A5072484694- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Gamma-ray bursts and supernovae
- Astronomy and Astrophysical Research
- Stellar, planetary, and galactic studies
- Astrophysics and Cosmic Phenomena
- Biomedical Research and Pathophysiology
- Genetic Syndromes and Imprinting
- Pulsars and Gravitational Waves Research
- Astrophysical Phenomena and Observations
- Hedgehog Signaling Pathway Studies
- Nuclear Physics and Applications
- Galaxies: Formation, Evolution, Phenomena
- Renal Diseases and Glomerulopathies
- Nuclear physics research studies
- Astronomical Observations and Instrumentation
- Astro and Planetary Science
- Pediatric Urology and Nephrology Studies
- Ion Transport and Channel Regulation
- Pancreatic function and diabetes
- Reproductive Biology and Fertility
- Fetal and Pediatric Neurological Disorders
- Renal cell carcinoma treatment
- Geophysics and Gravity Measurements
- Organ Donation and Transplantation
Medical College of Wisconsin
2009-2021
University of Hawaii System
2011-2020
Children's Hospital of Wisconsin
2005-2019
University of Hawaiʻi at Mānoa
2010-2017
Boston Children's Hospital
1984-2015
Trinity House
2013
Pediatrics and Genetics
2012
Newcastle University
2011
Case Western Reserve University
1996-2004
Rainbow Babies & Children's Hospital
1998-2004
Pan-STARRS1 has carried out a set of distinct synoptic imaging sky surveys including the $3π$ Steradian Survey and Medium Deep in 5 bands ($grizy_{P1}$). The mean 5$σ$ point source limiting sensitivities stacked 3$π$ $grizy_{P1}$ are (23.3, 23.2, 23.1, 22.3, 21.4) respectively. upper bound on systematic uncertainty photometric calibration across is 7-12 millimag depending bandpass. astrometric using Gaia frame comes from comparison results with Gaia: standard deviation median residuals ($...
We report extensive observational data for five of the lowest redshift Super-Luminous Type Ic Supernovae (SL-SNe Ic) discovered to date, namely PTF10hgi, SN2011ke, PTF11rks, SN2011kf and SN2012il. Photometric imaging transients at +50 +230 days after peak combined with host galaxy subtraction reveals a luminous tail phase four these SL-SNe. A high resolution, optical near infrared spectrum from xshooter provides detection broad He I $\lambda$10830 emission line in (+50d) SN2012il, revealing...
As of 2012 January 21, the Pan-STARRS 1 3π Survey has observed 3/4 sky visible from Hawaii with a minimum 2 and mean 7.6 observations in five filters, gP1, rP1, iP1, zP1, yP1. Now at end second year mission, we are position to make an initial public release portion this unprecedented data set. This article describes PS1 Photometric Ladder, Release 12.01. is first series releases be generated as survey coverage increases analysis improves. The Ladder rungs every hour right ascension four...
This paper describes the organization of database and catalog data products from Pan-STARRS1 $3\pi$ Steradian Survey. The are available in form an SQL-based relational MAST, Mikulski Archive for Space Telescopes at STScI. is described detail, including construction database, provenance data, schema, how tables related. Examples queries a range science goals included.
We present the details of photometric and astrometric calibration Pan-STARRS1 $3\pi$ Survey. The goals were to reduce systematic effects introduced by camera detectors, place all observations onto a system with consistent zero points over entire area surveyed, ~30,000 square degrees north $\delta$ = -30 degrees. compensates for similar so that positions, proper motions, parallaxes are reliable as well. Pan-STARRS Data Release 2 (DR2) astrometry is tied Gaia DR1 release.
We present griz light curves of 146 spectroscopically confirmed Type Ia Supernovae ($0.03 < z <0.65$) discovered during the first 1.5 years Pan-STARRS1 Medium Deep Survey. The natural photometric system is determined by a combination on-site measurements instrument response function and observations spectrophotometric standard stars. find that systematic uncertainties in are currently 1.2\% without accounting for uncertainty HST Calspec definition AB system. A Hubble diagram constructed with...
We present the discovery of three new Milky Way satellites from our search for compact stellar overdensities in photometric catalog Panoramic Survey Telescope and Rapid Response System 1 (Pan-STARRS 1, or PS1) 3pi survey. The first satellite, Laevens 3, is located at a heliocentric distance d=67+/-3 kpc. With total magnitude Mv=-4.4+/-0.3 half-light radius rh=7+/-2 pc, its properties resemble those outer halo globular clusters. second system, Draco II/Laevens 4 (Dra II), closer fainter...
