A5047296614- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Autoimmune and Inflammatory Disorders
- Muscle Physiology and Disorders
- Digestive system and related health
- Social Media in Health Education
- Nuclear Physics and Applications
- Metabolism and Genetic Disorders
- Protein Kinase Regulation and GTPase Signaling
- Japanese History and Culture
- Health Literacy and Information Accessibility
- Polyamine Metabolism and Applications
- Cutaneous lymphoproliferative disorders research
- Hidradenitis Suppurativa and Treatments
- Liver Disease Diagnosis and Treatment
- Emergency and Acute Care Studies
- Genetic Syndromes and Imprinting
- Autoimmune Bullous Skin Diseases
- Nonmelanoma Skin Cancer Studies
Children's Hospital of Philadelphia
2016-2025
University of Pennsylvania
2002-2024
Eastern Virginia Medical School
2021-2024
University of Toledo
2023
Hampton University
2022
Virginia Commonwealth University
2022
William & Mary
2022
Hospital of the University of Pennsylvania
1995-2021
Brown University
2003-2021
University of Pennsylvania Health System
2015-2019
▪ Objective: To determine whether glutamine-supplemented parenteral nutrition improves nitrogen retention and reduces hospital morbidity compared with standard after bone marrow transplantation. Design: Double-blind, randomized, controlled clinical trial. Setting: University teaching hospital. Patients: Forty-five adults receiving allogeneic transplants for hematologic malignancies. Intervention: Parenteral was initiated the day transplantation (day 1). The experimental solution supplemented...
Approximately 10 percent of infants with intrauterine growth retardation remain small, and the causes their deficits are often unclear. We postulated that mutations in gene for insulin-like factor I receptor (IGF-IR) might underlie some cases prenatal postnatal failure.We screened two groups children abnormalities IGF-IR gene. In one group 42 patients unexplained subsequent short stature, we used single-strand conformation polymorphism analysis, followed by direct DNA sequencing any found. A...
Significance Depression is disabling and treatable, but underdiagnosed. In this study, we show that the content shared by consenting users on Facebook can predict a future occurrence of depression in their medical records. Language predictive includes references to typical symptoms, including sadness, loneliness, hostility, rumination, increased self-reference. This study suggests an analysis social media data could be used screen individuals for depression. Further, may point clinicians...
To determine whether the impaired insulin-stimulated glucose uptake in obese individuals is associated with altered insulin receptor signaling, we measured both and early steps action pathway intact strips of human skeletal muscle. Biopsies rectus abdominus muscle were taken from eight control subjects undergoing elective surgery (body mass index 52.9 +/- 3.6 vs 25.7 0.9). Insulin-stimulated 2-deoxyglucose was 53% lower subjects. Additional incubated basal state or 10(-7) M for 2, 15, 30...
Little is known about how real-time online rating platforms such as Yelp may complement the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey, which US standard for evaluating patients’ experiences after hospitalization. We compared content narrative reviews hospitals to topics in HCAHPS called domains terminology. While included covered majority domains, an additional twelve not found HCAHPS. The that most strongly correlate with positive or negative are...
Glutamine is an important fuel utilized by the intestinal mucosa that not present in standard amino acid nutrition solutions. In order to determine effects of glutamine on intestine, enriched was administered intravenously male Wistar rats. A solution with 1 and 2 g/100 ml or glycine used as part a parenteral regime for 7 days. Intestinal samples were taken measurements jejunal weight, DNA, protein, mucosal thickness villus height. Animals receiving g glutamine/100 had increased height when...
A series of dose‐response studies was conducted to evaluate the clinical safety, pharmacokinetics, and metabolic effects L‐glutamine administered humans. Initial in normal individuals evaluated short‐term response oral loads glutamine at doses 0, 0.1, 0.3 g/kg. dose‐related increase blood occurred after loading elevation amino acids known be end products metabolism (including alanine, citrulline, arginine). No evidence toxicity or generation toxic metabolites (ammonia glutamate) observed....
