A5102749787- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Spine and Intervertebral Disc Pathology
- Management of metastatic bone disease
- Intracranial Aneurysms: Treatment and Complications
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Cerebrovascular and Carotid Artery Diseases
- Cancer Immunotherapy and Biomarkers
- Neurofibromatosis and Schwannoma Cases
- Cerebrospinal fluid and hydrocephalus
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Tumors and Angiosarcomas
- Traumatic Brain Injury and Neurovascular Disturbances
- Healthcare Policy and Management
- Lanthanide and Transition Metal Complexes
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Pharmacogenetics and Drug Metabolism
- Adrenal and Paraganglionic Tumors
- Neurological Complications and Syndromes
- History of Medicine Studies
- Pituitary Gland Disorders and Treatments
Memorial Sloan Kettering Cancer Center
2020-2024
Louisiana State University Health Sciences Center Shreveport
2010-2022
University of Pittsburgh Medical Center
2015-2020
Neurological Surgery
2015-2019
University of Pittsburgh
2015-2016
University of Florida
2011
Louisiana State University Health Sciences Center New Orleans
2010
Louisiana State University
2010
George Washington University
1968-1978
Washington University Medical Center
1977
Incomplete coil occlusion is associated with increased risk of aneurysm recurrence. We hypothesize that intracranial stents can cause flow remodeling, which promotes further an incompletely coiled aneurysm.To study our hypothesis by comparing the follow-up angiographic outcomes stented and nonstented aneurysms.From January 2006 through December 2009, senior author performed 324 initial coilings previously untreated aneurysms, 145 were Raymond classification 2 3. Follow-up studies available...
Nivolumab is an immune checkpoint inhibitor (ICI) currently undergoing Phase III clinical trials for the treatment of glioblastoma. The authors present case a 10-year-old girl with glioblastoma treated nivolumab under compassionate-use guidelines. After first dose patient developed hemiparesis, cerebral edema, and significant midline shift due to severe tumor necrosis. She was managed using intravenous dexamethasone discharged on taper. patient's condition rapidly deteriorated after second...
Single doses of beta radiation ranging from 230 to 10000 rads were applied 35-cm² skin areas on the backs young male rats. The resultant dose-tumor incidence curves highly nonlinear: tumors all types increased abruptly at about 2000 rads, reached a peak 4000 and declined higher doses. sharp upturn in tumor formation occurred which prcduced mild moderate damage, while markedly pilocidal had suppressing effect adnexal tumors. There was shifting distribution with respect dose: hair follicle...
OBJECTIVE Comorbidities have an impact on risk stratification for outcomes in analyses of large patient databases. Although the Charlson Comorbidity Index (CCI) and Elixhauser (ECI) are most commonly used comorbidity indexes, these not been validated patients with unruptured cerebral aneurysms; therefore, authors created a index specific to patients. METHODS The extracted all records involving aneurysms treated clipping, coiling, or both from Nationwide Inpatient Sample (2002-2010). They...
Historically, symptomatic, benign intradural extramedullary (IDEM) spine tumors have been managed with surgical resection. However, minimal robust data regarding patient-reported outcomes (PROs) following treatment of symptomatic lesions exists. Moreover, there are increasing reports radiosurgical management these without health-related quality life data.To prospectively analyze PROs among patients IDEM undergoing resection to define the efficacy surgery.Prospective, single-center...
A reported because of its comparative rarity.T h e clinical course the disease in this patient was more rapid than those previously observed and autopsy revealed widespread organ involvement hitherto reported.T finding "myeloma kidneys," plus an abnormal component serum on electrophoresis, together with a picture acute leukemia, lends support to concept unity plasmacellular neoplasia. CASE REPORTY. G., 55-year-old retired white policeman, admitted January 4, 1951, diagnosis lymphosarcoma.He...
OBJECTIVE Frailty is one of the important factors in predicting outcomes surgery. Many surgical specialties have adopted a frailty assessment preoperative period for prognostication; however, there are limited data on effects cerebral aneurysms. The object this study was to find effect anterior circulation unruptured intracranial aneurysms (UIAs) and compare index with other comorbidity indexes. METHODS A retrospective performed utilizing National Inpatient Sample (NIS) database (2016–2018)....
Background: Leptomeningeal disease (LMD) from melanoma is rapidly fatal with median overall survival between 6.9 weeks and 3.5 months. It not known whether immune checkpoint inhibitors have a role in treating LMD. Case presentation: We report 33-year-old male patient who developed LMD BRAF V600E-mutated brain metastasis, despite prior treatment surgical resection, radiotherapy dabrafenib/trametinib. He underwent whole stereotactic to the lumbosacral spine, was started on nivolumab, which led...
OBJECTIVE Comorbidities have a significant effect on patient outcomes. Accounting for this is especially important in retrospective reviews of large databases; overpowered studies are at risk finding results because inaccurate stratification. The authors previously created neurovascular comorbidities index (NCI) patients with an unruptured intracranial aneurysm and found that the model’s ability to predict outcomes was statistically significantly improved over routinely used Charlson...
The literature suggests that minority racial and ethnic groups have lower treatment rates for unruptured intracranial aneurysms (UIA). It is uncertain how these disparities changed over time.A cross-sectional study using the National Inpatient Sample database covering 97% of USA population was carried out.A total 213 350 treated patients with UIA were included in final analysis compared 173 375 aneurysmal subarachnoid hemorrhage (aSAH) years 2000-2019. mean (SD) age aSAH 56.8 (12.6) 54.3...
OBJECTIVE Neurosurgery has remained relatively homogeneous in terms of racial and gender diversity, trailing behind national demographics. Less than 5% practicing neurosurgeons the United States identify as Black/African American (AA). Research academic productivity are highly emphasized within field crucial for career advancement at institutions. They also serve important avenues mentorship recruitment diverse trainees medical students. This study aimed to summarize accomplishments AA by...
Osteoblastomas are a rare, benign primary bone tumor accounting for 1% of all tumors, with 40% occurring within the spine. Gross-total resection (GTR) is curative, although depending on location, this can require destabilization spine and necessitate instrumented fixation. Through use minimally invasive, muscle-sparing approaches, these lesions be resected while maintaining structural integrity The authors present case report technical note single patient describing purely endoscopic...
Rats received a single dose of 10 mg 3-methylcholanthrene (MCA). Twenty-four hours later each rat 0.5 μCi 131I-labeled L-thyroxine (131I-T4). Bile was collected in hourly samples for 4 hr following 131I-T4. Average total (4 hr) biliary secretion 131I by MCA-treated rats approximately twice that control rats. volume flow rate bile not significantly different the two groups. During first hour collection, clearance plasma more than 3 times The major fraction both groups appeared to be T4-glucuronide.