A5051886637- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Bone Metabolism and Diseases
- Cell Adhesion Molecules Research
- Renal and related cancers
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- interferon and immune responses
- Sperm and Testicular Function
- Genetic Associations and Epidemiology
- Reproductive System and Pregnancy
- Stress Responses and Cortisol
- Cancer Mechanisms and Therapy
- Platelet Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone health and osteoporosis research
- Tryptophan and brain disorders
- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- MRI in cancer diagnosis
- Ovarian cancer diagnosis and treatment
- Congenital heart defects research
- Assisted Reproductive Technology and Twin Pregnancy
- Multiple Myeloma Research and Treatments
Gansu University of Traditional Chinese Medicine
2025
Shandong Provincial Hospital
2013-2024
Shandong University
2013-2024
Obstetrics and Gynecology Hospital of Fudan University
2024
Xuan Wu Hospital of the Capital Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Shandong First Medical University
2024
Yangon University of Economics
2023
Chinese University of Hong Kong
2022
Ministry of Education of the People's Republic of China
2013-2015
Abstract Background Diabetic cardiomyopathy (DCM) is a crucial complication of long-term chronic diabetes that can lead to myocardial hypertrophy, fibrosis, and heart failure. There increasing evidence DCM associated with pyroptosis, form inflammation-related programmed cell death. Growth differentiation factor 11 (GDF11) member the transforming growth β superfamily, which regulates oxidative stress, inflammation, survival mitigate infarction, vascular injury. However, role GDF11 in...
Our previous genome-wide association study identified LH/choriogonadotropin receptor (LHCGR) as a susceptibility gene for polycystic ovary syndrome (PCOS). The objective of this was to determine whether the genetic or epigenetic components associated with LHCGR participate in pathogenesis PCOS. exons and flanking regions were sequenced from 192 women PCOS, no novel somatic mutations identified. In addition, methylation statuses 6 cytosine-phosphate-guanine (CpG) sites promoter region...
Background Fat mass and obesity-associated gene (FTO) has been associated with obesity, especially the common variant rs9939609. Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disorder over 50% of patients are overweight/obese. Thus FTO potential candidate for PCOS but their relationship confusing remains to be clarified in different population large sample size. Method This study was performed adopting two-stage design by genotyping SNP The first set comprise 741 704...
Human epidermal growth factor receptor 2 (HER2) is an anti-cancer drug target for colon cancer. Among patients with colorectal malignancy (colorectal cancer, CRC), those HER2 mutations have a poor overall prognosis and significantly increased resistance. In recent years, anti-HER2 therapeutic drugs developed rapidly. According to several clinical studies case reports, therapy, as emerging approach, plays crucial role in the treatment of HER2-positive CRC patients. Here, we present descending...
17β-Estradiol (E2) is generally considered neuroprotective in humans. However, the current clinical use of estrogen replacement therapy (ERT) based on physiological dose E2 to treat menopausal syndrome and has limited therapeutic efficacy. The efficacy potential toxicity superphysiological doses ERT for neurodegeneration are unknown.In this study, we investigated effect with a supraphysiologic (0.5 mg/kg, sE2) treatment mouse models established by ovariectomy. We performed open field, Y-maze...
Follicle-stimulating hormone (FSH) and luteinizing (LH) play critical roles in female reproduction, while the underlying genetic basis is poorly understood. Genome-wide association studies (GWASs) of FSH LH levels were conducted 2590 Chinese females including 1882 polycystic ovary syndrome (PCOS) cases 708 controls. GWAS for level identified multiple variants at FSHR showing genome-wide significance with top variant (rs2300441) located intron FSHR. The A allele rs2300441 led to a reduced...
Polycystic ovary syndrome (PCOS) is a complex multifactor disorder and genetic factors have been implicated in its pathogenesis. Our previous genome-wide association study (GWAS) had identified allele frequencies several single nucleotide polymorphisms (SNPs) gene USP34 (Ubiquitin-Specific Protease 34) were significantly different between PCOS cases controls. This was aimed to replicate the results another independent cohort. One thousand two hundred eighteen 1057 controls recruited....
