A5102021561- Ovarian function and disorders
- Reproductive Biology and Fertility
- Osteoarthritis Treatment and Mechanisms
- Clinical Laboratory Practices and Quality Control
- Folate and B Vitamins Research
- Knee injuries and reconstruction techniques
- Sleep and related disorders
- Pregnancy and Medication Impact
- Sperm and Testicular Function
- Meta-analysis and systematic reviews
- Hematological disorders and diagnostics
- Rheumatoid Arthritis Research and Therapies
- Schizophrenia research and treatment
- Growth Hormone and Insulin-like Growth Factors
- Traditional Chinese Medicine Studies
- Total Knee Arthroplasty Outcomes
- Gout, Hyperuricemia, Uric Acid
- Helicobacter pylori-related gastroenterology studies
- Nuclear Structure and Function
- Occupational Health and Performance
- Cerebrovascular and genetic disorders
- Congenital limb and hand anomalies
- Bone health and osteoporosis research
- Assisted Reproductive Technology and Twin Pregnancy
- Hypothalamic control of reproductive hormones
Zhengzhou University
2023-2024
Shandong University
2015-2023
Nantong University
2023
National Center for Clinical Laboratories
2016-2023
Ministry of Education of the People's Republic of China
2015-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2023
Hangzhou Medical College
2022
Zhejiang Provincial People's Hospital
2022
Peking Union Medical College Hospital
2016-2022
Luoyang Orthopedic-Traumatological Hospital of Henan Province
2018-2022
Premature ovarian insufficiency (POI) is highly heterogeneous, both in phenotype and etiology. They are not yet clearly stated correlated. To characterize clinical presentations of a large, well-phenotyped cohort women with POI, correlate phenotypes etiologies to draw comprehensive picture POI. In this retrospective study, total 955 Chinese overt POI between 2006 2015 were systemically evaluated analyzed. The phenotypic features, including menstrual characteristics, hormone profiles,...
This study investigated the risk factors and early predictors for heterotopic pregnancy (HP) after in vitro fertilization embryo transfer (IVF-ET). From January 2008 to 2013, 41 cases of HP 72 intrauterine twin IVF-ET were recruited retrospectively analyzed. Compared with group, group had a lower basal luteinizing hormone (LH) level (P = 0.005) more history hydrosalpinx 0.008). After 14 days IVF-ET, serum β-HCG (β-human chorionic gonadotropin), E2 (Estradiol) P (Progesterone) levels...
Background: Cognitive dysfunction has been recognized as a cardinal feature of schizophrenia. Elucidating the neurobiological substrates cognitive in schizophrenia would help identify underlying mechanism this disorder. The rs1064395 single nucleotide polymorphism, within gene encoding neurocan ( NCAN ), is reported to be associated with European populations and may influence brain structure patients Methods: In study, we aimed explore whether confers some risk for Han Chinese. We recruited...
Abstract Background Unhealthy lifestyles are risk factors for non-communicable diseases (NCDs) and tend to be clustered, with a trajectory that extends from adolescence adulthood. This study investigated the association of diets, tobacco, alcohol, physical activity (PA), screen time (ST) sleep duration (SD) in total six lifestyles, separately as cumulative lifestyle scores, sociodemographic characteristics among school-aged adolescents Chinese city Zhengzhou. Methods In aggregate, 3,637 aged...
Kisspeptin is a polypeptide that plays an important role in reproductive endocrine regulation. The aim of present study was to investigate the dynamic trend kisspeptin levels during menstrual cycle and elucidate relationship between ovulation. First, 15 female volunteers with regular cycles were recruited detect change serum urine over one within each individual. Subsequently, 114 samples 79 from individuals randomly collected at outpatient department better ascertain results. showed...
