A5104033468- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- MicroRNA in disease regulation
- Dementia and Cognitive Impairment Research
- COVID-19 Clinical Research Studies
- Functional Brain Connectivity Studies
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Berberine and alkaloids research
- Advanced Mathematical Identities
- Biomedical Research and Pathophysiology
- Alzheimer's disease research and treatments
- Liver physiology and pathology
- SARS-CoV-2 and COVID-19 Research
- Analytic Number Theory Research
- Mosquito-borne diseases and control
- Invertebrate Immune Response Mechanisms
- Advanced Neuroimaging Techniques and Applications
- dental development and anomalies
- Silicon Carbide Semiconductor Technologies
- Vector-borne infectious diseases
- Cytokine Signaling Pathways and Interactions
- Diamond and Carbon-based Materials Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced Combinatorial Mathematics
First Affiliated Hospital of Anhui Medical University
2020-2025
Anhui Medical University
2020-2025
Shihezi University
2011-2025
Daping Hospital
2012-2024
Mayo Clinic
2022-2024
Soochow University
2019-2024
Army Medical University
2012-2024
WinnMed
2022-2024
Zhejiang University
2006-2024
Mayo Clinic in Arizona
2021-2023
<h3>Importance</h3> Coronavirus disease 2019 (COVID-19) is an emerging infectious that was first reported in Wuhan, China, and has subsequently spread worldwide. Risk factors for the clinical outcomes of COVID-19 pneumonia have not yet been well delineated. <h3>Objective</h3> To describe characteristics patients with who developed acute respiratory distress syndrome (ARDS) or died. <h3>Design, Setting, Participants</h3> Retrospective cohort study 201 confirmed admitted to Wuhan Jinyintan...
No therapeutics have yet been proven effective for the treatment of severe illness caused by SARS-CoV-2.We conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes respiratory Covid-19, and an oxygen saturation (Sao2) 94% or less while they were breathing ambient air ratio partial pressure (Pao2) to fraction inspired (Fio2) than 300 mm Hg. Patients randomly assigned in 1:1 receive either lopinavir-ritonavir...
Silicon carbide (SiC) nanowires on a silicon substrate were prepared using hot-filament-assisted chemical-vapor deposition with solid and carbon source. The SiC show good field-emitting properties as revealed by the current–voltage characteristics. Together its ease of preparation, these are shown to have great potential in area electron devices.
Autosomal-dominant polycystic kidney disease (ADPKD) is caused by mutations in either PKD1 or PKD2 and characterized the development of multiple bilateral renal cysts that replace normal tissue. Here, we used Pkd1 mutant mouse models to demonstrate nicotinamide adenine dinucleotide-dependent (NAD-dependent) protein deacetylase sirtuin 1 (SIRT1) involved pathophysiology ADPKD. SIRT1 was upregulated through c-MYC embryonic postnatal Pkd1-mutant epithelial cells tissues could be induced TNF-α,...
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by renal cyst formation, inflammation, and fibrosis. Macrophages infiltrate cystic kidneys, but the role of these other inflammatory factors in progression are poorly understood. Here, we identified macrophage migration inhibitory factor (MIF) as an important regulator growth ADPKD. MIF was upregulated cyst-lining epithelial cells polycystin-1-deficient murine kidneys accumulated fluid human ADPKD kidneys. promoted cell...
Molecular tests revealed influenza D viruses of D/OK lineage widely circulating in farmed animal species Guangdong Province, southern China. In particular, we found high levels virus infection goats and pigs. We also detected viral RNA serum specimens feces animals with certain severe diseases.
<b><i>Background:</i></b> Early and accurate diagnosis of ischaemic stroke (IS) requires the use an optimized biomarker. Exosomal microRNAs have potential to serve as biomarkers owing their stability specificity. We investigated expression levels plasma-derived exosomal microRNA-21-5p microRNA-30a-5p in different phases IS. <b><i>Methods:</i></b> One hundred forty-three patients with IS 24 non-stroke controls were enrolled. The divided into...
A one-step procedure has been developed to grow β-SiC nanorods from a solid carbon and silicon source on Si substrate by hot filament chemical vapor deposition. This process is catalyzed metallic particles which come impurities in the plate made pressing mixture graphite powders at 150 °C. Hydrogen was introduced into reaction chamber react with produce hydrocarbon hydrosilicon radicals presumably reacted form SiC nanorods. The consisted of crystalline core an amorphous oxide shell layer...
The anti-malarial agent dihydroartemisinin (DHA) has strong anti-angiogenic activity. This study aimed to investigate the molecular mechanism underlying this effect of DHA on angiogenesis. We found that shows a dose-dependent inhibition proliferation and migration in HUVECs. specifically down-regulates mRNA protein expression VEGFR2 endothelial cells. Treatment with increases IκB-α blocks nuclear translocation NF-κB p65. In addition, directly regulates promoter activity through p65 binding...
Background: Differentiation of transient ischaemic attack (TIA) from stroke within the thrombolysis time window is difficult. Although TIA may be diagnosed this window, latest imaging technologies are complex and costly. Serum markers, which non-invasive, rapid economic, used for diagnosis prognosis various diseases. Exosome-derived miRNA markers unknown. Methods: We examined focal brain ischaemia produced by occlusion middle cerebral artery (MCAo) 5 min, 10 2 h in rats. Exosomal miRNAs with...
We present for the first time that histone deacetylase 6 (HDAC6) regulates EGFR degradation and trafficking along microtubules in Pkd1 mutant renal epithelial cells. HDAC6, microtubule-associated α-tubulin deacetylase, demonstrates increased expression activity mouse embryonic kidney Targeting HDAC6 with a general HDAC inhibitor, trichostatin (TSA), or specific tubacin, acetylation of downregulated was co-localized EGF induced endocytic endosomes, respectively. Inhibition accelerated from...
In this study, we identified a BET bromodomain (BRD) protein, Brd4, not only as novel epigenetic regulator of autosomal dominant polycystic kidney disease (ADPKD) but also client protein Hsp90. We found that Brd4 was upregulated in Pkd1 mutant mouse renal epithelial cells and tissues. This upregulation appears to result from the chaperone activity Hsp90 escape proteasomal degradation. further identify is an upstream expression c-Myc which has been all rodent models PKD ADPKD patients with...
Background: Immunological and inflammatory mechanisms play an important role in schizophrenia. The neutrophil-to-lymphocyte ratio (NLR) is a value obtained by dividing the absolute number of neutrophils lymphocyte count represents biomarker systemic response. There are studies investigating NLR association with psychopathology. However, relationship has been only studied small numbers patients schizophrenia, which leads to conflicting results makes meta-analytic data difficult interpret. aim...
The mechanisms underlying many of the human disease phenotypes associated with ciliary dysfunction and abnormal centrosome amplification have yet to be fully elucidated. Here, we present for first time that SIRT2, a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, regulates ciliogenesis amplification. Overexpression SIRT2 in renal epithelial cells appeared disrupt cilia formation, causing decreased numbers length, while inhibition activity by treatment or knockdown siRNA was...
Past efforts to pharmacologically disrupt the development and growth of renal cystic lesions focused primarily on normalizing activity a specific signaling molecule, but effects stimulating apoptosis in proliferating epithelial cells have not been well studied. Although benign, ADPKD cysts created by sustained proliferation resemble tumors, malignant cell death can be achieved cotreatment with TNF-α mimetic second mitochondria-derived activator caspase (Smac). Notably, accumulates high...