A5102019754- Neuroblastoma Research and Treatments
- Renal and related cancers
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Virus-based gene therapy research
- Ethics and Legal Issues in Pediatric Healthcare
- Congenital Anomalies and Fetal Surgery
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Genetic Syndromes and Imprinting
- Cancer therapeutics and mechanisms
- Genetic factors in colorectal cancer
- Hematopoietic Stem Cell Transplantation
- Cancer-related molecular mechanisms research
- Chronic Lymphocytic Leukemia Research
- Neonatal Health and Biochemistry
- Platelet Disorders and Treatments
- Childhood Cancer Survivors' Quality of Life
- Carcinogens and Genotoxicity Assessment
- Urological Disorders and Treatments
- Hybrid Renewable Energy Systems
- Blood groups and transfusion
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2017-2025
Wenzhou Medical University
2017-2025
Shanghai Sixth People's Hospital
2024
Xiamen University
2024
Shanghai Jiao Tong University
2024
Guangzhou Women and Children Medical Center
2020
First Affiliated Hospital of Zhengzhou University
2020
The First Affiliated Hospital, Sun Yat-sen University
2020
Sun Yat-sen University
2020
Guangzhou Medical University
2020
AlkB homolog 5 (ALKBH5) has been proven to be closely related tumors. However, the role and molecular mechanism of ALKBH5 in neuroblastomas have rarely reported.The potential functional single-nucleotide polymorphisms (SNPs) were identified by National Center for Biotechnology Information (NCBI) dbSNP screening SNPinfo software. TaqMan probes used genotyping. A multiple logistic regression model was evaluate effects different SNP loci on risk neuroblastoma. The expression neuroblastoma...
Neuroblastoma is the primary cause of cancer death in childhood. METTL14 tightly linked to cancer. However, whether single-nucleotide polymorphisms (SNPs) gene could predispose neuroblastoma susceptibility lacks evidence. With an epidemiology case-control study, associations between SNPs and overall risk for were estimated 898 cases 1,734 controls. Following that, stratified analysis was performed. Among five analyzed SNPs, rs298982 G>A rs62328061 A>G exhibited a significant association with...
Certain sub-groups, including men and obese individuals, are more susceptible to ozone (O3) exposure, but the underlying molecular mechanisms remain unclear. In this study, male mice were divided into two dietary groups: one fed a high-fat diet (HFD), mimicking obesity conditions, other normal (ND), then exposed 0.5 ppm 2 O3 for 4 hours per day over days. The HFD exhibited significantly higher body weight serum lipid biochemical indicators compared ND mice. Obese also severe pulmonary...
Wilms tumor, a prevalent pediatric kidney cancer, has been extensively studied to elucidate its genetic mechanisms. NAT10 (N-acetyltransferase 10) is gene encoding acetyltransferase, which involved in various cellular processes, including RNA modification, DNA repair, and protein acetylation. The oncogenic role of cancer garnered significant attention. However, research on variants their associations with nascent. This study investigated the link between tumor risk via case‒control design...
OBJECTIVE Modification of 5-methylcytosine (m 5 C) exerts regulatory effects on RNA functionality, governing critical processes that include cell migration, survival, and differentiation. NSUN4 , a demethylase responsible for generating the m C modification, plays pivotal role in carcinogenesis cellular To date, there have been no documented reports gene polymorphisms neuroblastoma. METHODS The authors investigated 402 neuroblastoma patients 473 control subjects identified 4 potential...
Wilms tumor is a type of pediatric solid that arises partly due to somatic and germline mutations. Single-nucleotide polymorphisms (SNPs) in the RAS gene reportedly modify risk for several types human malignancies. We conducted multicenter study investigate whether variants predispose individuals tumor. Four SNPs were genotyped 355 cases 1070 controls. The included rs12587 G>T, rs7973450 A>G rs7312175 G>A KRAS, rs2273267 A>T NRAS. Individuals harboring GT genotype more likely develop than...
Abstract Background Wilms tumor is a frequently diagnosed renal cancer among children with unclear genetic causes. N6‐methyladenosine (m 6 A) modification genes play critical roles in tumorigenesis. However, whether variations of m A predispose to remain unclear. ALKBH5 (AlkB homolog 5) , crucial member genes, encodes demethylase that functions reverse RNA methylation. Methods Herein, we evaluated the association single nucleotide polymorphisms (SNPs) gene and susceptibility large...
Neuroblastoma ranks as the most commonly seen and deadly solid tumour in infancy. The aberrant activity of m
Abstract Background Wilms tumor is a common pediatric worldwide. Methyltransferase like 3 ( METTL3 ) core gene of the N 6 ‐methyladenosine (m A) modification that widely affects transcription tumor‐related genes in eukaryotes. has been extensively investigated various tumors but not tumor. Methods We describe five‐center case–control study with 414 patients and 1199 controls aiming to explore associations between polymorphisms (rs1061026 T>G, rs1061027 C>A, rs1139130 A>G rs1263801...
The genetic etiology of sporadic neuroblastoma remains largely obscure. RAN and RANBP2 genes encode Ras-related nuclear protein Ran-binding 2, respectively. These two proteins form Ran-RanBP2 complex that regulate various cellular activities including transport. Aberrant functions the are implicated in carcinogenesis. Given unknown role RAN/RANBP2 single nucleotide polymorphisms (SNPs) risk, we performed a multi-center case-control study Chinese children to assess association SNPs with risk....
Neuroblastoma is a lethal tumor that commonly occurs in children.Polymorphisms XPD reportedly influence risk for several types of cancer, though their roles neuroblastoma remain unclear.Here we endeavored to determine the relevance gene polymorphisms and susceptibility Chinese children genotyping three (rs3810366, rs13181 rs238406) 505 cases 1070 controls assessing contributions risk.Overall, detected no significant association between any single genotype risk.When genotypes were combined,...
