. A detailed understanding its subcortical white matter anatomy could improve postoperative morbidity related to surgery around this gyrus. Through GQI-based fiber tracking validated by gross anatomical dissection as ground truth, we characterized tracts IFG based on relationships other well-known neuroanatomic structures. Diffusion imaging from Human Connectome Project for...
Standard therapy for newly diagnosed glioblastoma (GBM) is surgical resection, followed by concurrent radiotherapy and temozolomide chemotherapy. In this phase II clinical trial, the addition of an autologous heat-shock protein vaccine to standard was evaluated. Tumor-induced immunosuppression, mediated expression PD-L1 on tumor circulating immune cells, may impact efficacy vaccination. Expression peripheral myeloid cells evaluated first time as a predictor survival.
ABSTRACT The inferior fronto-occipital fasciculus (IFOF) is a large white matter tract of the human cerebrum with functional connectivity associated semantic language processing and goal-oriented behavior. However, little known regarding overall this tract. Recently, Human Connectome Project parcellated cortex into 180 distinct regions. In our other work, we have shown these various regions in relation to clinically applicable anatomy function. Utilizing Diffusion Spectrum Magnetic Resonance...
Although meningiomas are commonly found along the supratentorial convexity, risk profile associated with this subset of lesions in modern neurosurgical era is unknown.The authors retrospectively reviewed clinical course patients convexity treated during past 10 years. All had undergone MR imaging within 72 hours after surgery and at least 1 year follow-up. Patients multiple meningiomas, hemangiopericytomas, malignant or tumor-prone syndromes were excluded from analysis.Between 1997 2007, 141...