A5036317252- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Reproductive Health and Technologies
- Prenatal Screening and Diagnostics
- Ectopic Pregnancy Diagnosis and Management
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Endometriosis Research and Treatment
- Renal and related cancers
- Gestational Diabetes Research and Management
- Hepatitis B Virus Studies
- Birth, Development, and Health
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Perovskite Materials and Applications
- Gynecological conditions and treatments
- Sperm and Testicular Function
- Liver Disease Diagnosis and Treatment
- Demographic Trends and Gender Preferences
- Pluripotent Stem Cells Research
- Chalcogenide Semiconductor Thin Films
- Epigenetics and DNA Methylation
- Hepatitis Viruses Studies and Epidemiology
- Cancer-related gene regulation
- Reproductive Health and Contraception
Northwest Women's and Children's Hospital
2016-2025
TU Dresden
2023-2024
Leibniz Institute for Solid State and Materials Research
2023-2024
Xi'an Jiaotong University
2019-2022
CARE Fertility
2022
Children's Hospital
2021
Health and Human Development (2HD) Research Network
2021
Shaanxi Provincial People's Hospital
2016
Shanxi Medical University
2016
First Affiliated Hospital of Xi'an Jiaotong University
2016
The transfer of fresh embryos is generally preferred over the frozen for in vitro fertilization (IVF), but some evidence suggests that frozen-embryo may improve live-birth rate and lower rates ovarian hyperstimulation syndrome pregnancy complications women with polycystic ovary syndrome.In this multicenter trial, we randomly assigned 1508 infertile who were undergoing their first IVF cycle to undergo either fresh-embryo or embryo cryopreservation followed by transfer. After 3 days...
Background Human reproduction depends on the fusion of a mature oocyte with sperm cell to form fertilized egg. The genetic events that lead arrest human maturation are unknown. Methods We sequenced exomes five members four-generation family, three whom had infertility due meiosis I arrest. performed Sanger sequencing candidate gene, TUBB8, in DNA samples from these members, additional family and 23 other affected families. expression TUBB8 all β-tubulin isotypes was assessed oocytes, early...
Connexins and pannexins are two protein families that play an important role in cellular communication. Pannexin 1 (PANX1), one of the members pannexin family, is a channel protein. It glycosylated forms three species, GLY0, GLY1, GLY2. Here, we describe four independent which mutations
Preimplantation embryo arrest (PREMBA) is a common cause of female infertility and recurrent failure assisted reproductive technology. However, the genetic basis PREMBA largely unrevealed. Here, using whole-exome sequencing data from 606 women experiencing compared with 2,813 controls, we performed population gene-based burden test identified candidate gene, karyopherin subunit α7 (KPNA7). In vitro studies showed that sequence variants reduced KPNA7 protein levels, impaired capacity for...
Abstract Interfacial modification is a key strategy for improving the performance of perovskite photovoltaic devices. While top surface active layer well established, engineering buried interface highly challenging. Here, spontaneous formation 1D/3D heterojunction at by incorporating choline acetate alongside precursors reported. Importantly, extensive spectroscopic and microscopic characterization solid‐state nuclear magnetic resonance experiments demonstrate phase‐pure 1D 3D domains. The...
However, the genetic basis for majority of patients resulting from abnormalities in these phenotypes remains to be elucidated.The cell division cycle 20 (CDC20, HGNC:1723) is coactivator anaphase-promoting complex/cyclosome (APC/ C) during mitosis, and plays a role maintaining genome by regulating spindle assembly checkpoints (Musacchio Hardwick, 2002).In oocytes, activation APC/C CDC20 key step homologue disjunction transition meiosis I II (Jones, 2011).CDC20 therefore an essential...
Abstract Background Oocyte maturation arrest and early embryonic are important reproductive phenotypes resulting in female infertility cause the recurrent failure of assisted technology (ART). However, genetic etiologies these infertility-related poorly understood. Previous studies have mainly focused on inherited mutations based large pedigrees or consanguineous patients. role de novo (DNMs) remains to be elucidated. Results To decipher DNMs ART with oocyte embryo defects, we explore...
