A5013343091- Glaucoma and retinal disorders
- Cardiac electrophysiology and arrhythmias
- Retinal Development and Disorders
- Meat and Animal Product Quality
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Retinal Diseases and Treatments
- Stellar, planetary, and galactic studies
- Retinal Imaging and Analysis
- Animal Nutrition and Physiology
- Gamma-ray bursts and supernovae
- Mitochondrial Function and Pathology
- Astro and Planetary Science
- Astronomy and Astrophysical Research
- Neuroscience and Neural Engineering
- Cardiovascular Function and Risk Factors
- Muscle Physiology and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Optical Coherence Tomography Applications
- Cardiomyopathy and Myosin Studies
- Corneal surgery and disorders
- Cardiac Ischemia and Reperfusion
- Galaxies: Formation, Evolution, Phenomena
- Nuclear Receptors and Signaling
- Genetic and phenotypic traits in livestock
Cardiff University
2016-2025
Virginia–Maryland College of Veterinary Medicine
2025
Virginia Tech
2025
The University of Western Australia
2025
University Hospital of Wales
2010-2024
University of Wales
2000-2024
Bradford Royal Infirmary
2021-2024
Pathwest Laboratory Medicine
2023-2024
Hebrew SeniorLife
2024
Colorado Technical University
2024
A dramatic and specific induction of c-fos was observed in identifiable neuronal populations vivo after administration the convulsant Metrazole. This effect time- dose-dependent abolished by prior treatment with anticonvulsant drugs diazepam or pentobarbital. About 60 minutes Metrazole, messenger RNA reached a maximum declined to basal levels 180 minutes. further decrease below that normal brain before return 16 hours. While Metrazole still elicited seizures during this period, reinduction...
Intracellular Ca2+ release and reuptake are essential for contraction relaxation of normal heart muscle. transients were recorded with aequorin during isometric myocardium from patients end-stage failure. In contrast to controls, contractions muscles failing hearts markedly prolonged, the exhibited 2 distinct components. Muscles showed a diminished capacity restore low resting levels diastole. These experiments provide first direct evidence actively contracting human that intracellular...
The Pan-STARRS1 survey is collecting multi-epoch, multi-color observations of the sky north declination −30° to unprecedented depths. These data are being photometrically and astrometrically calibrated will serve as a reference for many other purposes. In this paper, we present our determination photometric system: gP1, rP1, iP1, zP1, yP1, wP1. system fundamentally based on Hubble Space Telescope Calspec spectrophotometric observations, which in turn models white dwarf atmospheres. We define...
P-glycoprotein (Pgp) affects the absorption, distribution, and clearance of a variety compounds. Thus, identification compounds that are Pgp substrates can aid drug candidate selection optimization. Our goal was to evaluate three assays used determine whether substrates. Sixty-six were tested in monolayer efflux, ATPase, calcein-AM assays. Assay results yielded two categories Category I (n = 35) exhibited concordance across II 31) revealed differences among related apparent permeability...
Fos and Jun form a heterodimeric complex that associates with the nucleotide sequence motif known as AP-1 binding site. Although this has been proposed to function transcriptional regulator in neurons, no specific target gene yet identified. Proenkephalin mRNA increased hippocampus during seizure just after an increase c-fos c-jun expression was detected. Fos-Jun complexes bound specifically regulatory 5' control region of proenkephalin gene. Furthermore, stimulated transcription from...
We studied the effects of different classes inotropic drugs on human working myocardium in vitro that was isolated from hearts patients with end-stage heart failure, and compared responses to these those noted muscles nonfailing control hearts. Although peak isometric force generated response increased extracellular calcium reached levels time course contraction rate relaxation were greatly prolonged. The effectiveness beta-adrenergic agonist isoproterenol phosphodiesterase inhibitors...
Alterations in proto-oncogene expression after stimulation of rat pheochromocytoma (PC12) cells by nerve growth factor (NGF) have been investigated. A specific c-fos messenger RNA and protein was detected 30 minutes treatment. This induction enhanced more than 100-fold the presence peripherally active benzodiazepines. The effect as very little change observed levels c-rasHa, c-rasKi, c-myc, N-myc RNA's. Under conditions used here, NGF treatment ultimately results neurite outgrowth, with a...
BACKGROUND The development of heart failure after acute myocardial infarction (MI) may be related to alterations left ventricular (LV) structure and function. Pathological LV remodeling exacerbate systolic diastolic dysfunction because increased cavity dimensions tend increase wall stress. Unfortunately, many complicating factors have made it difficult clearly define the time course in patients, contribution structural changes altered function has not been fully explored. METHODS AND RESULTS...
Software correlation, where a correlation algorithm written in high-level language such as C++ is run on commodity computer hardware, has become increasingly attractive for small to medium sized and/or bandwidth constrained radio interferometers. In particular, many long baseline arrays (which typically have fewer than 20 elements and are restricted observing by costly recording hardware media) utilized software correlators rapid, cost-effective correlator upgrades allow compatibility with...
Ataxia telangiectasia (AT) is characterized by progressive neurodegeneration that results from mutation of the ATM gene. However, neither normal function in nervous system nor biological basis degeneration AT known. Resistance to apoptosis developing central (CNS) Atm −/− mice was observed after ionizing radiation. This lack death occurred diverse regions CNS, including cerebellum, which markedly affected AT. In wild-type, but not mice, up-regulation p53 coincided with cell death, suggesting...
To determine the average tenderness and sensory ratings of beef subprimal cuts sold in retail cases across United States, were purchased through typical outlets 14 metropolitan cities transported to Texas A&M University for Warner-Bratzler shear analysis. The overall mean force all was 3.65 kg, values chuck, rib, loin, round 3.72, 3.36, 3.17, 4.31 respectively. No difference (P > .05) detected among from rib. Mean palatability top loin steaks similar those rib cuts. Top sirloin tougher <...
Our recent data show that in cardiac myocytes polyunsaturated fatty acids (PUFAs) are antiarrhythmic. They reduce I Na , shorten the action potential, shift threshold for excitation to more positive potentials, and prolong relative refractory period. In this study we use patch-clamp techniques whole-cell mode confocal Ca 2+ imaging examine effects of PUFAs on voltage-gated L-type current ( Ca,L ), elementary sarcoplasmic reticulum -release events (Ca -sparks), [Ca ] i transients isolated rat...
Aequorin was loaded into cells of the ferret portal vein in order to follow intracellular Ca2+ levels during smooth muscle contraction. In response a single d.c. pulse, aequorin signal reaches peak rising phase evoked force transient and begins rapidly fall while is still rising. addition phenylephrine bathing solution, rises but then falls lower level from which it declines more slowly, staying above base‐line as long maintained. elevation K+ concentration light rise together elevated...
We present a precise photometric calibration of the first 1.5 years science imaging from Pan-STARRS1 survey (PS1), an ongoing optical entire sky north declination −30° in five bands. Building on techniques employed by Padmanabhan et al. Sloan Digital Sky Survey (SDSS), we use repeat PS1 observations stars to perform relative each its bands, simultaneously solving for system throughput, atmospheric transparency, and large-scale detector flat field. Both internal consistency tests comparison...
As of 2012 January 21, the Pan-STARRS 1 3π Survey has observed 3/4 sky visible from Hawaii with a minimum 2 and mean 7.6 observations in five filters, gP1, rP1, iP1, zP1, yP1. Now at end second year mission, we are position to make an initial public release portion this unprecedented data set. This article describes PS1 Photometric Ladder, Release 12.01. is first series releases be generated as survey coverage increases analysis improves. The Ladder rungs every hour right ascension four...