A5068954598- Ovarian function and disorders
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy and preeclampsia studies
- Reproductive Health and Contraception
- Endometriosis Research and Treatment
- Birth, Development, and Health
- Sperm and Testicular Function
- Gestational Diabetes Research and Management
- Lipid metabolism and disorders
- Liver physiology and pathology
- Genomic variations and chromosomal abnormalities
- Uterine Myomas and Treatments
- Aquaculture Nutrition and Growth
- Hormonal and reproductive studies
- Bone Metabolism and Diseases
- Gynecological conditions and treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Testicular diseases and treatments
- Parvovirus B19 Infection Studies
- COVID-19 and healthcare impacts
Shandong University
2016-2025
Jilin Agricultural University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2025
Ministry of Education of the People's Republic of China
2016-2024
Shandong Maternal and Child Health Hospital
2023
Yuhuangding Hospital
2022
Shandong Provincial Hospital
2016-2020
Guangxi Maternal and Child Health Hospital
2018
Shanghai Jiao Tong University
2018
Penn State Milton S. Hershey Medical Center
2018
The transfer of fresh embryos is generally preferred over the frozen for in vitro fertilization (IVF), but some evidence suggests that frozen-embryo may improve live-birth rate and lower rates ovarian hyperstimulation syndrome pregnancy complications women with polycystic ovary syndrome.In this multicenter trial, we randomly assigned 1508 infertile who were undergoing their first IVF cycle to undergo either fresh-embryo or embryo cryopreservation followed by transfer. After 3 days...
Embryo selection with preimplantation genetic testing for aneuploidy (PGT-A) may improve pregnancy outcomes after initial embryo transfer. However, it remains uncertain whether PGT-A improves the cumulative live-birth rate as compared conventional in vitro fertilization (IVF).
Implantation failure remains a critical barrier to in vitro fertilization. Prednisone, as an immune-regulatory agent, is widely used improve the probability of implantation and pregnancy, although evidence for efficacy inadequate.To determine 10 mg prednisone compared with placebo on live birth among women recurrent failure.A double-blind, placebo-controlled, randomized clinical trial conducted at 8 fertility centers China. Eligible who had history 2 or more unsuccessful embryo transfer...
Abstract Objective To test the hypothesis that a freeze-all strategy would increase chance of live birth compared with fresh embryo transfer in women low prognosis for vitro fertilisation (IVF) treatment. Design Pragmatic, multicentre, randomised controlled trial. Setting Nine academic fertility centres China. Participants 838 IVF treatment defined by ≤9 oocytes retrieved or poor ovarian reserve (antral follicle count <5 serum anti-Müllerian hormone level <8.6 pmol/L). Interventions...
Abstract Background The endometrial preparation during frozen embryo transfer (FET) can be performed by natural cycle (NC), hormone replacement therapy (HRT) and with ovulation induction (OI). Whether different FET protocols affect maternal neonatal outcomes is still inconclusive. Methods This was a retrospective cohort study that included 6886 women who delivered singleton live birth babies after 28 weeks of pregnancy underwent from January, 2015 to July, 2018. Women were divided into three...
Do oral contraceptives (OCs) and progestins impact live birth rate of IVF when used for cycle scheduling in women with polycystic ovary syndrome (PCOS)? OCs were associated lowered rates pregnancy after fresh embryo transfer, whereas this purpose yield higher than OCs. Due to oligo-menorrhea PCOS, progestin are extensively schedule the start an PCOS. Little is known about effect such pretreatments on outcomes, especially, birth. This was a nested cohort study secondary analysis multicenter...
Is the total dose of exogenous gonadotropins associated with blastocyst aneuploidy or live-birth rates in PGS cycles Chinese women? The is not significantly women. administration ovarian stimulation leads to supraphysiological steroid concentrations compared those seen during natural cycles. rate euploid blastocytes negatively female age. This a retrospective study using anonymised data on performed China from 2013 2017. Data 1088 and 3219 embryos were analysed by array-comparative genomic...
