A5100386490- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Nutrition and Health in Aging
- Frailty in Older Adults
- MicroRNA in disease regulation
- Pediatric Hepatobiliary Diseases and Treatments
- Fatty Acid Research and Health
- Liver physiology and pathology
- Gut microbiota and health
- Folate and B Vitamins Research
- Traditional Chinese Medicine Studies
- Cancer Mechanisms and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Peripheral Artery Disease Management
- Medical Research and Treatments
- Dementia and Cognitive Impairment Research
- Pharmacological Effects of Natural Compounds
- Pancreatitis Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- Body Composition Measurement Techniques
- Systemic Lupus Erythematosus Research
- Cancer-related gene regulation
Nanjing Medical University
2020-2025
Jiangsu Province Hospital
2023-2025
Changzhou No.2 People's Hospital
2020-2025
Guangdong Ocean University
2025
Southern Medical University
2025
Dongguan People’s Hospital
2025
Sun Yat-sen University
2025
Sun Yat-sen University Cancer Center
2025
Adaptive Biotechnologies (United States)
2020-2025
Shanghai Sixth People's Hospital
2017-2024
Non-coding RNAs (ncRNAs) have been shown to regulate gene expression involved in tumor progression of multiple malignancies. Our previous studies indicated that large suppressor kinase 1 (LATS1), a core part Hippo signaling pathway, functions as gastric cancer (GC). But, the underlying molecular mechanisms by which ncRNAs modulate LATS1 GC remain undetermined. The correlation and has-miR-424-5p (miR-424) with clinicopathological characteristics prognosis patients was analyzed TCGA...
Long non-coding RNAs (lncRNAs) contribute to colorectal cancer (CRC). However, the role of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In this study, we identify a lncRNA, GLCC1, which is significantly upregulated under starvation cells, supporting cell survival and proliferation by enhancing glycolysis. Mechanistically, GLCC1 stabilizes c-Myc transcriptional factor from ubiquitination direct interaction with HSP90 chaperon further specifies modification...
Early weaned piglets are vulnerable to diarrhea because of weaning stress and immaturity intestinal tract. Compelling evidence suggests that gut microbiota is vital host health. However, it not well understood on the composition succession piglet during transition. In our two trials, total 17 commercial were studied in a pig farm Jiangxi Province, China. Fresh feces collected for four times (10 days before weaned, day, 10 after 21 weaned) by rectal massage. Fecal bacterial was assessed 16S...
Objective The significance of the liver-microbiome axis has been increasingly recognised as a major modulator autoimmunity. aim this study was to take advantage large well-defined corticosteroids treatment-naïve group patients with autoimmune hepatitis (AIH) rigorously characterise gut dysbiosis compared healthy controls. Design We performed cross-sectional individuals AIH (n=91) and matched controls (n=98) by 16S rRNA gene sequencing. An independent cohort 28 34 analysed validate results....
T cells are involved in the early identification and clearance of viral infections also support development antibodies by B cells. This central role for makes them a desirable target assessing immune response to SARS-CoV-2 infection. Here, we combined two high-throughput profiling methods create quantitative picture T-cell SARS-CoV-2. First, at individual level, deeply characterized 3 acutely infected 58 recovered COVID-19 subjects experimentally mapping their CD8 through antigen stimulation...
Patients with gastric cancer commonly have a poor prognosis, owing to its invasiveness and distant metastasis. Recent studies confirmed the pivotal role of long non-coding RNAs (lncRNAs) in tumorigenesis progression malignant tumors, including cancer. However, little is known about molecular mechanism by which lncRNA AK023391 contributes A microarray was used identify differentially expressed adjacent normal tissues. In addition, RNA fluorescence situ hybridization (FISH) investigate...
Abstract Background N6-methyladenosine (m 6 A) RNA methylation and circular RNAs (circRNAs) have been shown to act vital roles in multiple malignancies including gastric cancer (GC). However, there is little knowledge about how m A modification of circRNAs contributes GC progression. Methods The association METTL14 expression with the clinicopathological characteristics prognosis patients was assessed by Western blot, Immunohistochemistry public datasets. In vitro vivo function experiments...
T helper cells that produce IL-17 (Th17 cells) have recently been identified as the third distinct subset of effector cells. Emerging data suggests Th17 play an important role in pathogenesis many liver diseases by regulating innate immunity, adaptive and autoimmunity. In this study, we examine mechanism autoimmune hepatitis (AIH). The serum levels IL-23, well frequency IL-17+ liver, were significantly elevated patients with AIH, compared to other chronic healthy controls. hepatic...