Dyslipidemia is common in polycystic ovary syndrome (PCOS). This study was aimed to investigate whether fatty acid desaturase genes (FADS), a dyslipidemia-related gene cluster, are associated with PCOS. We scanned variations of FADS using our previous data genome-wide association (GWAS) for PCOS and selected rs174570 further study. The case-control conducted an independent cohort 1918 cases 1889 age-matched controls family-based set 243 core family trios probands. Minor allele frequency...
Endoplasmic reticulum stress plays a crucial role in the pathogenesis of neuroinflammation and chronic pain. This study hypothesized that PRKR-like endoplasmic kinase (PERK) inositol-requiring enzyme type 1 (IRE1) regulate lipocalin-2 (LCN2) Nod-like receptor family pyrin domain containing 3 (NLRP3) expression astrocytes, thereby contributing to morphine tolerance hyperalgesia. The was performed Sprague-Dawley rats C57/Bl6 mice both sexes. LCN2 NLRP3 assessed by Western blotting. tail-flick,...
Abstract Background The effectiveness of smokeless moxa and other means to reduce exposure are extensively investigated with regards the health consequences inhalation smoke, clinical studies indicate that classical moxibustion is superior moxa. This study aims quantify effects particle density in smoke on outcome an established model, demonstrated be effective for moxibustion. Objectives purpose this explore ultrastructure knee cartilage expression cytokine, tissue necrosing factor–alpha...
Abstract Objective: To clarify nutrient supplementation usage and primary source of information among pregnant women in China. Design: This cross-sectional study used on collected via face-to-face interviews. Data the folic acid, Ca/vitamin D, Fe, vitamins, DHA other dietary supplements were collected. Primary was categorised as family/relatives, friends/co-workers, Internet, books/magazines, television/radio, doctors, people oneself. Setting: Maternal Child Health Hospital Chengdu,...
Background Alkaline phosphatase (ALP) is critical for various diseases. The International Federation of Clinical Chemistry and Laboratory Medicine had recommended the new reference procedure in 2011, but many manufacturers did not trace results to higher procedure. Since 2012, National Center Laboratories (NCCL) China has organized trueness verification program (TV) with commutable materials. present study summarizes 4-year TV give an overview measurement standardization ALP results. Methods...
Abstract Objectives Except for the large bias of some measurement systems serum cystatin C (CysC) measurements, unacceptable imprecision has been observed heterogenous system. This study analyzed external quality assessment (EQA) results in 2018–2021 to provide an insight into CysC assays. Methods Five EQA samples were sent participating laboratories every year. Participants divided reagent/calibrator-based peer groups, which robust mean each sample and coefficient variation (CV) calculated...
Obese women have fewer oocytes retrieved, an increased cancelation rate, a higher miscarriage and lower live birth rate after assisted reproductive technology (ART) treatment compared with normal weight. Weight loss before ART can significantly improve pregnancy rates and/or births. An orlistat plus diet intervention could promote weight loss, but there is no evidence from randomized clinical trials evaluating the effect of preconceptional on outcome in overweight obese women. We are...
Abstract Background Serum uric acid is a critical clinical indicator, and results without equivalence among laboratories cause troubles for disease diagnosis patient management. External quality assessment (EQA) common tool enhancing harmonization/standardization, therefore, the National Center Clinical Laboratories in China has initiated category 1 EQA serum measurement since 2010 evaluating its process of standardization. Methods Commutable samples with target values assigned by reference...
Intracranial atherosclerotic stenosis (ICAS) is one of the leading causes stroke worldwide. Current diagnostic evaluations and treatments remain insufficient to assess vulnerability intracranial plaques reduce recurrence in symptomatic ICAS. On other hand, asymptomatic ICAS associated with an increased risk cognitive impairment. The pathogenesis related decline largely unknown. aim SICO-ICAS study (stroke incidence outcomes ICAS) elucidate pathophysiology impairment population,...
Long intergenic non-protein coding RNA 1138 (LINC01138) plays a vital role in human cancers. In this study, we aimed to investigate the effect of LINC01138 on progression osteoarthritis (OA) and explore its potential mechanism action.