Abstract Menopause may be an important pathogenic factor for Alzheimer's disease (AD). The M1 polarization of microglia and neuroinflammatory responses occur in the early pathogenetic stages AD. Currently, no effective monitoring markers are available AD’s pathological manifestations. Radiomics is automated feature generation method extraction hundreds quantitative phenotypes (radiomics features) from radiology images. In this study, we retrospectively analyzed magnetic resonance T2-weighted...
This study investigated the impact of DNA methylation in 5′ untranslated region-CpG island (5′ UTR) HLA-G gene on soluble (sHLA-G) levels immune thrombocytopenia (ITP) patients, shedding light sHLA-G’s regulatory mechanisms ITP. Using a cohort 53 participants, including ITP profiles gene’s UTR were analyzed with Sequenom MassARRAY Methylation Analysis. sHLA-G measured by enzyme-linked immunosorbent assay, and platelet antibodies assessed using modified MAIPA. Results showed increased at...
Abstract Background Gout is associated with increased risks of cardiovascular events. However, it remains uncertain whether achieving the control targets for risk factors can attenuate this risk. This study evaluated association between attainment targeted seven and incidence major adverse events (MACCE) among patients gout. Methods From UK Biobank database, we analyzed data from participants diagnosed gout at baseline (2006-2010). These individuals were followed to monitor MACCE. stratified...
Objective: To investigate the clinicopathological, molecular pathological features, and family genetic pedigree of small cell carcinoma ovary, hypercalcemic type (SCCOHT). Methods: A total 16 cases SCCOHT diagnosed in Obstetrics Gynecology Hospital Fudan University from January 2013 to 2023 were collected. The clinicopathologic SMARCA4/2/B1 protein expression, outcomes SMARCA4 gene detection reported. follow-up study was also carried out. Results: average age at diagnosis 28.7 years (range...
As a crucial transcription factor for spermatogenesis, GATA-binding protein 4 (GATA4) plays important roles in the functioning of Sertoli and Leydig cells. Conditional knockout GATA4 mice results age-dependent testicular atrophy loss fertility. However, whether is associated with human azoospermia has not been reported. Herein, we analyzed gene by direct sequencing samples obtained from 184 Chinese men idiopathic nonobstructive (NOA). We identified missense mutation (c.191G>A, p.G64E), nine...
Sox8, encoding a SRY-related HMG box transcription factor, is essential in Sertoli cells for germ cell differentiation via regulation of integrity the blood–testis barrier (BTB) as well Sertoli-germ adhesion. Inactivation Sox8 gene mice causes postnatal progressive spermatogenic failure, resulting male infertility. This study aims to investigate whether variants SOX8 contribute pathogenesis idiopathic non-obstructive azoospermia (NOA) or oligozoospermia. A case–control genetic was conducted...
To study the expression of HIF-1alpha and SDF-1/CXCR4 in repopulating H22 tumor tissue mechanism angiogenesis polypeptide extract from scorpion venom (PESV) during chemotherapy treatment.The was monitored by immunohistochemistry, level determined Qwin V3 image analyzing software. The correlation between SDF-1 analyzed. content detected ELISA.HIF-1alpha found no difference model group 14 d 21 d, up-regulated 28 d. There change observed low-dose PESV group. In high-dose group, high low ELISA...
Abstract Background 17β-Estradiol (E2) is generally considered neuroprotective in humans. However, the current clinical use of estrogen replacement therapy (ERT) based on physiological dose E2 to treat menopausal syndrome and has limited therapeutic efficacy. The efficacy potential toxicity superphysiological doses ERT for neurodegeneration are unknown. Methods In this study, we investigated effect with a supraphysiologic (0.5 mg/kg, sE2) treatment mouse models established by ovariectomy. We...
Background and Purpose Recent evidence suggests that postmenopausal osteoporosis is associated with increased bone resorption function in osteoclasts, of which Cathepsin K a key molecule. In this study, we aimed to screen small molecule compounds targeting evaluate whether they affect osteoclast function. Experimental Approach We screened out the small-molecule compound NVP-BHG712 CTSK by molecular docking, studied its pharmacological effect on osteoclasts. To end, evaluated mass changes...