A5067286956- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Meningioma and schwannoma management
- Cerebral Venous Sinus Thrombosis
- Moyamoya disease diagnosis and treatment
- Vascular Procedures and Complications
- Spinal Fractures and Fixation Techniques
- Complement system in diseases
- Peripheral Artery Disease Management
- Neurological Disease Mechanisms and Treatments
- Central Venous Catheters and Hemodialysis
- S100 Proteins and Annexins
- Vascular Anomalies and Treatments
- Cerebrospinal fluid and hydrocephalus
- Aortic Disease and Treatment Approaches
- Barrier Structure and Function Studies
- Spinal Hematomas and Complications
Barrow Neurological Institute
2016-2025
St. Joseph's Hospital and Medical Center
2016-2025
Health and Education Research Management and Epidemiologic Services (United States)
2023
Neuroscience Institute
2022
Brigham and Women's Hospital
2022
Dignity Health
2019-2022
Barber-Nichols (United States)
2020-2021
American Association of Neurological Surgeons
2017-2021
University of Arizona
2021
University of Pittsburgh Medical Center
2014-2020
The complement cascade has been implicated in ischemia/reperfusion injury, and recent studies have shown that inhibition is a promising treatment option for acute stroke. development of clinically useful therapies hindered, however, by insufficient understanding which subcomponents contribute to post-ischemic injury. To address this issue, we subjected mice deficient selected proteins (C1q, C3, C5) transient focal cerebral ischemia. Of the strains investigated, only C3-/- were protected, as...
Background and Purpose— EmboTrap is a novel stent retriever designed to achieve rapid substantial flow restoration in acute ischemic stroke secondary large-vessel occlusions. Here, we evaluated EmboTrap’s safety efficacy compared with established retrievers. Methods— ARISE II (Analysis of Revascularization Ischemic Stroke With EmboTrap) was single-arm, prospective, multicenter study, comparing the device composite performance goal criterion derived using Bayesian meta-analysis from pivotal...
The widespread implementation of the embolic agent Onyx has changed endovascular management cerebral arteriovenous malformations (AVMs). Recent data suggest that outcomes following embolization and resection may have worsened in era. It been hypothesized there be increased complications with surgical aggressiveness patients treated Onyx. In this study authors analyzed their institutional experience treatment AVMs prior to after introduction determine factors associated periprocedural...
The present study was undertaken to determine the efficacy of coadministration fingolimod with alteplase in acute ischemic stroke patients a delayed time window.This prospective, randomized, open-label, blinded endpoint clinical trial, enrolling internal carotid artery or middle cerebral proximal occlusion within 4.5 6 hours from symptom onset. Patients were randomly assigned receive alone fingolimod. All underwent pretreatment and 24-hour noncontrast computed tomography (CT)/perfusion CT/CT...
Background and Purpose- Microglia are among the first cells to respond intracerebral hemorrhage (ICH), but mechanisms that underlie their activity following ICH remain unclear. IL (interleukin)-15 is a proinflammatory cytokine orchestrates homeostasis intensity of immune response central nervous system inflammatory events. The goal this study was investigate role IL-15 in injury. Methods- Using brain slices patients with ICH, we determined presence cellular source IL-15. A transgenic mouse...
Background and Purpose- The CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial) demonstrated equivalent composite outcomes between carotid endarterectomy (CEA) artery stenting (CAS) for treating stenosis. We investigated nationwide trends in these procedures associated periprocedural stroke, myocardial infarction, death, cost, readmission rates since were published. Methods- queried the Nationwide Readmissions Database to identify patients undergoing CEA CAS asymptomatic...
Background The transradial artery (TRA) approach for neuroendovascular procedures continues to gain popularity, but neurointerventionalists still lag behind interventional cardiologists in the adoption of a TRA-first approach. This study compares complications and efficiency TRA standard transfemoral (TFA) at our institution during initial phase adopting Methods A retrospective analysis was performed on all consecutive neuroangiographic large cerebrovascular center from October 1, 2018 June...
Background Recently, middle meningeal artery (MMA) embolization has emerged as a potentially safe and effective method of treating chronic subdural hematoma (cSDH). Objective To report single-center experience with MMA examines the type embolic material used, extent penetration, number branches embolized. Methods A retrospective analysis all patients from 2018 through 2019 was performed. failed outcome defined either surgical rescue and/or greater than 10 mm residual or reaccumulation...
Background and Purpose— In patients identified at referring facilities with acute ischemic stroke caused by a large vessel occlusion, bypassing the emergency department (ED) direct transport to neuroangiography suite may safely shorten reperfusion times. Methods— We conducted single-center retrospective review of consecutive transferred our facility for consideration endovascular therapy. Patients were as admitted directly (DAN), ED before intra-arterial therapy (ED-IA), but did not receive...
Background Use of the Pipeline embolization device (PED) in posterior circulation is some controversy. Objective Recent publications have described adverse outcomes associated with PED for vertebral and/or basilar artery pathology. We assessed our results treatment this challenging subset aneurysms after Food and Drug Administration (FDA) approval. Methods prospectively reviewed series cases cohort. Patients were aneurysm type, technical success, periprocedural complications, obliteration....
In acute stroke due to large vessel occlusion, faster reperfusion leads better outcomes. We analyzed the effect of optimization steps aimed reduce treatment delays at our center.Consecutive patients with ischemic treated endovascular therapy were prospectively analyzed. divided into pre-optimization (20 April 2012 8 October 2013) and post-optimization (9 2013 29 July 2014) periods. The main interventions included: (1) continuous feedback; (2) standardized immediate emergency department...
Delayed cognitive decline commonly occurs following intracerebral hemorrhage (ICH), but the mechanisms underlying this phenomenon remain obscure. We therefore investigated potential responsible for impaired function in a mouse collagenase model of ICH. Following recovery motor and sensory deficits chronic phase ICH, we noted significant impairment, which was assessed by Morris water maze. This finding accompanied reduced dendrite spine density ipsilateral hippocampal CA1 neurons. Reduced...
Stent-assisted coil embolization using the new generation Neuroform Atlas Stent System has shown promising safety and efficacy. The primary study results of anterior circulation aneurysm cohort treatment wide-neck, saccular, intracranial, aneurysms with (ATLAS trial [Safety Effectiveness Treatment Wide Neck, Saccular Intracranial Aneurysms With System]) are presented.ATLAS IDE (Investigational Device Exemption) is a prospective, multicenter, single-arm, open-label wide-neck (neck ≥4 mm or...
OBJECTIVE Middle meningeal artery (MMA) embolization is a promising treatment strategy for chronic subdural hematomas (cSDHs). However, studies comparing MMA and conventional therapy (surgical intervention conservative management) are limited. The authors aimed to compare versus cSDHs using propensity-adjusted analysis. METHODS A retrospective study of all patients with cSDH who presented large tertiary center over 2-year period was performed. compared surgical management. Neurological...