A5054203955- Vestibular and auditory disorders
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Ophthalmology and Eye Disorders
- Visual perception and processing mechanisms
- melanin and skin pigmentation
- Ophthalmology and Visual Impairment Studies
- Retinal Diseases and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Connexins and lens biology
- Optical Coherence Tomography Applications
- Intraocular Surgery and Lenses
- Retinopathy of Prematurity Studies
- Retinal and Optic Conditions
- Cerebral Venous Sinus Thrombosis
- Retinal Imaging and Analysis
- Corneal surgery and disorders
- Tactile and Sensory Interactions
- Craniofacial Disorders and Treatments
- Ocular Disorders and Treatments
- Neuroscience of respiration and sleep
- Parkinson's Disease Mechanisms and Treatments
- Photoreceptor and optogenetics research
- Cellular transport and secretion
- Neonatal and fetal brain pathology
University of Leicester
2016-2025
Ulverscroft (United Kingdom)
2016-2025
Cooper Medical School of Rowan University
2022-2025
Leicester Royal Infirmary
2015-2024
Cooper University Health Care
2024
Cooper University Hospital
2021-2024
University of Nottingham
2002-2016
Queen's Medical Centre
2002-2016
Leibniz Institute for Neurobiology
2010
Hospital General de Niños Ricardo Gutierrez
2010
The mechanisms controlling axon guidance are of fundamental importance in understanding brain development. Growing corticospinal and somatosensory axons cross the midline medulla to reach their targets thus form basis contralateral motor control sensory input. projections appeared uncrossed patients with horizontal gaze palsy progressive scoliosis (HGPPS). In affected HGPPS, we identified mutations ROBO3 gene, which shares homology roundabout genes important developing Drosophila, zebrafish,...
Purpose.: Nystagmus, which can be infantile (congenital) or acquired, affects all ages. The prevalence of nystagmus in the general population is unknown. New genetic research and therapeutic modalities are emerging. Previous estimates have been based on wider ophthalmic epidemiologic studies within specific occupational age groups. authors carried out first study to specifically establish Leicestershire Rutland United Kingdom. Methods.: Three independent data sources identified persons with...
Purpose: To characterize the time course of normal foveal development in vivo term infants and young children using handheld spectral-domain optical coherence tomography (HH-SDOCT). Methods: We obtained 534 HH-SDOCT scans from 261 infants, children, adults with a mean age 4.9 years (range, 0–27 years). Each retinal layer was manually segmented ImageJ correlated gestational (GA) visual acuity (VA). The developmental trajectories each at fovea, parafovea, perifovea were calculated fractional...
To characterize the genotypic and phenotypic spectrum of foveal hypoplasia (FH).Multicenter, observational study.A total 907 patients with a confirmed molecular diagnosis albinism, PAX6, SLC38A8, FRMD7, AHR, or achromatopsia from 12 centers in 9 countries (n = 523) extracted publicly available datasets previously reported literature 384).Individuals availability OCT scans were identified between January 2011 March 2021. A genetic was by sequence analysis. Grading FH derived scans.Grade FH,...
To assess the safety and efficacy of AAV8-hCARp.hCNGB3 in participants with CNGB3-associated achromatopsia (ACHM).Prospective, phase 1/2 (NCT03001310), open-label, nonrandomized clinical trial.The study enrolled 23 adults children ACHM. In dose-escalation phase, adult were administered 1 3 dose levels worse-seeing eye (up to 0.5 mL). After a maximum tolerated was established adults, an expansion conducted ≥3 years old. All received topical oral corticosteroids. Safety parameters, including...
To investigate compliance with patching therapy and the dose-effect relationship in occlusion amblyopia by recording effective time using dose monitors (ODMs).Fifty-two children strabismic or mixed (Snellen equivalent, 6/12-6/48) were given optimal refractive correction randomly allocated for 12 weeks into three treatment groups: group 1, no patching; 2, prescribed 3 hours; 3, 6 hours. The of was monitored ODMs continuously. Visual acuity (VA) measured every LogMAR (logarithm minimum angle...
Abstract Objective Nystagmus consists of involuntary to and fro movements the eyes. Although studies have shown that memantine gabapentin can reduce acquired nystagmus, no drug treatment has been systematically investigated in congenital nystagmus. Methods We performed a randomized, double‐masked, placebo‐controlled study investigating effects on nystagmus over period 56 days. The primary outcome measure was logarithmic minimum angle resolution (logMAR) visual acuity; secondary measures were...
<h3>Introduction</h3> Chronic pain is highly prevalent and associated with a large burden of illness; there pressing need for safe, home-based, non-pharmacological, interventions. Virtual reality (VR) digital therapeutic known to be effective acute pain, but its role in chronic not yet fully elucidated. Here we present protocol the National Institute Health (NIH) Back Pain Consortium (BACPAC) VR trial that evaluates effectiveness three forms patients lower back (cLBP), form pain. <h3>Methods...
To investigate the optic nerve and macular morphology in patients with hypoplasia (ONH) using spectral-domain optical coherence tomography (SD OCT).
Schizophrenia is associated with several brain deficits, as well visual processing but clinically useful biomarkers are elusive. We hypothesized that retinal layer changes, noninvasively visualized using spectral-domain optical coherence tomography (SD-OCT), may represent a possible "window" to these abnormalities. A Leica EnvisuTM SD-OCT device was used obtain high-resolution central foveal B-scans in both eyes of 35 patients schizophrenia and 50 demographically matched controls. Manual...
PurposeTo determine feasibility of optic nerve head (ONH) imaging and to characterize ONH development in full-term infants without sedation using handheld spectral-domain optical coherence tomography (SD OCT).DesignProspective cross-sectional study.ParticipantsThree hundred fifty-two children aged between 1 day 13 years.MethodsAll participants were imaged SD OCT during a single scan session. The percentage successful scans was calculated. Interexaminer reproducibility differences right left...