Non-coding RNAs (ncRNAs) have been reported to participate in tumor progression by regulating gene expression. Previous studies showed that protein phosphatase Mg2+/Mn2+ dependent 1F (PPM1F) acts a dual role cancer growth and metastasis. But, the underlying mechanisms which ncRNAs regulate PPM1F expression hepatocellular carcinoma (HCC) are poorly understood. The association between or miR-490-3p clinicopathological features prognosis patients with HCC was analyzed TCGA RNA-sequencing data....
Soft tissue injuries involving volumetric muscle loss (VML) are defined as the traumatic or surgical of skeletal with resultant functional impairment and represent a challenging clinical problem for both military civilian medicine. In response, variety engineering regenerative medicine treatments under preclinical development. A wide animal models being used, all critical limitations. The objective this study was to develop model VML that reproducible technically uncomplicated provide...
Accumulating evidence shows that, the dysregulation of circular RNAs (circRNAs) is associated with progression multiple malignancies. But, underlying mechanisms by which has_circ_0032627 (circDLST) contributed to gastric cancer (GC) remain undocumented. The expression and cellular localization circDLST its association clinicopathological characteristics prognosis in patients GC was analysed using fluorescence situ hybridization. Gain- loss-of-function experiments as well a subcutaneous...
Objectives N 6 -methyladenosine (m A) RNA methylation is implicated in the progression of multiple cancers via influencing mRNA modification. YTHDF1 can act as an oncogene gastric cancer (GC), while biological mechanisms which regulates tumorigenesis through m A modification remain largely unknown. Methods GEO and TCGA cohorts were analyzed for differentially expressed components GC clinical specimens their association with prognosis. Transwell flow cytometry assays well subcutaneous...
Chemoresistance is a major therapeutic challenge in advanced gastric cancer (GC). N6-methyladenosine (m6A) RNA modification has been shown to play fundamental roles progression. However, the underlying mechanisms by which m6A of circRNAs contributes GC and chemoresistance remain unknown. We found that hsa_circ_0030632 (circUGGT2) was predominant target METTL14, METTL14 knockdown (KD) reduced circUGGT2 levels but increased its mRNA levels. The expression markedly cisplatin (DDP)-resistant...
Transient elastography (TE) can reliably stage liver fibrosis via stiffness measurement (LSM) in chronic disease. However, the accuracy of TE for assessment patients with autoimmune hepatitis (AIH) is still limited. We evaluate staging AIH and compare other noninvasive diagnostic tools.A total 100 biopsy-proven were included. The correlation between LSM was analyzed using Spearman test. optimal cut-off values calculated predicting individual stages receiver-operating characteristic curve....
The most highly directed and specific autoantibody in human immunopathology is the serologic hallmark of primary biliary cholangitis (PBC), antimitochondrial antibodies (AMAs). However clinical significance finding a positive AMA, with normal alkaline phosphatase (ALP) remains enigmatic.We took advantage 169 consecutive outpatients who were identified as having but ALP levels between January 2012 2018. A liver biopsy was performed on 67/169 these AMA patients.In all patients we reconfirmed...
This study aimed to examine the relationship between physical performance and mild cognitive impairment (MCI) in Chinese older adults.The sample comprised 956 relatively healthy aged ≥65 years old community-dwelling participants (mean age, 72.56 ± 5.43 years; 56.8% female), which did not include those with dementia, severe impairment, mental illness etc. The Mini-Mental State Examination (MMSE) Instrumental Activities of Daily Living (IADL) scale were used for initial classification patients...
Targeting of the programmed cell-death 1 ligand (PD-L1) signal pathway is a promising treatment strategy in several cancers. The purpose this study was to evaluate clinical significance PD-L1 patients with colon adenocarcinoma (COAD). A total 240 who were diagnosed COAD from Cancer Genome Atlas (TCGA) RNA-sequencing data and another cohort for pair-matched samples (n = 40) tissue microarray (TMA) enrolled study. correlation or miR-191-5p expression clinicopathological features prognosis...
Calorie restriction (CR) and intermittent fasting (IF) can promote metabolic health through a process that is partially mediated by gut microbiota modulation. To compare the effects of CR IF with different dietary structures on microbiota, we performed an experiment in which mice were subjected to or regimen additional control (IFCtrl) group whose total energy intake was not from included. Each included for normal chow high-fat diet.We showed normal-chow mice, IFCtrl had similar positive...