A5000592091- Diabetes Management and Research
- Diabetes and associated disorders
- Cystic Fibrosis Research Advances
- Pancreatic function and diabetes
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Diabetes Treatment and Management
- Ion Transport and Channel Regulation
- Diabetes Management and Education
- Chronic Disease Management Strategies
- Mobile Health and mHealth Applications
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Systems, Economic Evaluations, Quality of Life
- Respiratory viral infections research
- Clinical Nutrition and Gastroenterology
- Pneumonia and Respiratory Infections
- Immunodeficiency and Autoimmune Disorders
- Ion channel regulation and function
- Advanced Glycation End Products research
- Diet, Metabolism, and Disease
- Congenital Ear and Nasal Anomalies
- Asthma and respiratory diseases
- Obesity, Physical Activity, Diet
- Infant Nutrition and Health
- Magnesium in Health and Disease
IJsselland Ziekenhuis
2003-2010
Boston Children's Hospital
1995-2003
Pediatrics and Genetics
2001
Erasmus University Rotterdam
1990-2000
Erasmus MC - Sophia Children’s Hospital
1990-1998
The 65-kD isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes. We hypothesized that alum-formulated GAD65 (GAD-alum) can preserve beta-cell function patients with recent-onset diabetes.We studied 334 patients, 10 to 20 years age, diabetes, fasting C-peptide levels more than 0.3 ng per milliliter (0.1 nmol liter), and detectable serum autoantibodies. Within 3 months after diagnosis, were randomly assigned receive one three study treatments: four doses...
Improving glycaemic control in people with Type 1 diabetes is known to reduce complications. Our aim was compare among using data gathered regional or national registries.Data were obtained for children and/or adults from the following countries (or regions): Western Australia, Austria, Denmark, England, Champagne-Ardenne (France), Germany, Epirus, Thessaly and Thessaloniki (Greece), Galway (Ireland), several Italian regions, Latvia, Rotterdam (The Netherlands), Otago (New Zealand), Norway,...
Objective: The international SWEET registry (NCT04427189) was initiated in 2008 to improve outcomes pediatric diabetes. A 10-year follow-up allowed studying time trends of key quality indicators 22 centers from Europe, Australia, Canada, and India youth with type 1 diabetes (T1D). Methods: Aggregated data per person T1D <25 years age were compared between 2008-2010 2016-2018. Hierarchic linear logistic regression models applied. Models adjusted for gender, age-, duration groups. Results:...
Cystic fibrosis is the most common lethal autosomal recessive disorder among whites. Among Dutch patients with cystic fibrosis, ΔF508 mutation and A455E second of transmembrane conductance regulator gene on chromosome 7. associated preserved pancreatic function residual secretion chloride across membranes. We investigated whether it also less severe pulmonary disease in fibrosis.
To investigate the impact of chloride (Cl–) permeability, mediated by residual activity cystic fibrosis transmembrane conductance regulator (CFTR) or other Cl– channels, on manifestations (CF), we determined transport properties respiratory and intestinal tracts in ΔF508 homozygous twins siblings. In majority patients, cAMP and/or Ca2+-regulated was detected airways intestine. Our finding cAMP-mediated suggests that, vivo, at least some CFTR can reach plasma membrane affect permeability....
Previous Ussing chamber measurements of secretagogue-provoked changes in short circuit current rectal suction biopsies cystic fibrosis (CF) patients showed that a minority chloride secretion response to cholinergic agonists is reduced but not completely absent. To assess possible relationship between this phenomenon and both the genotype phenotype, we performed experiments on 51 CF patients. The mutation was identified 89 out 102 alleles. No apparent found 30 (group I). Low residual 11 II),...
To update and extend a previous cross-sectional international comparison of glycaemic control in people with type 1 diabetes.Data were obtained for 520,392 children adults diabetes from 17 population five clinic-based data sources countries or regions between 2016 2020. Median HbA1c (IQR) proportions individuals < 58 mmol/mol (<7.5%), 58-74 (7.5-8.9%) ≥75 (≥9.0%) compared populations aged <15, 15-24 ≥25 years. Logistic regression was used to estimate the odds ratio (OR) (<7.5%) relative ≥58...