A line of transgenic mice was generated that contains an insertional mutation causing a phenotype similar to human autosomal recessive polycystic kidney disease. Homozygotes displayed complex included bilateral kidneys and unusual liver lesion. The mutant locus cloned characterized through use the transgene as molecular marker. Additionally, candidate disease (PKD) gene identified whose structure expression are directly associated with locus. complementary DNA derived from this predicted...
Recent searches by unbiased, wide-field surveys have uncovered a group of extremely luminous optical transients. The initial discoveries SN 2005ap the Texas Supernova Search and SCP-06F6 in deep Hubble pencil beam survey were followed Palomar Transient Factory confirmation host redshifts for other similar transients share common properties high luminosities (peak magnitudes ∼−21 to −23), blue colors, lack H or He spectral features. physical mechanism that produces luminosity is uncertain,...
A consistent phenotype observed in both human patients and several different mouse models of autosomal recessive polycystic kidney disease (ARPKD) is an increased activity the epidermal growth factor receptor (EGFR) affected kidneys. To determine whether this EGFR a functional event that directly part pathway renal cyst formation, we used genetic approach to introduce mutant with decreased tyrosine kinase into murine model ARPKD. We found modified form could block increase EGFR-specific...
Despite identification of the genes responsible for autosomal dominant polycystic kidney disease (PKD) and recessive PKD (ARPKD), precise functions their cystoprotein products remain unknown. Recent data suggested that multimeric complexes initiate aberrant signaling cascades in PKD, common components these pathways may be therapeutic targets. This study identified c-Src (pp60(c-Src)) as one such intermediate sought to determine whether Src activity plays a role cyst formation. With use...
Autosomal-dominant polycystic kidney disease (ADPKD) is caused by mutations in either PKD1 or PKD2 and characterized the development of multiple bilateral renal cysts that replace normal tissue. Here, we used Pkd1 mutant mouse models to demonstrate nicotinamide adenine dinucleotide-dependent (NAD-dependent) protein deacetylase sirtuin 1 (SIRT1) involved pathophysiology ADPKD. SIRT1 was upregulated through c-MYC embryonic postnatal Pkd1-mutant epithelial cells tissues could be induced TNF-α,...
High-redshift quasars are currently the only probes of growth supermassive black holes and potential tracers structure evolution at early cosmic time. Here we present our candidate selection criteria from Panoramic Survey Telescope & Rapid Response System 1 follow-up strategy to discover in redshift range 5.7 ≲ z 6.2. With this discovered eight new ⩽ 6.0 quasars, increasing number known > by more than 10%. We additionally recovered 18 previously quasars. The presented here span a large...
The Pan-STARRS1 Science Consortium have carried out a set of imaging surveys using the 1.4 giga-pixel GPC1 camera on PS1 telescope. As this is composed many individual electronic readouts, and covers very large field view, great care was taken to ensure that instrumental effects were corrected produce most uniform detector response possible. We present image detrending steps used as part processing data contained within public release Data Release 1 (DR1). In addition single processing,...
The Pan-STARRS Data Processing System is responsible for the steps needed to downloaded, archive, and process all images obtained by telescopes, including real-time detection of transient sources such as supernovae moving objects potentially hazardous asteroids. With a nightly data volume up 4 terabytes an archive over petabytes raw imagery, solidly in realm Big astronomy. full processing system consists several subsystems covering wide range necessary capabilities. This article describes...
We probe the systematic uncertainties from 113 Type Ia supernovae (SNIa) in Pan-STARRS1 (PS1) sample along with 197 SN a combination of low-redshift surveys. The companion paper by Rest et al. (2013) describes photometric measurements and cosmological inferences PS1 sample. largest uncertainty stems calibration low-z samples. increase observed Calspec standards 7 to 10 used define system. SDSS-II systems are compared discrepancies up ~0.02 mag recovered. find proper way treat intrinsic...
Abstract Over 3 billion astronomical sources have been detected in the more than 22 million orthogonal transfer CCD images obtained as part of Pan-STARRS1 π survey. 85 instances those automatically and characterized by Pan-STARRS Image Processing Pipeline photometry software, psphot . This fast, automatic, reliable software was developed for project but is easily adaptable to from other telescopes. We describe analysis general well specific case third processing version used first two public...