A5048361531- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Esophageal Cancer Research and Treatment
- Retinal Imaging and Analysis
- Medical Imaging Techniques and Applications
- Dark Matter and Cosmic Phenomena
- Retinal Diseases and Treatments
- Computational Physics and Python Applications
- Advanced optical system design
- Retinal and Optic Conditions
- Maternal Mental Health During Pregnancy and Postpartum
- Animal Virus Infections Studies
- Supramolecular Self-Assembly in Materials
- Physical Activity and Health
- Atomic and Subatomic Physics Research
- Ferroptosis and cancer prognosis
- Digital Imaging for Blood Diseases
- Obesity, Physical Activity, Diet
- Cancer Immunotherapy and Biomarkers
- Particle Detector Development and Performance
- COVID-19 Clinical Research Studies
- Single-cell and spatial transcriptomics
University of Chinese Academy of Sciences
2019-2025
Chinese Academy of Sciences
2019-2025
Wuhan University
2024-2025
State Key Laboratory of Applied Optics
2024-2025
Changchun Institute of Optics, Fine Mechanics and Physics
2024-2025
Zhengzhou University
2022-2024
University of Pittsburgh
2022-2024
Air Force Medical University
2023-2024
China Agricultural University
2022-2024
Central Committee of the Communist Party of China
2022-2024
Abstract Background The efficacy of neoadjuvant chemo-immunotherapy (NAT) in esophageal squamous cell carcinoma (ESCC) is challenged by the intricate interplay within tumor microenvironment (TME). Unveiling immune landscape ESCC context NAT could shed light on heterogeneity and optimize therapeutic strategies for patients. Methods We analyzed single cells from 22 baseline 24 post-NAT treatment samples stage II/III patients to explore association between pathological response anti-PD-1...
This paper presents an automated method for solving the initial structure of compact, high-zoom-ratio mid-wave infrared (MWIR) zoom lenses. Using differential analysis, focal length variation process lenses under paraxial conditions is investigated, and a model power distribution relative motion three movable lens groups established. The particle swarm optimization (PSO) algorithm introduced into zooming program developed in MATLAB to solve structure. integrates physical constraints from...
The deformation of the image plane due to gravity, clamping forces, and surface shape errors can significantly impact exposure accuracy imaging quality doubly telecentric projection optical system. To address issues resolution degradation resulting from non-conjugate planes, this paper proposes a high-precision method for compensating using dual-prism approach, establishes an analytical compensation model, theoretical derivation quantification effects devices on defocus, tilt, aberration are...
Human epidermal growth factor receptor 2 (HER2) is an anti-cancer drug target for colon cancer. Among patients with colorectal malignancy (colorectal cancer, CRC), those HER2 mutations have a poor overall prognosis and significantly increased resistance. In recent years, anti-HER2 therapeutic drugs developed rapidly. According to several clinical studies case reports, therapy, as emerging approach, plays crucial role in the treatment of HER2-positive CRC patients. Here, we present descending...
Abstract Background Depression is an important public health burden, its risk of occurrence associated with vitamin D deficiency and may also increase age, while serum levels are closely related to age. Objective The purpose this study was evaluate whether age depression after adjustment for each other. Materials methods We extracted data from NHANES 2013–2018, including demographic characteristics, level, physical activity, body measures. A total 15,156 adults aged 20 years or older (mean...
Abstract The SARS-CoV-2 Omicron variant has become the dominant around world and exhibits immune escape to current COVID-19 vaccines some extent due its numerous spike mutations. Here, we evaluated responses booster vaccination with intramuscular adenovirus-vectored vaccine (Ad5-nCoV), aerosolized Ad5-nCoV, a recombinant protein subunit (ZF2001) or homologous inactivated (CoronaVac) in those who received two doses of 6 months prior. We found that Ad5-nCoV induced potent neutralizing activity...
Abstract Background Smoking is harmful, which has become a major public health burden. Physical activity may be related to smoking. one of the current methods for smoking control and cessation. Different types physical have different effect on behavior. Objective The purpose this study was identify direction extent impact above moderate intensity (including work activity, recreational commuter sedentary behavior) Materials In study, total 2,015 individuals (1,233 males 782 females, mean age...
Abstract The aim of dynamic prediction is to provide individualized risk predictions over time, which are updated as new data become available. In pursuit constructing a model for progressive eye disorder, age-related macular degeneration (AMD), we propose time-dependent Cox survival neural network (tdCoxSNN) predict its progression using longitudinal fundus images. tdCoxSNN builds upon the by utilizing capture nonlinear effect covariates on outcome. Moreover, concurrently integrating...
Abstract Age-related macular degeneration (AMD) is the principal cause of blindness in developed countries, and its prevalence will increase to 288 million people 2040. Therefore, automated grading prediction methods can be highly beneficial for recognizing susceptible subjects late-AMD enabling clinicians start preventive actions them. Clinically, AMD severity quantified by Color Fundus Photographs (CFP) retina, many machine-learning-based are proposed severity. However, few models were...
The SARS-CoV-2 Omicron variant has become the dominant and exhibits immune escape to current COVID-19 vaccines, further boosting strategies are required.We have conducted a non-randomized, open-label parallel-controlled phase 4 trial evaluate magnitude longevity of responses booster vaccination with intramuscular adenovirus vectored vaccine (Ad5-nCoV), aerosolized Ad5-nCoV, recombinant protein subunit (ZF2001) or homologous inactivated (CoronaVac) in those who received two doses vaccines.The...