Cystic fibrosis (CF), the most common severe autosomal recessive trait among Caucasians, is caused by molecular lesions in cystic transmembrane conductance regulator gene (CFTR). The course of multi-organ disease CF highly variable, suggesting influence environmental factors and/or modulating genes other than CFTR on phenotype. To evaluate cause variability, European Twin and Sibling Study collected data two clinical parameters sensitive for prognosis CF, ie weight predicted height (wfh)%...
To analyse blood glucose control according to continuous monitoring use in data from the CareLink database, and identify factors associated with continuation of sensor during sensor-augmented pump therapy.The analysis used 10 501 people Type 1 2 diabetes mellitus, whom 7916 (61.7%) had sensors for ≥ 15 days any 6-month period over a 2-year observation period. Data were analysed extent ( < 25%, 25-49%, 50-74% 75% time). Time discontinuation was also new users sensors.Compared patients lowest...
Background Frequent use of modern diabetes technologies increases the chance for optimal type 1 (T1D) control. Limited reimbursement influences access patients with T1D to these modalities and could worsen their prognosis. We aimed describe situation insulins, glucometers, insulin pumps (CSII) continuous glucose monitoring (CGM) children in European countries participating SWEET Project compare data from EU our previous study 2009. Methods The was conducted between March 2017 August 2017....
OBJECTIVE To analyze whether the coronavirus disease 2019 (COVID-19) pandemic increased number of cases or impacted seasonality new-onset type 1 diabetes (T1D) in large pediatric centers globally. RESEARCH DESIGN AND METHODS We analyzed data on 17,280 T1D diagnosed during 2018–2021 from 92 worldwide participating SWEET registry using hierarchic linear regression models. RESULTS The average per center adjusted for total patients treated at year and stratified by age-groups 11.2 (95% CI...
Abstract Background Innovations in diabetes technology have consistently improved outcomes of persons with type1 (PWDs). However, the volumes data that these technologies yield require different workflows to alleviate healthcare professionals’ (HCPs) workload and prevent losing relevant between visits for interpretation treatment adaptations. CloudCare is a population health management tool continuously oversees from groups individual PWDs, based on remote monitoring, screening triaging...
Background Seasonality at the clinical onset of type 1 diabetes (T1D) has been suggested by different studies, however, results are conflicting. This study aimed to evaluate presence seasonality T1D based on SWEET database comprising data from 32 countries. Methods The cohort included 23 603 patients (52% males) recorded in international multicenter (48 centers), with ≤20 years, year between 1980 and 2015, gender, month birth T1D-diagnosis documented. Data were stratified according four age...
Introduction Cardiovascular disease (CVD) is the leading cause of mortality in individuals with type 1 diabetes mellitus (T1DM). risk management therefore essential T1DM. This study describes performance lipid and blood pressure T1DM using three guidelines. Research design methods Individuals ≥18 years T1DM, treated insulin for ≥1 year, visiting Diabeter or University Medical Center Groningen between January 1, 2018 December 31, 2018, were included. Lipid examined Dutch, American Diabetes...
Purpose The ‘Biomarkers of heterogeneity in type 1 diabetes’ study cohort was set up to identify genetic, physiological and psychosocial factors explaining the observed disease progression development complications people with long-standing diabetes (T1D). Participants Data samples were collected two subsets. A prospective 611 participants aged ≥16 years ≥5 T1D duration from four Dutch Diabetes clinics between 2016 2021 (median age 32 years; median 12 59% female; mean glycated haemoglobin...
'SWEET' is an acronym standing for 'Better control in pediatric and adolescent diabeteS: Working to crEate CEnTers of Reference (CORs)' based on a partnership established national European diabetes organizations such as International Diabetes Federation, Federation Nurses Diabetes, Primary Care Europe (PCDE, www.sweet-project.eu). A three-level classification centers has been put forward. In addition local care, SWEET collaborating their way being COR have defined. Peer-audited CORs with...
<h3>Background:</h3> Knowledge of how <i>CFTR</i> mutations other than F508del translate into the basic defect in cystic fibrosis (CF) is scarce due to low incidence homozygous index cases. <h3>Methods:</h3> 17 individuals who are for deletions, missense, stop or splice site gene were investigated clinical symptoms CF and assessed CFTR function by sweat test, nasal potential difference intestinal current measurement. <h3>Results:</h3> activity gland, upper airways distal intestine was normal...