In order to study the impact of procedures IVF/ICSI technology on sex ratio in China, we conducted this multi-center retrospective including 121,247 babies born 93,895 women China. There were 62,700 male and 58,477 female babies, making being 51.8% (Male: Female = 107∶100). univariate logistic regression analysis, was imbalance toward females 50.3% when ICSI preformed compared 47.7% IVF used (P<0.01). The significantly higher males transfers blastocyst (54.9%) thawed embryo (52.4%) with...
STUDY QUESTIONWhat factors does multivariate logistic regression show to be significantly associated with the likelihood of clinical pregnancy in vitrified–warmed embryo transfer (VET) cycles?
Objective: To investigate the characteristics and outcomes of low prognosis patients defined by POSEIDON criteria undergoing IVF treatment. Design: Retrospective cohort analysis. Setting: An clinic in a public hospital. Patients: 18,455 fresh aspirated cycles with subsequently frozen embryo transfer from Jan 2014 to 2017 single were included The categorized into 4 groups based on criteria: group 1: age < 35, antral follicle count (AFC) ≥ 5, number oocytes retrieved ≤ 9 previous cycle; 2:...
Can any new genetic factors responsible for early embryonic arrest in infertile patients be identified, together with the mechanism of pathogenic variants?We identified three homozygous variants F-box protein 43 gene (FBXO43) and studies on effects HEK293T cells mouse oocytes provided evidence a causal relation between FBXO43 female infertility.FBXO43, an inhibitor anaphase-promoting complex/cyclosome, mediates Metaphase II as component cytostatic factor oocytes. Both male Fbxo43 knockout...
There is a lack of information regarding the need to postpone conception after COVID-19 vaccination.To investigate time interval between first dose inactivated vaccine and in vitro fertilization (IVF) treatment as well rate pregnancy fresh embryo transfer.This cohort study was conducted at single public IVF center China. Female patients aged 20 47 years undergoing were consecutively registered from May 1 December 22, 2021, with follow-up until March 31, 2022. Patients SARS-CoV-2 infection...
To investigate the effects of endometrial thickness (EMT) on pregnancy outcomes hCG trigger day in fresh vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles.A total 42,132 cycles between 1 January 2013 31 December 2019 were included this retrospective cohort study. Data collected from five reproductive centers large academic or university hospitals China. All patients divided into different groups according to their day. Multivariate regression analysis, curve...
To determine whether gonadotropin-releasing hormone (GnRH) agonist downregulation combined with replacement therapy (HRT) can improve the reproductive outcomes in frozen-thawed embryo transfer cycles for older patients (aged 36-43 years) idiopathic recurrent implantation failure (RIF).This retrospective cohort study involved 549 undergoing their third cleavage-stage or blastocyst over a 5-year period (January 2015-December 2020) at Northwest Women's and Children's Hospital after vitro...
Abstract STUDY QUESTION Does an increased dosing of FSH improve the live birth rate as compared to standard in expected poor responders who undergo IVF? SUMMARY ANSWER In this trial, women with response allocated did not have a statistically significant increase cumulative births dose. WHAT IS KNOWN ALREADY Poor ovarian reserve leads worse IVF outcomes owing low number and quality oocytes. Clinicians often individualize dose using tests, including antral follicle count (AFC), basal plasma or...
Up to now, a number of studies have explored the influence blastocyst biopsy on maternal and neonatal outcomes, results been somewhat inconsistent. Therefore, aim this study was investigate whether is associated with an elevated risk hypertensive disorders pregnancy (HDP) other adverse perinatal outcomes during frozen embryo transfer (FET) cycles in singleton live births resulting from intracytoplasmic sperm injection (ICSI) women aged ≤ 35 years. A total 1,008 were involved January 2020...
Whether hepatitis B virus (HBV) infection impairs human infertility is unclear. The present retrospective case-controlled study investigated the impact of HBV on sperm parameters, ovarian stimulation, and outcomes in vitro fertilization (IVF) embryo transfer. A total 224 couples with at least one partner being HBsAg-seropositive undergoing their first IVF transfer cycle were identified, which included 77 female partners HBsAg-seropositive, 136 male 11 both HBsAg-seropositive. 448...