A5036218021- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Immune cells in cancer
- Peripheral Artery Disease Management
- Neurological Complications and Syndromes
- Viral Infections and Vectors
- Neurological Disorders and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Renal and Vascular Pathologies
- Intracranial Aneurysms: Treatment and Complications
- Pulmonary Hypertension Research and Treatments
- Migraine and Headache Studies
- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Vector-borne infectious diseases
- Airway Management and Intubation Techniques
- Moyamoya disease diagnosis and treatment
- Cerebral Venous Sinus Thrombosis
- Pharmacological Effects and Toxicity Studies
- Cardiovascular and Diving-Related Complications
University of Pittsburgh
2018-2025
UPMC Health System
2018-2025
University of Pittsburgh Medical Center
2017-2024
Federal University of São João del-Rei
2024
United Nations Economic and Social Commission for Asia and the Pacific
2021-2024
University of Iowa Hospitals and Clinics
2021-2022
Barrow Neurological Institute
2017
Hospital de Messejana
2012
Universidade Federal do Rio Grande do Sul
2007
Efferocytosis, or phagocytic clearance of dead/dying cells by brain-resident microglia and/or infiltrating macrophages, is instrumental for inflammation resolution and restoration brain homeostasis after stroke. Here, we identify the signal transducer activator transcription 6/arginase1 (STAT6/Arg1) signaling axis as a potentially novel mechanism that orchestrates microglia/macrophage responses in ischemic brain. Activation STAT6 was observed microglia/macrophages territory mouse model...
The results of the DAWN trial (Diffusion-Weighted Imaging or Computerized Tomography Perfusion Assessment With Clinical Mismatch in Triage Wake Up and Late Presenting Strokes Undergoing Neurointervention Trevo) support benefit endovascular therapy patients presenting beyond 6-hour time window with anterior circulation large vessel occlusions. impact these respect to additional number eligible clinical practice remains unknown.A retrospective review ischemic stroke admissions a single...
Background and Purpose— In patients identified at referring facilities with acute ischemic stroke caused by a large vessel occlusion, bypassing the emergency department (ED) direct transport to neuroangiography suite may safely shorten reperfusion times. Methods— We conducted single-center retrospective review of consecutive transferred our facility for consideration endovascular therapy. Patients were as admitted directly (DAN), ED before intra-arterial therapy (ED-IA), but did not receive...
Background and Purpose- In the setting of acute ischemic stroke because large-vessel occlusion (LVO) there is progressive loss brain tissue which occurs in a time-dependent fashion previously quantified to be ≈1.9 million neurons per minute. However, this number represents an average accumulating evidence suggests large individual variation. study, we aim quantify distribution range rate across entire spectrum clinical phenotypes anterior circulation LVO strokes encountered practice....
Background and purpose The DAWN DEFUSE-3 trials demonstrated the benefit of endovascular thrombectomy (ET) in late-presenting acute ischemic strokes due to anterior circulation large vessel occlusion (ACLVO). Strict criteria were employed for patient selection. We sought evaluate characteristics outcomes patients treated outside these trials. Methods A retrospective review stroke admissions a single comprehensive center was performed during trial enrollment period (November 2014 February...
Background and Purpose- Fast slow progressors of infarct growth due to anterior circulation large vessel occlusion are commonly observed in clinical practice. We aimed estimate the prevalence temporal distribution fast among patients diagnosed within 24 hours stroke onset. Methods- Single-center retrospective study all with who underwent baseline computed tomographic perfusion or magnetic resonance imaging Prevalence was determined for (ischemic core >70 mL, <6 onset) ≤30 >6-24 onset)....
Background and Purpose- Microglia/macrophages (Mi/MΦ) can profoundly influence stroke outcomes by acquiring functionally dominant phenotypes (proinflammatory or anti-inflammatory; deleterious salutary). Identification of the molecular mechanisms that dictate functional status Mi/MΦ after brain ischemia/reperfusion may reveal novel therapeutic targets for stroke. We hypothesized activation TAK1 (transforming growth factor beta-activated kinase 1), a key MAP3K upstream multiple...
Senescence-associated alterations in microglia may have profound impact on cerebral homeostasis and stroke outcomes. However, the lack of a transcriptome-wide comparison between young aged context ischemia limits our understanding aging-related mechanisms. Herein, we performed RNA sequencing analysis purified from hemispheres adult (10-week-old) (18-month-old) mice five days after distal middle artery occlusion or sham operation. Considerable transcriptional differences were observed healthy...
Lymphocytes play an important role in the immune response after stroke. However, our knowledge of circulating lymphocytes ischemic stroke is limited. Herein, we collected blood samples clinical patients to detect change from admission 3 months by flow cytometry. A total 87 healthy controls and 210 were enrolled, percentages T cells, CD4 + CD8 double negative cells (DNTs), regulatory (Tregs), Tregs, B (Bregs) measured. Among patients, Bregs Tregs increased significantly, while dropped soon...
Background: Successful recanalization following endovascular thrombectomy (EVT) in vertebrobasilar artery occlusions (VBAOs) does not uniformly translate into favorable functional outcomes. Identifying predictors of futile is critical for improving patient selection and treatment strategies. This study aimed to compare patients with good versus poor outcomes despite successful VBAO establish predictive factors recanalization. Methods: We retrospectively analyzed who achieved after EVT from a...
Background: The effect of renal dysfunction on early infarct growth rate (IGR) in anterior circulation large vessel occlusion (ACLVO) stroke is not well studied. This study aimed to explore the association between creatinine-based biomarkers dysfunction, fast or slow progressor phenotypes ACLVO stroke, and related clinical outcomes. Methods: retrospective examined patients with acute intracranial internal carotid artery middle cerebral M1 occlusions admitted 2014 2019. Patients were included...
Background: Endovascular therapy (EVT) has emerged as a first-line intervention for vertebrobasilar artery occlusion (VBAO) patients, supported by two recent landmark randomized controlled trials. However, EVT outcomes may vary based on patient age and collateral status. This study examines the interaction between status in VBAO patients. Methods: We retrospectively analyzed patients who underwent from prospectively maintained database January 2014 2024. Patients were categorized into...
Introduction: Telestroke (TS) plays an important role in extending Vascular Neurology (VN) expertise. Minor acute ischemic stroke (AIS), defined as presentation National Institute of Health Stroke Scale (NIHSS) 0-5 accounts for majority AIS patients. Most studies evaluating Intravenous Thrombolysis (IVT) this population were performed utilizing in-person assessments by VN experts, and data surrounding IVT minor strokes TS platforms is lacking. Furthermore, determining the degree disability...
Blood monocytes/macrophages infiltrate the brain after ischemic stroke and critically influence injury regeneration. We investigated stroke-induced transcriptomic changes of by RNA sequencing profiling, using a mouse model permanent focal cerebral ischemia. Compared to non-ischemic conditions, ischemia induced only moderate genomic in blood monocytes, but triggered robust reprogramming invading brain. Surprisingly, functional enrichment analysis transcriptome macrophages revealed significant...
Imaging-based patient selection for neurothrombectomy is reliant on the identification of irreversibly damaged brain tissue (core) and salvageable (penumbra). The DAWN trial used clinical-core mismatch (CCM) paradigm (clinical deficit out proportion to infarct volume). We aim determine prevalence CCM in large vessel occlusion (LVO) strokes study impact time Alberta Stroke Program Early CT Score (ASPECTS) likelihood mismatch.We performed a retrospective observational analysis internal carotid...