Abstract Neuroblastoma ranks the most common seen solid tumour in childhood. Overexpression of LIN28A gene has been linked to development multiple human malignancies, but relationship between single nucleotide polymorphisms (SNPs) and neuroblastoma susceptibility is still under debate. Herein, we evaluated correlation four potentially functional SNPs (rs3811464 G>A, rs3811463 T>C, rs34787247 rs11247957 G>A) 505 patients 1070 controls from independent hospitals China. The strengths...
Wilms tumor is a highly heritable malignancy. Aberrant METTL14, critical component of N6-methyladenosine (m6A) methyltransferase, involved in carcinogenesis. The association between genetic variants the METTL14 gene and susceptibility remains to be fully elucidated. We aimed assess whether within this are implicated susceptibility.A total 403 patients 1198 controls were analyzed. genotypes assessed by TaqMan genotyping assay.Among five SNPs analyzed, rs1064034 T > A rs298982 G exhibited...
Wilms tumor is the most common embryonal renal malignancy in children.WDR4 an indispensable noncatalytic subunit of RNA N7-methylguanosine (m7G) methyltransferase complex and plays essential role tumorigenesis.However, relationship between polymorphisms WDR4 gene susceptibility to remains be fully investigated.We performed a large case-control study involving 414 patients 1199 cancer-free controls investigate whether single nucleotide (SNPs) are associated with susceptibility.WDR4 (rs2156315...
Neuroblastoma is the most common seen solid tumor in children less than one year old.Given that polymorphisms lncRNA H19 gene are observed several types of human malignancies, there likely to be similar events contribute pathogenesis neuroblastoma.We hypothesize single nucleotide (SNPs) might predispose neuroblastoma.Here, we genotyped three SNPs (rs2839698 G>A, rs3024270 C>G, rs217727 G>A) from a Chinese population (700 subjects with neuroblastoma and 1516 control subjects) enrolled six...
Neuroblastoma is one of the most common life-threatening extracranial tumors that mainly occurs in children, and its genetic etiology remains largely obscure.RNA m6A modification has been thought to play a key role cancer progression.YTHDF1 critical downstream gene by which RNA exerts functions.Single nucleotide polymorphisms YTHDF1 may affect expression biological activity, thereby leading abnormalities regulation m6A-modified eventually promoting initiation development tumors.Here, we...
To the Editor: Wilms tumor, or nephroblastoma, is most frequently diagnosed pediatric kidney cancer, accounting for >90% of all renal tumors in children 1–7 years old, and disease may be related to genetic factors.[1] As an emerging research spot, epitranscriptome has been implicated different RNA modifications human diseases, including cancers.[2] Methyltransferase-like 1 (METTL1), a critical N7-methylguanosine (m7G) methyltransferase, can catalyze formation m7G modification (mostly at...
Introduction: Neuroblastoma is an embryonal tumor of the sympathetic nervous system. The MYCN oncogene amplified in some neuroblastoma patients and correlated with poor prognosis. However, less known regarding relationship between gene single-nucleotide polymorphisms (SNPs) risk. Patients methods: To investigate contribution to risk, we performed a 3-center case–control study by genotyping 4 SNPs from 429 cases 884 controls. Results: results showed that only rs57961569 G>A was associated...
Neuroblastoma is the most frequently diagnosed neural tumor of childhood.Abnormal function long intergenic non-coding RNA (lincRNA) LINC00673 has been implicated in various human malignancies.Genomewide association studies revealed rs11655237 C>T polymorphism to be associated with risk neuroblastoma, though effect was not well defined, part due small sample size our earlier study.Herein, we verified impact on neuroblastoma 700 cases and 1516 controls from six centers China.After pooling all...
Abstract Wilms tumour is a renal malignancy that commonly occurs in children. LIN28A gene overexpression has been reported to be involved various human malignancies, while its roles risk are still under investigation. Here, we genotyped four polymorphisms 355 patients and 1070 healthy controls from hospitals China. The single nucleotide (SNPs) include the following: rs3811464 G>A, rs3811463 T>C, rs34787247 G>A rs11247957 G>A. Overall, found T>C were associated with increased...
Previous studies have revealed that WTAP is related to multiple types of cancer. Recently, has been reported as an independent prognostic factor in patients with neuroblastoma.To explore the association between three polymorphisms (rs9457712 G>A, rs1853259 A>G and rs7766006 G>T) neuroblastoma susceptibility Chinese populations, we performed this case-control study including 898 cases 1,734 controls. We genotyped these potentially functional single nucleotide (SNPs) by TaqMan assays. The odds...
Wilms tumor is the most frequently occurring renal malignancy in pediatrics. The FTO gene exhibits a featured genetic contribution to cancer development. Nonetheless, its single nucleotide polymorphism (SNP) remains unknown.In present study, 402 patients and 1198 healthy controls were successfully genotyped for SNPs (rs1477196 G>A, rs9939609 T>A, rs7206790 C>G rs8047395 A>G) using TaqMan SNP genotyping assays. Odds ratios (ORs) 95% confidence intervals (CIs), generated from unconditional...
Neuroblastoma (NB) is the most common extracranial tumor in children. YTHDC1, a member of RNA methylation modification binding proteins, plays critical roles occurrence and metastasis. However, it unclear whether YTHDC1 gene polymorphisms are related to NB susceptibility. Herein, we aimed evaluate association between (rs2293596 T>C, rs2293595 rs3813832 T>C) susceptibility by logistic regression models. In this eight-center case-control study, 898 patients with 1734 healthy controls were...