A5102006913- Neuroblastoma Research and Treatments
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Extracellular vesicles in disease
- Moyamoya disease diagnosis and treatment
- Inflammatory Biomarkers in Disease Prognosis
- Blood Coagulation and Thrombosis Mechanisms
- Generative Adversarial Networks and Image Synthesis
- Folate and B Vitamins Research
- Hereditary Neurological Disorders
- Neurological diseases and metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Hematopoietic Stem Cell Transplantation
- Angiogenesis and VEGF in Cancer
- Peripheral Neuropathies and Disorders
- Hydrogen's biological and therapeutic effects
- Ferroptosis and cancer prognosis
- Neurological Complications and Syndromes
- Viral Infections and Immunology Research
- T-cell and Retrovirus Studies
- Quantum-Dot Cellular Automata
- Nutrition and Health in Aging
Nanjing Medical University
2014-2025
Jiangsu Province Hospital
2014-2025
First Affiliated Hospital of GuangXi Medical University
2014-2024
Guangxi Medical University
2014-2024
Zhangzhou Normal University
2024
Northwestern Polytechnical University
2016-2020
Minzu University of China
2016
Background: Differentiation of transient ischaemic attack (TIA) from stroke within the thrombolysis time window is difficult. Although TIA may be diagnosed this window, latest imaging technologies are complex and costly. Serum markers, which non-invasive, rapid economic, used for diagnosis prognosis various diseases. Exosome-derived miRNA markers unknown. Methods: We examined focal brain ischaemia produced by occlusion middle cerebral artery (MCAo) 5 min, 10 2 h in rats. Exosomal miRNAs with...
Abstract Eltrombopag (EPAG) is an oral thrombopoietin receptor agonist analog with the potential risk to induce liver injury. This prospective registry study evaluated prevalence and severity of hepatic injury in Chinese patients severe aplastic anemia undergoing low-dose EPAG treatment (75 mg/day) context standard immunosuppressive therapy (IST). The incidence acute drug-induced was slightly higher IST + group than at 1st 2nd month, but no statistically significant difference observed: 10%...
Objective This study aims to identify factors influencing successful recanalization following endovascular intervention for non-acute basilar artery occlusion (NABAO). Background Endovascular treatment (EVT) is a feasible approach treating occlusion, but it presents significant technical challenges due the lack of standardized protocols. Therefore, identifying patients most likely benefit critical minimizing procedural risks. Methods A retrospective analysis was conducted on 115 with NABAO...
To investigate the effects of transplantation into rats with stroke bone marrow-derived mesenchymal stem cells (MSCs) induced by brain-derived neurotrophic factor (BDNF).MSCs were harvested from 6-week-old Sprague-Dawley male rats, and transplanted adult transient middle cerebral artery occlusion. At 48 hours after stroke, weighing 250-280 g, injected via tail vein 1×10(7) MSCs or BDNF (BDNF-MSCs) suspended in 1 ml phosphate-buffered saline. All animals underwent neurological function test...
Exosome-derived microRNAs (miRNAs) are potential diagnostic biomarkers. However, little is known about their effectiveness as biomarkers of intracranial aneurysms (IAs). This study aimed to explore miRNA levels in plasma exosomes patients with IA identify that predict the development and progress IA.
Genome-wide association studies (GWAS) have revealed numerous loci associated with multiple sclerosis (MS). However, the challenge lies in deciphering mechanisms by which these influence target traits. Here, we employed an integrative analytical pipeline to efficiently transform genetic associations identify novel proteins for MS. We systematically integrated MS GWAS data (N = 115,803) human plasma proteome 7213) and conducted proteome-wide (PWAS) MS-associated pathogenic proteins. Following...
Objectives The clinical and epidemiological profiles of Guillain-Barré syndrome (GBS) in southern China have yet to be fully recognised. We aimed investigate the subtypes GBS China, compare features demyelinating form with that axonal test whether preceding infections age influence on phenotype, disease course severity GBS. Methods Medical records patients a diagnosis admitted 31 tertiary hospitals, located 14 provinces from 1 January 2013 30 September 2016, were collected retrospectively...
Objective To identify the unique clinical features and biological markers of lung cancer-associated stroke. Methods We recruited 102 patients with cancer plus stroke, cancer, Detailed information was analysed compared among groups. Results The groups were age-matched. Patients stroke showed multiple lesions involving cerebral artery territories on magnetic resonance imaging, stroke-alone patients. These also had a poorer modified Rankin Scale score at 30 days, high mortality (18.6%). higher...
BACKGROUND:Stroke risk and stroke recurrence are increased in cancer patients, but the pathogenesis biomarkers of kidney cancer-related (KCS) generally unclear. The aim present research was to investigate plasma stroke. MATERIAL AND METHODS:A retrospective review conducted on acute patients with (KC) who were admitted hospital between January 2006 December 2015. A total 106 KCS (active KC without conventional vascular risks) identified. In addition, age- sex-matched alone recruited....
We designed a spatiotemporal generative adversarial network which given some initial data and random noise, generates consecutive sequence of samples that have logical relationship. build spatial discriminators temporal to distinguish whether the generated by generator meet requirements for time space coherence. The model is trained on skeletal dataset Caltrans Performance Measurement System District 7 dataset. In contrast traditional Generative networks (GANs), proposed GAN can generate...
Deficiency of protein C may cause deep venous thrombosis and pulmonary embolism, leading to ischemic stroke. The present study reports on a case young adult with recurrent cerebellar infarction due hereditary heterozygous deficiency performs literature review. A 35-year-old Asian woman was admitted t o the Department Neurology First Affiliated Hospital Guangxi Medical University (Nanning, China) right limb paralysis vomiting. diagnosis stroke confirmed by computed tomography magnetic...
Venous thromboembolism (VTE) is a common complication of intracerebral hemorrhage (ICH) patients in intensive care unit (ICU), but anticoagulation therapy ICH with VTE remains controversial. We aim to explore the risk factors and prognosis VTE.Medical records were collected from Medical Information Mart for Intensive Care III (MIMIC-III version 1.4) database. The assessed by multivariable logistic regression analysis Kaplan-Meier survival analysis, respectively.A total 848 included our...
Protofibrils of alpha-synuclein mediate neuronal cell death and propagate Parkinson's disease (PD). In this study, we investigated the relationship between rs3822086 C>T polymorphism located in fourth intron (SNCA) gene susceptibility to PD a Chinese Han population.146 patients 144 sex- age-matched healthy individuals (control group) were selected for study. The SNCA was examined all 300 study subjects by polymerase chain reaction-restriction fragment length (PCR-RFLP) analysis.The genotype...