Abstract Context The high mobility group AT hook 2 (HMGA2) gene was previously identified in a genome-wide association study as candidate risk that might be related to polycystic ovary syndrome (PCOS). Whether HMGA2 contributes promoting granulosa cell (GC) proliferation PCOS remains unknown. Objective We sought determine whether is involved the ovarian dysfunction of and mechanism increased GC proliferation. Patients Cells mRNA expression analyzed GCs from 96 women with 58 healthy controls....
Both antimüllerian hormone and body mass index are associated with the pregnancy outcomes in women polycystic ovary syndrome undergoing vitro fertilization. This study aimed to explore effect of different combinations on was a post hoc secondary analysis multicenter randomized trial. A total 625 from 1 center levels measured before fertilization treatment were classified into 6 groups: group (normal weight low group), B intermediate C high D (overweight/obese E F group). After adjustment via...
(Abstracted from N Engl J Med 2018;378:126–136) A previous randomized controlled trial involving women with polycystic ovary syndrome (PCOS) compared fresh-embryo transfer elective freezing of all embryos followed by frozen-embryo transfer. The data showed that had a higher live-birth rate in these Whether also increases rates among ovulatory infertility without PCOS is uncertain.
What is the direct genetic contribution of polycystic ovary syndrome (PCOS) susceptibility single nucleotide polymorphisms (SNPs), identified by previous genome-wide association studies (GWAS) to definitive clinical features syndrome?Each PCOS feature had a specific association, and rs4385527 in chromosome 9 open reading frame 3 (C9orf3) conferred particular risk three defined this study, which suggested its fundamental role etiology PCOS.PCOS heterogeneous disorder characterized anovulation...
Polycystic ovary syndrome (PCOS) patients are at increased risk of pregnancy complications, which may impair outcome. Transfer fresh embryos after superovulation lead to abnormal implantation and placentation further increase for loss complications. Some preliminary data suggest that elective embryo cryopreservation followed by frozen–thawed transfer into a hormonally primed endometrium could result in higher clinical rate than achieved transfer. This study is multicenter, prospective,...
Abstract Polycystic ovary syndrome (PCOS) is one of the most common, heterogenous endocrine disorders and leading cause ovulatory obstacle associated with abnormal folliculogenesis. Dysfunction ovarian granulosa cells (GCs) recognized as a major factor that underlies follicle maturation. Angiopoietin‐like 4 (ANGPTL4) expression in GCs differs between patients without PCOS. However, role mechanism ANGPTL4 impaired follicular development are still poorly understood. Here, case–control study...
Are meiotic segregation patterns of reciprocal translocations affected by the combined effect chromosome type and carrier's sex? Interaction an acrocentric (Acr-ch) involved in translocation sex carrier influences proportion alternate for normal or balanced contents during autosomal translocations. Carriers are at a significantly increased risk fertility problems due to generation unbalanced gametes quadrivalent. Previous studies have reported that quadrivalent can be factors such as age...
Abstract Context Supraphysiological estradiol exposure after ovarian stimulation may disrupt embryo implantation fresh transfer. Women with polycystic ovary syndrome (PCOS), who usually overrespond to stimulation, have a better live birth rate frozen transfer (FET) than transfer; however, ovulatory women do not. Objective To evaluate whether the discrepancy in vs FET between these two populations is due variation response (i.e., peak level or oocyte number). Design, Setting, Patients,...
Objectives: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder with heterogeneous manifestations complex etiology. We used quantitative proteomics analysis based on mass spectrometry to identify the differences in profiles for follicular fluid obtained from patients or without PCOS explore possible mechanisms underlying PCOS. Methods: Follicular samples were collected infertile (n = 9) Total protein was extracted, quantitatively labeled tandem tag (TMT), analyzed...
Women with polycystic ovary syndrome (PCOS) commonly have intrinsic insulin resistance and are recommended to undergo an oral glucose tolerance test (OGTT) for diabetes screening. However, the effect of preconception impaired (IGT) on pregnancy is still unclear. To prospectively assess IGT outcomes. This was a secondary analysis multicenter randomized trial in 1508 women PCOS comparing live birth obstetric complications between fresh frozen embryo transfer. At baseline, fasting 2-hour levels...