A5012613674- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Melanoma and MAPK Pathways
- Cancer Mechanisms and Therapy
- Advanced Neuroimaging Techniques and Applications
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Pain Mechanisms and Treatments
- Meningioma and schwannoma management
- Lung Cancer Treatments and Mutations
- Diabetes Management and Research
- Fetal and Pediatric Neurological Disorders
- Diabetic Foot Ulcer Assessment and Management
- Radiopharmaceutical Chemistry and Applications
- Botulinum Toxin and Related Neurological Disorders
- Diabetes Treatment and Management
- Head and Neck Surgical Oncology
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Pituitary Gland Disorders and Treatments
- Chronic Disease Management Strategies
Memorial Sloan Kettering Cancer Center
2016-2025
Cornell University
2012-2024
Kettering University
2015-2024
Texas Tech University Health Sciences Center
2024
Texas Tech University
2024
George Washington University
2024
University Radiology
2023
Royal Liverpool University Hospital
2023
University of Liverpool
2023
Cambridge University Hospitals NHS Foundation Trust
2023
Five simple, noninvasive cardiovascular reflex tests have been used to assess autonomic function in one center over the past 10 yr. Seven hundred seventy-four diabetic subjects were tested for diagnostic and research purposes. In 543 completing all five tests, abnormalities of heart rate occurred 40%, while abnormal blood pressure less than 20%. Their results grouped as normal (39%), early (15%), definite (18%), severe (22%) involvement. Six percent had an atypical pattern results. Two...
To retrospectively determine whether relative cerebral blood volume (CBV) measurements can be used to predict clinical outcome in patients with high-grade gliomas (HGGs) and low-grade (LGGs) specifically who have a high initial CBV more rapid progression than those low CBV.Approval for this retrospective HIPAA-compliant study was obtained from the Institutional Board of Research Associates, waiver informed consent. One hundred eighty-nine (122 male 67 female patients; median age, 43 years;...
The prevalence of peripheral neuropathy, vascular disease, and foot ulceration in Type 2 diabetic patients the community were determined a community‐based study. Eight hundred eleven subjects (404 male, 407 female, mean age 65.4 (range 34–90) years, diabetes duration 7.4 (0–50) years) from 37 general practices three UK cities studied. Neuropathy was diagnosed clinically using modified neuropathy disability scores which ascertained structured interviews clinical examinations by one observer...
The objective response rate (ORR) for single-agent anti-programmed death receptor 1 (anti-PD-1) therapy is modest in patients with metastatic or recurrent head and neck squamous cell carcinoma (HNSCC). We aimed to test whether radiotherapy may act synergistically anti-PD-1 improve through the abscopal effect.We conducted a single-center, randomized, phase II trial of nivolumab (anti-PD-1 therapy) versus plus stereotactic body (SBRT) HNSCC. Patients had at least two lesions: one that could be...
Improving glycaemic control in people with Type 1 diabetes is known to reduce complications. Our aim was compare among using data gathered regional or national registries.Data were obtained for children and/or adults from the following countries (or regions): Western Australia, Austria, Denmark, England, Champagne-Ardenne (France), Germany, Epirus, Thessaly and Thessaloniki (Greece), Galway (Ireland), several Italian regions, Latvia, Rotterdam (The Netherlands), Otago (New Zealand), Norway,...
The BraTS 2021 challenge celebrates its 10th anniversary and is jointly organized by the Radiological Society of North America (RSNA), American Neuroradiology (ASNR), Medical Image Computing Computer Assisted Interventions (MICCAI) society. Since inception, has been focusing on being a common benchmarking venue for brain glioma segmentation algorithms, with well-curated multi-institutional multi-parametric magnetic resonance imaging (mpMRI) data. Gliomas are most primary malignancies central...
Diffuse gliomas are malignant brain tumors that include lower-grade (LGGs) and glioblastomas. Transformation of low-grade glioma into a higher tumor grade is typically associated with contrast enhancement on magnetic resonance imaging. Mutations in the isocitrate dehydrogenase 1 (IDH1) gene occur most LGGs (> 70%). Ivosidenib an inhibitor mutant IDH1 (mIDH1) under evaluation patients solid tumors.We conducted multicenter, open-label, phase I, dose escalation expansion study ivosidenib mIDH1...
