A5054920033- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Galaxies: Formation, Evolution, Phenomena
- Circular RNAs in diseases
- Astronomy and Astrophysical Research
- Shoulder and Clavicle Injuries
- Shoulder Injury and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Astrophysical Phenomena and Observations
- Environmental remediation with nanomaterials
- Trauma Management and Diagnosis
- Gastroesophageal reflux and treatments
- Astrophysics and Cosmic Phenomena
- Antimicrobial Peptides and Activities
- Polyamine Metabolism and Applications
- Helicobacter pylori-related gastroenterology studies
- Cancer Mechanisms and Therapy
- Nanomaterials for catalytic reactions
- Bone health and treatments
- Blood transfusion and management
- Sperm and Testicular Function
- Lung Cancer Research Studies
- Radio Astronomy Observations and Technology
- Inflammation biomarkers and pathways
- Gut microbiota and health
Shanghai Sixth People's Hospital
2022-2024
Shanghai Jiao Tong University
2022-2024
Anhui Medical University
2024
Second Military Medical University
2022-2023
Peking University
2010-2017
Peking University People's Hospital
2016-2017
Third Hospital of Hebei Medical University
2016
Hebei Medical University
2013-2016
Sichuan University
2014-2015
Shanghai Astronomical Observatory
2009
Abstract Background N6-methyladenosine (m 6 A) RNA methylation and circular RNAs (circRNAs) have been shown to act vital roles in multiple malignancies including gastric cancer (GC). However, there is little knowledge about how m A modification of circRNAs contributes GC progression. Methods The association METTL14 expression with the clinicopathological characteristics prognosis patients was assessed by Western blot, Immunohistochemistry public datasets. In vitro vivo function experiments...
Chemoresistance is a major therapeutic challenge in advanced gastric cancer (GC). N6-methyladenosine (m6A) RNA modification has been shown to play fundamental roles progression. However, the underlying mechanisms by which m6A of circRNAs contributes GC and chemoresistance remain unknown. We found that hsa_circ_0030632 (circUGGT2) was predominant target METTL14, METTL14 knockdown (KD) reduced circUGGT2 levels but increased its mRNA levels. The expression markedly cisplatin (DDP)-resistant...
Diabetic nephropathy (DN) is one of the most frequent complications associated with type I and II diabetes mellitus. Kidneys from patients DN are characterized by mesangial matrix expansion increased thickness glomerular basement membrane, which induced reactive oxygen species (ROS) production. Previous studies have been conducted to investigate this; however, detailed mechanism progression remains be elucidated. The present study evaluated expression antisense mitochondrial non-coding RNA-2...
The effect of the preparation conditions on physicochemical characteristics, operating life, and reactivity Fe/Cu bimetallic particles was studied significantly by using a model pollutant (p-nitrophenol), scanning electron microscopy–energy dispersive spectrometry, X-ray diffraction spectrometry. results suggest that higher longer life were obtained under optimal conditions. Furthermore, conditions, Cu not easily dropped from Fe0 particle, weight ratio surface increased significantly....
We report the discovery of eight new quasars in one extragalactic field (five degree centered at RA=$08^h58^m08.2^s$, Dec=$01^o32'29.7''$) with LAMOST commissioning observations on December 18, 2009. These quasars, $i$ magnitudes from 16.44 to 19.34 and redshifts 0.898 2.773, were not identified SDSS spectroscopic survey, though six them less than 2.5 selected as quasar targets SDSS. Except source without near-IR $Y$-band data, seven these meet a newly proposed selection criterion involving...
The redshift range from 2.2 to 3 is known as the 'redshift desert' of quasars because with redshifts in this have similar optical colors normal stars and are thus difficult find sky surveys. A quasar candidate, SDSS J085543.40–001517.7, which was selected by a recently proposed criterion involving near-IR Y – K g z colors, identified spectroscopically new 2.427 Guoshoujing Telescope (LAMOST) commissioning observation 2009 December confirmed made NAOC/Xinglong 2.16 m telescope 2010 March....
We have collected all available spectra and photometric data from the SDSS catalog for bright AGNs complied first three months of Fermi large area telescope all-sky survey. Based on 106 high-confidence 11 low-confidence associated AGN list, photometry are DR7 28 sources (12 BL Lacs 16 FSRQs), two which AGNs. Among these sources, 20 (6 14 FSRQs). The black hole masses MBH broad line region (BLR) luminosity were obtained FSRQs by measuring line-widths strengths emission lines spectra....