Large language models (LLMs) have demonstrated a powerful ability to answer various queries as general-purpose assistant. The continuous multi-modal large (MLLM) empower LLMs with the perceive visual signals. launch of GPT-4 (Generative Pre-trained Transformers) has generated significant interest in research communities. GPT-4V(ison) power both academia and industry fields, focal point new artificial intelligence generation. Though success was achieved by GPT-4V, exploring MLLMs...
Metal ions play a dual role in biological systems. Although they actively participate vital life processes, may contribute to protein aggregation and misfolding thus development of diseases other pathologies. In nanofabrication, metal mediate the formation nanostructures with diverse properties. Here, we investigated self-assembly α-lactalbumin into nanotubes induced by coordination ions, screened among series Mn
Abstract Novel neoadjuvant immunotherapy combined with chemotherapy (neoICT) has improved outcomes for patients esophageal squamous-cell carcinoma (ESCC), but challenges persist in low response rates and therapy resistance. Little is known about the intra-tumoral heterogeneity ESCC tumor microenvironment (TME) that underlies differential responses to therapy. We applied single-cell RNA sequencing (scRNA-seq) profiling multiplexed immunofluorescence staining thoroughly decipher TME specimens...
Abstract INTRODUCTION Oculomotor and gait dysfunctions are closely associated with cognition. However, oculo‐gait patterns their correlation cognition in cerebral small vessel disease (CSVD) remain unclear. METHODS Patients CSVD from a hospital‐based cohort ( n = 194) individuals presumed early community‐based 319) were included. Oculo‐gait measured using the artificial intelligence (AI) –assisted ‘EyeKnow’ eye‐tracking ‘ReadyGo’ motor evaluation systems. Multivariable linear logistic...
Proteins used as building blocks to template nanostructures with manifold morphologies have been widely reported. Understanding their self-assembly and reassembly mechanism is important for designing functional biomaterials. Herein, we show that enzyme-hydrolyzed α-lactalbumin (α-lac) can self-assemble into either nanotubes in the presence of Ca2+ ions or nanospheres absence solution. Remarkably, such assembled α-lac be elongated by adding preassembled solution, which suggests self-assembled...
Recently, partially coherent beams with twist phases have attracted growing interest due to their nontrivial dynamic characteristics. In this work, the propagation characteristics of a twisted cosine-Gaussian correlated radially polarized beam such as spectral intensity, degree coherence, polarization, state and change are investigated in detail. Due presence phase, spot, polarization experience rotation during transmission, but is not twisted. Meanwhile, although speeds closely depend on...
This work presents a novel stereo coded aperture gamma camera based on four detection modules placed within quadrants. Each module includes 48 × strips of Bi4Ge3O12 scintillators, 24 pieces silicon photomultipliers (SiPMs), and set data acquisition circuits. All signals from the SiPMs are individually extracted finally simplified into 144 outputs to calculate positions energies gamma-rays. Two masks modified uniformly redundant arrays fixed in front top-right bottom-left two anti-masks...
Esophageal squamous cell carcinoma (ESCC) accounts for the main esophageal cancer type, which is related to advanced stage and poor survivals. Therefore, novel diagnostic biomarkers are critically needed. In current research, we aimed screen based on machine learning. The expression profiles were obtained from GEO datasets (GSE20347, GSE38129, GSE75241) TCGA datasets. Differentially expressed genes (DEGs) screened between 47 ESCC nontumor samples. LASSO regression model SVM-RFE analysis...
康普顿成像是直观感知核辐射的探测技术之一, 但因受限于探测器体积和成像事例的类型, 能量范围通常为0.3~3 MeV, 难以在对天然核素γ成像的基础上同时兼顾能量分布在3~7 MeV的瞬发γ成像应用. 覆盖0.3~7 MeV范围的宽能域γ成像是扩展核辐射探测与成像应用领域的重要发展方向之一, 基于两次散射的三层探测器结构是一种极具潜力的实现方案, 其中探测器的设计与构建是该方案的基础与关键核心. 考虑系统成本和扩展灵活性等因素, 本文选用硅光电倍增管(SiPM)阵列和钆镓铝石榴石(GAGG:Ce)阵列作为探测器材料. 根据三层探测器的成像事例要求, 分析每层探测器内的作用事例类型特征; 并基于Geant4蒙特卡罗模拟平台构建包含材料光学参数的仿真模型, 通过设置物理过程与两种信息提取方式, 对比研究了不同几何参数情形下的探测器位置散点图和探测器内作用事例类型统计结果. 根据仿真设计, 制备了由像素数为15×15, 像素大小为3.2×3.2 mm<sup>2</sup>, 厚度分别为3 mm和10 mm的GAGG阵列和1.25 mm厚度光导组成的两种规格SiPM探测器模块,...
(1) Background: The imaging energy range of a typical Compton camera is limited due to the fact that scattered gamma photons are seldom fully absorbed when incident energies above 3 MeV. Further improving upper limit gamma-ray has important application significance in active interrogation special nuclear materials and chemical warfare agents, as well verification proton therapy; (2) Methods: To realize imag-ing wide 0.3~7 MeV, principle prototype, named portable three-layer camera, was...