A5016728238- FOXO transcription factor regulation
- Sarcoma Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Protein Degradation and Inhibitors
- Genetics and Neurodevelopmental Disorders
- Management of metastatic bone disease
- Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Bone Tumor Diagnosis and Treatments
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Tumors and Oncological Cases
- Renal and related cancers
- Cancer Mechanisms and Therapy
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Cardiac tumors and thrombi
- Melanoma and MAPK Pathways
- Hippo pathway signaling and YAP/TAZ
- Vascular Tumors and Angiosarcomas
- Musculoskeletal synovial abnormalities and treatments
- Immunotherapy and Immune Responses
- RNA Research and Splicing
University of California, Davis
2021-2025
California State University, Sacramento
2022-2024
UC Davis Comprehensive Cancer Center
2022
University of California Davis Medical Center
2022
University of California, Los Angeles
2004-2018
University of Illinois Urbana-Champaign
2008-2015
University of California, San Francisco
2015
University of Illinois Chicago
2008-2015
Illinois College
2007-2015
Ashland (United States)
2015
Soft tissue sarcomas (STS) are rare malignancies of mesenchymal cell origin that display a heterogenous mix clinical and pathologic characteristics. STS can develop from fat, muscle, nerves, blood vessels, other connective tissues. The evaluation treatment patients with requires multidisciplinary team demonstrated expertise in the management these tumors. complete NCCN Clinical Practice Guidelines Oncology (NCCN Guidelines) for Tissue Sarcoma provide recommendations diagnosis, evaluation,...
The mechanisms controlling axon guidance are of fundamental importance in understanding brain development. Growing corticospinal and somatosensory axons cross the midline medulla to reach their targets thus form basis contralateral motor control sensory input. projections appeared uncrossed patients with horizontal gaze palsy progressive scoliosis (HGPPS). In affected HGPPS, we identified mutations ROBO3 gene, which shares homology roundabout genes important developing Drosophila, zebrafish,...
Abstract Inherent and acquired therapeutic resistance in breast cancer remains a major clinical challenge. In human samples, overexpression of the oncogenic transcription factor FoxM1 has been suggested to be marker poor prognosis. this study, we report that confers epidermal growth receptor 2 monoclonal antibody Herceptin microtubule-stabilizing drug paclitaxel, both as single agents combination. altered microtubule dynamics protect tumor cells from paclitaxel-induced apoptosis. Mechanistic...
Abstract The forkhead box M1b (FoxM1b) transcription factor is over‐expressed in human cancers, and its expression often correlates with poor prognosis. Previously, using conditional knockout strains, we showed that FoxM1b essential for hepatocellular carcinoma (HCC) development. However, over‐expression of had only marginal effects on HCC progression. Here investigated the effect absence inhibitor Arf. We show transgenic an Arf‐null background drives hepatic fibrosis metastasis HCC....
Gastrointestinal stromal tumors (GIST) are the most common type of soft tissue sarcoma that occur throughout gastrointestinal tract. Most these caused by oncogenic activating mutations in KIT or PDGFRA genes. The NCCN Guidelines for GIST provide recommendations diagnosis, evaluation, treatment, and follow-up patients with tumors. These Insights summarize panel discussion behind recent important updates to guidelines, including revised systemic therapy options unresectable, progressive,...
Abstract Malignant neuroblastomas contain stem-like cells. These tumors also overexpress the Forkhead box transcription factor FoxM1. In this study, we investigated roles of FoxM1 in tumorigenicity neuroblastoma. We showed that depletion inhibits anchorage-independent growth and mouse xenografts. Moreover, knockdown induces differentiation neuroblastoma cells, suggesting plays a role maintenance undifferentiated progenitor population. inhibition malignant cells leads to downregulation...
Groundbreaking studies have linked the gut microbiome with immune homeostasis and antitumor responses. Mounting evidence has also demonstrated an intratumoral microbiome, including in soft tissue sarcomas (STS), although detailed characterization of STS is limited. We sought to characterize patients undergoing preoperative radiotherapy surgery, hypothesizing presence a distinct potentially clinically significant microbial signatures.We prospectively obtained tumor stool samples from adult...
Oxygen is a key modulator of many cellular pathways, but current devices permitting in vitro oxygen modulation fail to meet the needs biomedical research. A microfabricated insert for multiwell plates has been developed more effectively control temporal and spatial concentration better model physiological phenomena found vivo. The platform consists polydimethylsiloxane that nests into standard plate serves as passive microfluidic gas network with gas-permeable membrane aimed modulate...
