A5100757686- Pain Mechanisms and Treatments
- Insect and Pesticide Research
- Viral Infectious Diseases and Gene Expression in Insects
- Heat shock proteins research
- Ion channel regulation and function
- Neuroblastoma Research and Treatments
- Anesthesia and Pain Management
- Neuropeptides and Animal Physiology
- Pediatric Pain Management Techniques
- Pain Management and Opioid Use
- Anesthesia and Sedative Agents
- Cardiac electrophysiology and arrhythmias
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Receptor Mechanisms and Signaling
- Musculoskeletal pain and rehabilitation
- Botulinum Toxin and Related Neurological Disorders
- Pain Management and Placebo Effect
- Autism Spectrum Disorder Research
- Hereditary Neurological Disorders
- COVID-19 Clinical Research Studies
- Herpesvirus Infections and Treatments
- Plant Gene Expression Analysis
- Congenital gastrointestinal and neural anomalies
- Cancer-related molecular mechanisms research
Henan Provincial People's Hospital
2023-2024
Zhengzhou University
2019-2024
Henan University
2023-2024
Tongji Hospital
2011-2024
Huazhong University of Science and Technology
2013-2024
Chongqing Academy of Agricultural Sciences
2024
Zhengzhou Children's Hospital
2014-2023
Central Committee of the Communist Party of China
2023
Zhengzhou People's Hospital
2023
Chongqing University
2021-2022
Background: Nav1.8 sodium channels, encoded by SCN10A, are preferentially expressed in nociceptive neurons and play an important role human pain. Although rare gain-of-function variants SCN10A have been identified individuals with painful peripheral neuropathies, whether more common can effect at the channel level dorsal root ganglion, neuronal leading to a pain disorder or altered normal threshold has not determined. Results: Candidate single nucleotide polymorphism association approach...
Abstract Background Common types of musculoskeletal conditions include pain in the neck and shoulder areas. This study seeks to identify genetic variants associated with or based on a genome-wide association approach using 203 309 subjects from UK Biobank cohort look for replication evidence Generation Scotland: Scottish Family Health Study (GS:SFHS) TwinsUK. Methods A was performed adjusting age, sex, BMI nine population principal components. Significant independent were then sent GS:SFHS...
This study aimed to explore the role of a nonsynonymous single-nucleotide polymorphism, 3312G>T, in SCN9A, which was identified probands with congenital indifference pain, but is also present normal controls, prediction individual baseline pain perception, and postoperative sensitivity general population.Preoperative pressure thresholds tolerance were measured 200 patients undergoing pancreatectomy, analgesic demand recorded. These variables compared according SCN9A 3312G>T alleles. Logistic...
The sodium channels Nav1.7, Nav1.8 and Nav1.9 are critical for pain perception in peripheral nociceptors. Loss of function Nav1.7 leads to congenital insensitivity humans. Here we show that the spider peptide toxin called HpTx1, first identified as an inhibitor Kv4.2, restores nociception knockout (Nav1.7-KO) mice by enhancing excitability dorsal root ganglion neurons. HpTx1 inhibits activates but does not affect Nav1.8. This produces wild-type (WT) Nav1.7-KO mice, attenuates Nav1.9-KO has...
On the basis of our experience in application mechanical algometer and a number pilot experiments, we speculated that 0.1- 0.01-cm(2) probes might improve measurement pain sensitivity relative to conventional 1-cm(2) probe. Here, examined accuracy, feasibility, applicability these detecting sensitivity.Mechanical threshold tolerance tests were performed on subjects using three 1, 0.1, 0.01 cm(2) random order. We compared probes.The study was set at Tongji Medical College, Huazhong University...
Postoperative pain remains a complex problem that is difficult to manage in the clinical context, seriously affecting rehabilitation and quality of life patients after surgery. Nociceptors, which cell bodies are located dorsal root ganglion, crucial for initiating conducting signal. The peripheral voltage-gated sodium channels, including Nav1.7, mainly expressed key understanding mechanism underlying postoperative pain. particular, mutations encoding gene (SCN9A) can determine whether...