The majority of WHO grades II and III gliomas harbor a missense mutation in the metabolic gene isocitrate dehydrogenase (IDH) accumulate metabolite R-2-hydroxyglutarate (R-2HG). Prior studies showed that this can be detected vivo using proton magnetic-resonance spectroscopy (MRS), but sensitivity methodology its clinical implications are unknown.We developed an MR imaging protocol to integrate 2HG-MRS into routine glioma examined performance 89 consecutive patients.Detection...
Abstract Purpose: Lower grade gliomas (LGGs) are malignant brain tumors. Current therapy is associated with short- and long-term toxicity. Progression to higher tumor contrast enhancement on MRI. The majority of LGGs harbor mutations in the genes encoding isocitrate dehydrogenase 1 or 2 (IDH1/IDH2). Vorasidenib (AG-881) a first-in-class, brain-penetrant, dual inhibitor mutant IDH1 IDH2 enzymes. Patients Methods: We conducted multicenter, open-label, phase I, dose-escalation study vorasidenib...
Photon involved-field radiotherapy (IFRT) is the standard-of-care for patients with leptomeningeal metastasis (LM) from solid tumors. We tested whether proton craniospinal irradiation (pCSI) encompassing entire CNS would result in superior progression-free survival (PFS) compared IFRT.
Of 208 young women with insulin dependent diabetes, 15 (7%) had a clinically apparent eating disorder (anorexia nervosa or bulimia), much higher prevalence than reported in non-diabetic women. Most, but not all, of these patients long history poor glycaemic control. In contrast previous suggestions, control did deteriorate after the onset disorder. There was high incidence and an early diabetic complications. Eleven retinopathy, six proliferative changes; nephropathy; neuropathy. Most...
To examine the potential utility of conventional MRI signs in differentiating pseudoprogression (PsP) from early progression (EP).This retrospective study reviewed initial postradiotherapy scans 321 patients with glioblastoma undergoing chemotherapy and radiotherapy. A total 93 were found to have new or increased enhancing mass lesions, raising possibility PsP. Final diagnosis PsP EP was established upon review surgical specimens a second resection by clinical radiologic follow-up. 11...
A double-blind, randomized, placebo-controlled cross-over trial of the aldose reductase inhibitor sorbinil was undertaken in 15 patients (age 35-68 yr) with chronic painful diabetic neuropathy. Treatment evaluated by subjective pain responses, clinical examination, vibration perception threshold, motor and sensory nerve electrophysiology, cardiovascular reflex tests autonomic function. Among many measurements, only pain, tendon scores, sural potential amplitude improved significantly during...
<h3>BACKGROUND AND PURPOSE:</h3> Treatment-related changes and recurrent tumors often have overlapping features on conventional MR imaging. The purpose of this study was to assess the utility DWI DSC perfusion imaging alone in combination differentiate treatment-related effects high-grade gliomas. <h3>MATERIALS METHODS:</h3> We retrospectively identified 68 consecutive patients with gliomas treated by surgical resection followed radiation therapy temozolomide, who then developed increasing...
Cerebral radiation necrosis (RN) is a difficult to treat complication of stereotactic radiosurgery (SRS) that can result in progressive neurologic decline. Currently, steroids are the standard care treatment for brain RN despite their adverse effect profile and limited efficacy. The purpose this study was evaluate efficacy cerebral bevacizumab patients with metastases previously treated SRS.We retrospectively reviewed 14 lesions 11 secondary SRS metastases. Steroid dosing, RN-associated...
Abstract Purpose: The genomic landscape of gliomas has been characterized and now contributes to disease classification, yet the relationship between molecular profile progression treatment response remain poorly understood. Experimental Design: We integrated prospective clinical sequencing 1,004 primary recurrent tumors from 923 glioma patients with phenotypes. Results: Thirteen percent harbored a pathogenic germline variant, including subset associated heritable genetic syndromes variants...