Elevated expression of FoxM1 in breast cancer correlates with an undifferentiated tumor phenotype and a negative clinical outcome. However, role for regulating mammary differentiation was not known. Here, we identify another function FoxM1, the ability to act as transcriptional repressor, which plays important luminal epithelial progenitors. Regeneration glands elevated levels leads aberrant ductal morphology expansion progenitor pool. Conversely, knockdown results shift toward...
The forkhead box transcription factor FOXM1 is considered to be a promising target for cancer therapy. However, the significance of in tumors harboring mutation p53, which very common, unclear. In this study, we investigated efficacy FoxM1 targeting spontaneous p53-null using genetic ablation as well peptide inhibitor FOXM1. We show that conditional deletion inhibits growth thymic lymphoma and sarcoma cells. addition, induces apoptotic cell death tumors, accompanied by reduced expression...
FoxM1b is a cell cycle-regulated transcription factor, whose over-expression marker for poor outcome in cancers. Its transcriptional activation function requires phosphorylation by Cdk1 or Cdk2 that primes Plk1, which triggers association with the co-activator CBP. also possesses repression function. It represses mammary differentiation gene GATA3 involving DNMT3b and Rb. We investigated what determines two distinct functions of FoxM1b: repression. show Rb binds to C-terminal domain FoxM1b....
Abstract Background We have analyzed sex, race/ethnicity or socioeconomic disparities in the incidence of metastatic bone disease (MBD). Methods Patients with diagnosis MBD at presentation for five most common primary anatomical sites was extracted from Surveillance, Epidemiology, and End Results Census tract–level dataset. Mean different racial/ethnic groups were compared. The include “lung: ( n = 59 739), “prostate” 19 732), “breast” 16 244), “renal” 7718) “colon” 3068). There an increase...
High-grade complex karyotype soft tissue sarcomas (STS) are a heterogeneous and aggressive set of cancers that share common treatment strategy. Disease progression failure to respond anthracycline based chemotherapy, standard first-line treatment, is associated with poor patient outcomes. To address this, we investigated the contribution STS cancer stem cells (STS-CSCs) doxorubicin resistance. We identified positive correlation between CSC abundance IC
Abstract We discovered intronic mutations in two episodic ataxia type 2 (EA2) families: a four‐nucleotide GAGT deletion at IVS41+(3–6) and single nucleotide insertion (insT) IVS24+3. expressed minigenes harboring the cell lines to demonstrate exon skipping from mutation activation of cryptic splice donor site mutation. The identification these disease‐causing expands spectrum EA2 emphasizes importance sequences regulating gene expression. Ann Neurol 2005;57:131–135
Abstract This study describes the application of a unique strategy to identify breast cancer antigens [tumor-associated antigen (TAA)]. In mouse model, led identification growth factor receptor–bound protein 10 (Grb10) as newly identified TAA. Grb10 is signal transduction molecule associated with multiple transmembrane tyrosine kinase receptors. It was discovered by comparing microarrays cellular vaccines highly enriched for cells that induced immunity in tumor-bearing mice nonenriched...
Abstract Purpose The ideal local treatment modality for pelvic and sacral Ewing sarcoma (EWS) is controversial. Methods We present the data from American College of Surgeon's National Cancer Database (NCDB) Institute's Surveillance, Epidemiology End Result (SEER) database to investigate impact modalities on survival nonmetastatic sarcoma. Local includes “surgery,” “radiation,” a combination “surgery radiation.” Results A total 235 cases SEER 285 NCDB were analyzed. Patients with “localized”...
Approximately 5% of cancer patients in the United States presented with metastatic bone disease (MBD) at diagnosis. Current study explores disparities survival for MBD.Patients diagnosis MBD presentation five most common primary anatomical sites were extracted from Surveillance, Epidemiology, and End Results Census tract-level dataset (2010-2016). Kaplan-Meier Cox Proportional Hazard models used to evaluate survival, prognostic factors each cohort. Prognostic significance socioeconomic...
Dedifferentiated chondrosarcomas (DDCS) are aggressive tumors with poor outcomes. Treatment of localized DDCS is primarily surgical, though most patients present unresectable or metastatic disease. Systemic treatment options for advanced limited, and the benefits chemotherapy in this patient population remain controversial. Among other systemic therapy options, there emerging clinical evidence to support use immunotherapy DDCS. However, studies regarding efficacy limited. Here, we case a...