A5066055532- Microtubule and mitosis dynamics
- Atmospheric and Environmental Gas Dynamics
- Atmospheric Ozone and Climate
- Atmospheric chemistry and aerosols
- Geological and Geochemical Analysis
- Photosynthetic Processes and Mechanisms
- Advanced Aircraft Design and Technologies
- earthquake and tectonic studies
- Geothermal Energy Systems and Applications
- Fungal and yeast genetics research
- High-pressure geophysics and materials
- Cellular transport and secretion
- Cholinesterase and Neurodegenerative Diseases
- Cancer Treatment and Pharmacology
- Air Traffic Management and Optimization
- Vehicle emissions and performance
- Rocket and propulsion systems research
- Hydrocarbon exploration and reservoir analysis
- Heat Transfer and Optimization
- Geochemistry and Geologic Mapping
- Computational Drug Discovery Methods
- 14-3-3 protein interactions
- Combustion and flame dynamics
- Heat Transfer Mechanisms
- Plant Molecular Biology Research
Iowa State University
2018-2024
Banasthali University
2020-2024
Weizmann Institute of Science
2024
Institute for Research in Biomedicine
2024
Institut de Biochimie et Génétique Cellulaires
2024
Université de Bordeaux
2024
Centre National de la Recherche Scientifique
2024
G Pulla Reddy Dental College & Hospital
2012-2023
Teerthanker Mahaveer University
2021
Rabindranath Tagore Medical College
2016-2020
Background Human reproduction depends on the fusion of a mature oocyte with sperm cell to form fertilized egg. The genetic events that lead arrest human maturation are unknown. Methods We sequenced exomes five members four-generation family, three whom had infertility due meiosis I arrest. performed Sanger sequencing candidate gene, TUBB8, in DNA samples from these members, additional family and 23 other affected families. expression TUBB8 all β-tubulin isotypes was assessed oocytes, early...
This paper provides an overview of the National Jet Fuels Combustion Program led by Federal Aviation Administration, U.S. Air Force Research Laboratory, and NASA. The program follows from basic research Office Scientific results engine-company-led Rules Tools funded Force. overall objective this fuels was to develop combustion-related generic test modeling capabilities that can improve understanding impact fuel chemical composition physical properties on combustion, leading accelerating...
Links between the stratospheric thermal structure and ozone distribution are explored in Goddard Earth Observing System chemistry‐climate model (CCM). Ozone temperature fields validated using estimates based on observations. An experimental strategy is used to explore sensitivities of CCM alongside underlying general circulation (GCM) with specified from either observations or a chemistry‐transport (CTM), which uses same chemical modules as CCM. In CTM, upper biased low compared...
Abstract Under the Federal Aviation Administration’s (FAA) Climate Change Research Initiative (ACCRI), non-CO2 climatic impacts of commercial aviation are assessed for current (2006) and future (2050) baseline mitigation scenarios. The effects aircraft emissions examined using a number advanced climate atmospheric chemistry transport models. Radiative forcing (RF) estimates individual provided as range comparison against those published in literature. Preliminary results selected RF...
Microtubules are essential components of axon guidance machinery. Among β-tubulin mutations, only those in TUBB3 have been shown to cause primary errors guidance. All identified mutations TUBB2B result polymicrogyria, but it remains unclear whether can dysinnervation as a phenotype. We novel inherited heterozygous missense mutation that results an E421K amino acid substitution family who segregates congenital fibrosis the extraocular muscles (CFEOM) with polymicrogyria. Diffusion tensor...
The most frequent type of age-related dementia is Alzheimer's disease. To discover novel therapeutic agents for disease, a series substituted pyrimidine derivatives were synthesized and evaluated anti-Alzheimer's activity. All the compounds validated by 1HNMR, 13CNMR, HRMS to assess structural conformance newly compounds. then their in vivo acute toxicity study. Evaluation showed that none up 1000 mg/kg. After studies, subjected behavioral biochemical studies. Compound...
Deficiencies in the SBDS gene result Shwachman-Diamond syndrome (SDS), an inherited bone marrow failure associated with leukemia predisposition. encodes a highly conserved protein previously implicated ribosome biogenesis. Using human primary stromal cells (BMSCs), lymphoblasts, and skin fibroblasts, we show that stabilized mitotic spindle to prevent genomic instability. colocalized control BMSCs, fibroblasts bound purified microtubules. Recombinant microtubules vitro. We observed BMSCs...
Abstract Alzheimer’s disease (AD) is a multifaceted neurodegenerative condition. The pathogenesis of AD highly intricate and the apparent in aged population ~ 50–70 years old. Even after > 100 research, root origin its unclear, complex multifaceted. Herein, we have designed synthesized 9 novel molecules with three different heterocyclic scaffolds namely pyrrolidone-2-one, quinoline & indoline-2-one to imitate explore chemical space around donepezil. were evaluated for their potential...
Paclitaxel (Taxol) and the epothilones are antimitotic agents that promote assembly of mammalian tubulin stabilization microtubules. The competitively inhibit binding paclitaxel to brain tubulin, suggesting two types compounds share a common site in despite lack structural similarities. It is known does not stabilize microtubules formed vitro from Saccharomyces cerevisiae tubulin; thus, it would be expected affect yeast However, we found epothilone A B do stimulate formation purified...
We have successfully used mutagenesis to engineer Taxol (paclitaxel) binding activity in Saccharomyces cerevisiae tubulin. Taxol, a successful antitumor agent, acts by promoting tubulin assembly and stabilizing microtubules. Several structurally diverse antimitotic compounds, including the epothilones, compete with for mammalian microtubules, suggesting that these compounds share an overlapping site. However, has no effect on or microtubules from S. cerevisiae, whereas epothilone does. After...
Inclusion of kinetic isotope effects (KIEs) methane (CH 4 ) sinks (gaseous OH and Cl, soil microbes) has a significant effect on modeled distributions δ 13 C atmospheric CH . For given scenario surface sources corresponding values individual sources, the KIE due to uptake enriched by 1.18‰ in model's northern hemisphere (NH) (40°N) 1.16‰ southern (SH) (40°S) under steady state conditions January. The oxidation stratospheric Cl radicals further these at 0.99‰ 1.03‰, respectively. In vertical...
Projections of the recovery ozone layer are made with global atmospheric models using a specified time series mixing ratios depleting substances (ODSs) at lower boundary. This is calculated ratio observations, emission rates, and an estimate for lifetime. ODS destruction simulated atmospheric‐lifetime vary among because they depend on stratospheric transport mixing. We investigate balance between annual change in burden, its loss, input to atmosphere several models. Some produce realistic...
Aviation is an integral part of the global economic and transportation systems. In fact, aviation expansion outpaces growth. Projections indicate that over next 2 decades, demand for could grow to about 3 times its present level. This projected growth will likely result in higher emissions associated impacts on environment human health welfare, depending upon a variety factors (such as size mix operational fleet necessary meet stated demand, well mitigation steps include new technological...
Multidrug resistant non-fermenters are continuously increasing in hospital and ICU settings. One of the mechanisms developing drug resistance is possession efflux pump through which bacteria extrude antimicrobial agents other toxic substances. If these channels blocked or inhibited, increased concentration can be achieved a bacterial cell with optimal dose. Present study was aimed to investigate role curcumin as inhibitor (EPI) compare its activity known EPI like phe-arg-beta-naphthylamide...