There are few studies on the impact of postoperative pain management (such as Acute Pain Service, APS) prognosis patients, especially research large samples, even less data Chinese patients. It is reported that only 25.12 % hospitals in China have established APS or similar teams, and than 10 them responsible for whole process analgesia services. Tongji Hospital affiliated to Medical College Huazhong University Science Technology has a professional team led by anesthesiologists (TJ-APS),...
encodes a core subunit of the SWI/SNF chromatin remodeling complex, which plays crucial role in regulation gene expression. Germline mutations
The physiological sensation of pain and rapid response to stimuli serve as an adaptive way avoid harmful situations. Our purpose was investigate why this protection disappears or almost for patients with congenital indifference (CIP).The study designed a case report by scanning the candidate genes within CIP patients.The set at Department Anesthesiology, Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan, China.We reported from two Chinese families that showed...
Critical patients with COVID-19 are thought to be at high risk of developing chronic pain. However, the exact nature and mechanisms COVID-19-related pain remain largely unknown. Here, we describe clinical features, treatments outcome herpes zoster as well postherpetic neuralgia in a 70-year-old woman critical COVID-19. The patient had history type 2 diabetes myasthenia gravis. She developed right 10 12 lumbar dermatomes recovery period Intravenous (250 mg 3 times day) then oral (400 5...
Glioblastoma (GBM) is a highly malignant tumor with poor prognosis, and new treatment strategies are urgently needed. Currently, the role of triggering receptor expressed on myeloid cells 1 (TREM-1) in tumors has been studied, but TREM-1 GBM remains unclear.Immunohistochemical staining for was performed 91 patients diagnosed GBM. Clinicopathological characteristics survival times were recorded. expression its effect prognosis analyzed using online Gene Expression Profiling Interactive...
The SARS-CoV-2 Omicron variant has become the dominant and exhibits immune escape to current COVID-19 vaccines, further boosting strategies are required.We have conducted a non-randomized, open-label parallel-controlled phase 4 trial evaluate magnitude longevity of responses booster vaccination with intramuscular adenovirus vectored vaccine (Ad5-nCoV), aerosolized Ad5-nCoV, recombinant protein subunit (ZF2001) or homologous inactivated (CoronaVac) in those who received two doses vaccines.The...
Background: The SCN9A gene product is a critical component in human pain perception. Recent studies found that single-nucleotide polymorphisms (SNPs) this contributed to the risk and severity of common phenotypes. Objectives: In study, we aimed assess use SNP screening for predicting postoperative pain. Study Design: A retrospective assessment patients who underwent gynecological laparoscopic surgery. Setting: Department anesthesiology, teaching hospital, medical college, major metropolitan...
Abstract Neuroblastoma ranks the most common seen solid tumour in childhood. Overexpression of LIN28A gene has been linked to development multiple human malignancies, but relationship between single nucleotide polymorphisms (SNPs) and neuroblastoma susceptibility is still under debate. Herein, we evaluated correlation four potentially functional SNPs (rs3811464 G>A, rs3811463 T>C, rs34787247 rs11247957 G>A) 505 patients 1070 controls from independent hospitals China. The strengths...
Background: Cumulative evidence suggests that neuronal death including autophagy, apoptosis, and necrosis is closely related to the occurrence development of cerebral ischemia–reperfusion (I/R) injury. Moreover, vagal nerve stimulation (VNS) involved in many different neuroprotective neuroplasticity pathways. Thus, VNS may be a novel approach for treating various neurodegenerative diseases. The present study aims determine whether protects against I/R injury rats by inhibiting autophagy...
Nav1.9, encoded by sodium voltage-gated channel alpha subunit 11 (SCN11A), is one of the main channels involved in pain transmission. Dysfunction Nav1.9 alters sensitivity, resulting insensitivity to or familial episodic pain. Our purpose was explore effects SCN11A single-nucleotide polymorphisms (SNPs) on postoperative sensitivity Chinese Han female patients after gynecological surgery. Here, we combined methods tag SNPs and candidate SNPs. The associations between eleven basic healthy...
Congenital insensitivity to pain (OMIM 243000) is an extremely rare disorder caused by loss-of-function mutations in SCN9A encoding Nav1.7. Although the and phenotypes of painlessness anosmia/hyposmia patients are previously well documented, complex relationship between genotype phenotype congenital remains unclear. Here, we report a patient with novel mutations. Functional significance was assessed HEK293 cells expressing Nav1.7, results showed that p.Arg99His significantly decreased...