A5076471716- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Mobile Health and mHealth Applications
- Obesity, Physical Activity, Diet
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- Growth Hormone and Insulin-like Growth Factors
- Regulation of Appetite and Obesity
- Diabetes Management and Education
- Adolescent and Pediatric Healthcare
- Neuroblastoma Research and Treatments
- Health and Lifestyle Studies
- Child and Adolescent Health
- Thyroid Disorders and Treatments
- Congenital heart defects research
- Childhood Cancer Survivors' Quality of Life
- Asthma and respiratory diseases
- Cardiovascular Health and Disease Prevention
- Adipose Tissue and Metabolism
- Blood Pressure and Hypertension Studies
- Sexual Differentiation and Disorders
Vivantes Klinikum
2022-2025
Charité - Universitätsmedizin Berlin
2015-2024
Max Delbrück Center
2011-2024
Freie Universität Berlin
2013-2023
Humboldt-Universität zu Berlin
2017-2023
Gentofte Hospital
2019
Unfallkrankenhaus Berlin
2017
Klinik und Poliklinik für Kinder- und Jugendmedizin
2001-2008
Diabetes Australia
2008
Saarland University
2007
Approximately 10 percent of infants with intrauterine growth retardation remain small, and the causes their deficits are often unclear. We postulated that mutations in gene for insulin-like factor I receptor (IGF-IR) might underlie some cases prenatal postnatal failure.We screened two groups children abnormalities IGF-IR gene. In one group 42 patients unexplained subsequent short stature, we used single-strand conformation polymorphism analysis, followed by direct DNA sequencing any found. A...
M.P. has acted as scientific advisor for the development of glibenclamide-glyburide suspension named AMGLIDIA in European Union. The other authors have declared no conflicts interest.
To give an up-to-date profile of nephropathy and the involvement risk factors in a large, prospective cohort patients with type 1 diabetes largely pediatric adolescent onset disease.A total 27,805 from nationwide, German Diabetes Documentation System survey were included present analysis. Inclusion criteria at least two documented urine analyses identical classification. Urine analyses, treatment regimens, complications, recorded prospectively. Baseline characteristics age diagnosis 9.94...
Heterozygous coding mutations in the INS gene that encodes preproinsulin were recently shown to be an important cause of permanent neonatal diabetes. These dominantly acting prevent normal folding proinsulin, which leads beta-cell death through endoplasmic reticulum stress and apoptosis. We now report 10 different recessive 15 probands with Functional studies showed resulted diabetes because decreased insulin biosynthesis distinct mechanisms, including deletion, lack translation initiation...
Patient-driven initiatives have made uptake of Do-it-Yourself Artificial Pancreas Systems (DIYAPS) increasingly popular among people with diabetes all ages. Observational studies shown improvements in glycemic control and quality life adults diabetes. However, there is a lack research examining outcomes children adolescents DIYAPS everyday their social context.This survey assesses the self-reported clinical pediatric population using real world.An online was distributed to caregivers assess...
The aim of this study was to elucidate the entities and frequency neonatal diabetes mellitus (NDM) in a large representative database for paediatric patients Germany Austria.Based on continuous data acquisition system prospective surveillance (DPV), which includes 51,587 with onset before age 18 years from 299 centres Austria, we searched first 6 months life.Ninety were identified, comprising 0.17% all cases DPV registry. This represented an incidence approximately one case 89,000 live...
HNF1B-maturity-onset diabetes of the young is caused by abnormalities in HNF1B gene encoding transcription factor HNF-1beta. We aimed to investigate detailed clinical features and type anomaly five pediatric cases with HNF1B-MODY.From a cohort 995 children adolescents diabetes, we analyzed most frequent maturity-onset genes (GCK, HNF1A, HNF4A) including sequencing deletion analysis quantitative Multiplex-PCR Short Fluorescent Fragments (QMPSF) if patients were islet autoantibody-negative had...
Die Verbesserung der Versorgung von Kindern und Jugendlichen mit Diabetes mellitus ist eine wesentliche Aufgabe Arbeitsgemeinschaft für Pädiatrische Diabetologie (AGPD).
Background Automated insulin delivery (AID) systems have been shown to be safe and effective in reducing hyperglycemia hypoglycemia but are not universally available, accessible, or affordable. Therefore, user-driven open-source AID becoming increasingly popular. Objective This study aims investigate the motivations for which people with diabetes (types 1, 2, other) their caregivers decide build use a personalized AID. Methods A cross-sectional web-based survey was conducted assess personal...
To update and extend a previous cross-sectional international comparison of glycaemic control in people with type 1 diabetes.Data were obtained for 520,392 children adults diabetes from 17 population five clinic-based data sources countries or regions between 2016 2020. Median HbA1c (IQR) proportions individuals < 58 mmol/mol (<7.5%), 58-74 (7.5-8.9%) ≥75 (≥9.0%) compared populations aged <15, 15-24 ≥25 years. Logistic regression was used to estimate the odds ratio (OR) (<7.5%) relative ≥58...
To evaluate the relationship between media consumption habits, physical activity, socioeconomic status, and glycemic control in youths with type 1 diabetes.In cross-sectional study, self-report questionnaires were used to assess status 296 children, adolescents, young adults diabetes. Clinical data HbA(1c) levels collected. Risk factors analyzed by multiple regression.Youths diabetes (aged 13.7 ± 4.1 years, 8.7 1.6%, duration 6.1 3.3 years) spent 2.9 1.8 h per day watching television using...
OBJECTIVE ABCC8 mutations cause neonatal diabetes mellitus that can be transient (TNDM) or, less commonly, permanent (PNDM); ∼90% of individuals treated with oral sulfonylureas instead insulin. Previous studies suggested people ABCC8-PNDM require lower sulfonylurea doses and have milder neurological features than those KCNJ11-PNDM. However, these were short-term included combinations ABCC8-TNDM. We aimed to assess the long-term glycemic outcomes in sulfonylurea-treated ABCC8-PNDM. RESEARCH...
OBJECTIVES With this study, our aim was to quantify the relative risk (RR) of diabetic ketoacidosis at diagnosis type 1 diabetes during year 2020 and assess whether it associated with regional incidence coronavirus disease 2019 (COVID-19) cases deaths. METHODS Multicenter cohort study based on data from German Diabetes Prospective Follow-up Registry. The monthly RR for in estimated observed expected rates 3238 children new-onset diabetes. Expected were derived 2000 by using a multivariable...
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Signaling via the IGF-I receptor (IGF-IR) is crucial for normal prenatal and postnatal growth. The heterozygous IGF-IR mutation Arg59Ter resulted in reduced expression represents haploinsufficiency of human IGF1R gene.We studied clinical vitro aspects a gene dosage effect. We provide detailed data on two half-brothers their mother with mutation. control fibroblasts were examined functionality insulin-stimulated phosphorylation signal transduction.The brothers presented primary microcephaly,...