A5101736678- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Viral Infections and Vectors
- Influenza Virus Research Studies
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Bacteriophages and microbial interactions
- Immune Response and Inflammation
- Respiratory viral infections research
- Medical and Biological Ozone Research
- Advanced Biosensing Techniques and Applications
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
West China Medical Center of Sichuan University
2019
Abstract The SARS-CoV-2 Omicron variant has become the dominant around world and exhibits immune escape to current COVID-19 vaccines some extent due its numerous spike mutations. Here, we evaluated responses booster vaccination with intramuscular adenovirus-vectored vaccine (Ad5-nCoV), aerosolized Ad5-nCoV, a recombinant protein subunit (ZF2001) or homologous inactivated (CoronaVac) in those who received two doses of 6 months prior. We found that Ad5-nCoV induced potent neutralizing activity...
T-cell immunity plays an important role in the control of SARS-CoV-2 and has a great cross-protective effect on variants. The Omicron BA.1 variant contains more than 30 mutations spike severely evades humoral immunity. To understand how affect cellular immunity, epitopes wild-type BALB/c (H-2d) C57BL/6 mice (H-2b) were mapped through IFNγ ELISpot intracellular cytokine staining assays. identified verified splenocytes from vaccinated with adenovirus type 5 vector encoding homologous spike,...
The SARS-CoV-2 Omicron variant has become the dominant and exhibits immune escape to current COVID-19 vaccines, further boosting strategies are required.We have conducted a non-randomized, open-label parallel-controlled phase 4 trial evaluate magnitude longevity of responses booster vaccination with intramuscular adenovirus vectored vaccine (Ad5-nCoV), aerosolized Ad5-nCoV, recombinant protein subunit (ZF2001) or homologous inactivated (CoronaVac) in those who received two doses vaccines.The...
The seasonality of individual influenza subtypes/lineages and the association epidemics with meteorological factors in tropics/subtropics have not been well understood. impact 2009 H1N1 pandemic on prevalence seasonal virus remains to be explored. Using wavelet analysis, periodicities A/H3N2, A/H1N1, A/H1N1pdm09, Victoria Yamagata were identified, respectively, Panzhihua during 2006-2015. As a subtropical city southwestern China, is first industrial upper reaches Yangtze River. relationship...