The expression of insulin-like growth factor (IGF) receptors at the cell surface and changes in IGF responsiveness during differentiation were studied L6 skeletal muscle line.Throughout entire developmental sequence, distinct for I I1 that differed structure peptide specificity could be demonstrated.During differentiation, both 12'I-IGF 1261-IGF binding to cells decreased as a result 3-4-fold reduction receptor number, whereas 1251-insulin increased.Under nonreducing conditions,...
The binding of the eukaryotic initiation factor 4E (eIF4E) to mRNA 5' cap structure is a rate-limiting step in translation initiation. eIF4E promotes ribosome recruitment mRNA. In Drosophila, homologous protein (d4EHP) forms complex with partners suppress distinct mRNAs by competing for structure. This repression mechanism essential asymmetric distribution proteins and normal embryonic development Drosophila. contrast, physiological role mammalian 4EHP (m4EHP) was not known. this study, we...
The insulin-like growth factor I (IGF I) receptor is a tyrosine kinase-containing transmembrane protein that plays an important role in cell control. We have isolated and characterized human genomic DNA clones containing the entire coding sequence of IGF receptor. Results restriction analysis sequencing multiple overlapping were consistent with existence single gene. complete contained 21 exons. There striking homology insulin gene overall size (approximately 100 kilobases) number individual...
To test the hypothesis that glucocorticoid-induced insulin resistance might originate from abnormalities in receptor signaling, we investigated effects of glucocorticoids on vivo tyrosine phosphorylation and substrate IRS-1 rat skeletal muscle. Male Sprague-Dawley rats were treated with cortisone (100 mg/kg for 5 d) compared to pair-fed controls. Cortisone treatment resulted both hyperglycemia hyperinsulinemia. Anesthetized animals injected 10 U/kg via cardiac puncture and, after 2 min,...
<h3>Importance</h3> Patients with colorectal cancer liver metastases undergo hepatic resection curative intent. Positron emission tomography combined computed (PET-CT) could help avoid noncurative surgery by identifying patients occult metastases. <h3>Objectives</h3> To determine the effect of preoperative PET-CT vs no (control) on surgical management resectable and to investigate survival association between standardized uptake value (ratio tissue radioactivity injected adjusted weight)...
We studied whether medical conditions across 21 broad categories were predictable from social media content approximately 20 million words written by 999 consenting patients. Facebook language significantly improved upon the prediction accuracy of demographic variables for 18 disease categories; it was particularly effective at predicting diabetes and mental health including anxiety, depression psychoses. Social data are a quantifiable link into otherwise elusive daily lives patients,...
Insulin stimulates signaling reactions that include insulin receptor autophosphorylation and tyrosine kinase activation, substrate-1 (IRS-1) phosphorylation, phosphatidylinositol 3-kinase (PI 3-kinase) activation. Muscle contraction has metabolic effects similar to insulin, can increase sensitivity, but little is known about the molecular signals mediate of contraction. To investigate muscle on signaling, rats were studied after hindlimb muscles by electrical stimulation, maximal injection...
Glucose transport in insulin-regulated tissues is mediated by the GLUT4 and GLUT1 transporters. Using yeast two-hybrid system, we have cloned sentrin-conjugating enzyme mUbc9 as a protein that interacts with COOH-terminal intracellular domain. The was found to bind directly through an 11-aa sequence common two transporters modify both covalently conjugation substrate, sentrin. Overexpression of L6 skeletal muscle cells decreased transporter abundance 65%, resulting basal glucose transport....
Insulin-like growth factor-I (IGF-I) receptors activate divergent signaling pathways by phosphorylating multiple cellular proteins, including insulin receptor substrate-1 (IRS-1) and the Shc proteins. Following hormone binding, IGF-I cluster into clathrin-coated pits are internalized via an endocytotic mechanism. This study investigates relationship between internalization IRS-1 Shc. A mutation in C terminus of decreased both rate IGF-I-stimulated phosphorylation more than 50%, but did not...