Due to limited investigations about efficacy of tyrosine kinase inhibitors (TKIs) plus immune-checkpoint (ICIs) versus TKIs alone, and effects durations bone modifying agents (BMAs) on the survival patients with hepatocellular carcinoma (HCC) metastases (BoM), we aim compare both alone in combination ICIs, as well comparing long-term no or perioperative use BMAs for HCC BoM. Patients pathologically confirmed BoM were included study. They stratified into group + ICIs group, group. Overall...
BACKGROUND Traditional esophagogastroduodenoscopy (EGD), an invasive examination method, can cause discomfort and pain in patients. In contrast, magnetically controlled capsule endoscopy (MCE), a noninvasive is being applied for the detection of stomach small intestinal diseases, but its application treating esophageal diseases not widespread. AIM To evaluate safety efficacy detachable string MCE (ds-MCE) diagnosis diseases. METHODS Fifty patients who had been diagnosed with were...
Oxymatrine (OMT) as a quinazine alkaloid extracted from matrine has been shown to exhibit anti-inflammatory and anti-tumour effects. However, the protective mechanism of OMT on NSAID-associated small bowel mucosal injury remains unreported. We found that could improve clinical symptoms pathological inflammation scoring, reduce secretion proinflammatory cytokines IL-1β, IL-6 TNF-α cell apoptosis, promote proliferation protect intestinal barrier compared with Diclofenac Sodium (DS) group....
<title>Abstract</title> Background Accumulating evidence unveils that N6-methyladenosine (m<sup>6</sup>A) methylation modifications and deregulated circular RNAs (circRNAs) play critical roles in diverse malignancies including gastric cancer (GC). However, the underlying mechanisms by which ALKBH5 mediates m<sup>6</sup>A modification of circRNAs GC progression chemoresistance remain unknown. Methods The m<sup>6</sup>A-circRNA epi-transcriptomic microarray was applied to screen...
We employ a sample of 362 flat-spectrum radio quasars (FSRQs) to calculate their integrated luminosities by integrating the spectral energy distribution (SED) constructed with multi-band (radio, IR, optical, UV and X-ray) data. compare these those estimated from monochromatic multiplying them conventional bolometric correction factors. Our analysis shows that calculated SED are much larger than luminosities. Their departing behavior tightly correlates The relations between explored, which...
In this study, the effect of operating temperature on removal high p-nitrophenol (PNP) concentrations by Fe/Cu/H2O systems has been investigated thoroughly. The results suggest that only a higher (>40°C) could significantly improve efficiency PNP (e.g. 10 000 mg/L) systems. Meanwhile, lower concentration 500 be completely removed at 40°C. Furthermore, interaction between (10–85°C) and other key parameters including theoretical Cu mass loading (0–0.89 g Cu/g Fe), Fe/Cu dosage (5–35 g),...
The tumor microenvironment (TME) acts as a crucial role in the occurrence and development of osteosarcoma (OS). Despite this, mechanism controlling components immunity stroma remains mystery. To conduct this study, we download collate transcriptome data from TARGET database, whose full name is Therapeutically Applicable Research to Generate Effective Treatments, well available clinical information OS. CIBERSORT ESTIMATE methodology are used acquire proportions tumor-infiltrating immune cells...
Abstract Background: N6-methyladenosine (m 6 A) RNA modification has been shown to act fundamental roles in cancer progression. However, the underlying mechanisms by which m A of circRNAs contributes gastric (GC) remain unknown. Methods: METTL14-mediated was identified an A-circRNA epi-transcriptomic microarray and verified methylated immunoprecipitation (MeRIP) dot blot. Cell bio-behaviors were measured molecular oncology experiments vitro vivo . The tumorigenesis conducted RIP, luciferase...
Abstract Background: N6-methyladenosine (m 6 A) RNA methylation and its associated demethylase ALKBH5 participate in pathogenesis progression of multiple malignancies. The present study aimed to reveal the biological function clinical significance gastric cancer (GC). Method: prognostic expression was assessed by using tissue microarray, immunohistochemical analyses TCGA dataset human GC. functional role GC tumorigenesis were explored vitro vivo . Methylated immunoprecipitation sequencing...