A5051980467- Sarcoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Advances in Oncology and Radiotherapy
- Medical Imaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- Management of metastatic bone disease
- Vascular Tumors and Angiosarcomas
- Lung Cancer Diagnosis and Treatment
- Patient Safety and Medication Errors
- Cardiac tumors and thrombi
- Bone Tumor Diagnosis and Treatments
- Colorectal and Anal Carcinomas
- Gastrointestinal Tumor Research and Treatment
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Neurofibromatosis and Schwannoma Cases
- Cancer survivorship and care
- Radiology practices and education
- Effects of Radiation Exposure
- Neurological disorders and treatments
- Glioma Diagnosis and Treatment
Washington University in St. Louis
2017-2023
Jewish Hospital
2019-2022
Barnes-Jewish Hospital
2019-2022
University of Washington
2015-2020
Seattle University
2019
Fred Hutch Cancer Center
2017
University of Illinois Chicago
2007-2012
Soft tissue sarcomas (STS) are rare malignancies of mesenchymal cell origin that display a heterogenous mix clinical and pathologic characteristics. STS can develop from fat, muscle, nerves, blood vessels, other connective tissues. The evaluation treatment patients with requires multidisciplinary team demonstrated expertise in the management these tumors. complete NCCN Clinical Practice Guidelines Oncology (NCCN Guidelines) for Tissue Sarcoma provide recommendations diagnosis, evaluation,...
The NCCN Guidelines for Soft Tissue Sarcoma provide recommendations the diagnosis, evaluation, treatment, and follow-up patients with soft tissue sarcomas. These Insights summarize panel discussion behind recent important updates to guidelines, including development of a separate distinct guideline gastrointestinal stromal tumors (GISTs); reconception management desmoid tumors; inclusion further diagnosis extremity/body wall, head/neck sarcomas, retroperitoneal sarcomas; modification...
Patients with metastatic sarcomas have poor outcomes and although the disease may be amenable to immunotherapies, information regarding immunologic profiles of soft tissue sarcoma (STS) subtypes is limited.The authors identified patients common STS subtypes: leiomyosarcoma, undifferentiated pleomorphic (UPS), synovial (SS), well-differentiated/dedifferentiated liposarcoma, myxoid/round cell liposarcoma. Gene expression, immunohistochemistry for programmed death protein (PD-1) death-ligand 1...
Treatment decisions for multimodal therapy in soft tissue sarcoma (STS) patients greatly depend on the differentiation between low-grade and high-grade tumors. We developed MRI-based radiomics grading models (G1) (G2/G3) STS.The study was registered at ClinicalTrials.gov (number NCT03798795). Contrast-enhanced T1-weighted fat saturated (T1FSGd), fat-saturated T2-weighted (T2FS) MRI sequences, tumor following French Federation of Cancer Centers Sarcoma Group obtained from pre-therapeutic...
Gastrointestinal stromal tumors (GIST) are the most common type of soft tissue sarcoma that occur throughout gastrointestinal tract. Most these caused by oncogenic activating mutations in KIT or PDGFRA genes. The NCCN Guidelines for GIST provide recommendations diagnosis, evaluation, treatment, and follow-up patients with tumors. These Insights summarize panel discussion behind recent important updates to guidelines, including revised systemic therapy options unresectable, progressive,...
Background The leading cause of mortality for patients with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome is development malignant peripheral nerve sheath tumor (MPNST), an aggressive soft tissue sarcoma. In setting NF1, this frequently arises from within its common and benign precursor, plexiform neurofibroma (PN). Transformation PN to MPNST challenging diagnose due difficulties in distinguishing cross-sectional imaging results intralesional heterogeneity resulting...
The basal ganglia-thalamo-cortical loop is an important neural circuit that regulates motor control. A key parameter the nervous system level of force to exert against object during tasks such as grasping. Previous studies indicate ganglia do not exhibit increased activity with increasing amplitude force, although these conclusions are based mainly on putamen. present study used functional magnetic resonance imaging investigate which regions in ganglia, thalamus, and cortex display when...
Stereotactic body radiation therapy (SBRT) has demonstrated clinical benefits for patients with metastatic and/or unresectable cancer. Technical considerations of treatment delivery and nearby organs at risk can limit the use SBRT in large tumors or those unfavorable locations. Spatially fractionated (SFRT) may address this limitation because technique deliver high-dose to discrete subvolume vertices inside a tumor target while restricting remainder safer lower dose. Indeed, SFRT, such as...
Background: In patients with soft-tissue sarcomas, tumor grading constitutes a decisive factor to determine the best treatment decision. Tumor is obtained by pathological work-up after focal biopsies. Deep learning (DL)-based imaging analysis may pose an alternative way characterize STS tissue. this work, we sought non-invasively differentiate into low-grade (G1) and high-grade (G2/G3) using DL techniques based on MR-imaging. Methods: Contrast-enhanced T1-weighted fat-saturated (T1FSGd) MRI...
To characterize changes in the soft-tissue sarcoma (STS) tumor immune microenvironment induced by standard neoadjuvant therapy with goal of informing immunotherapy trial design.Paired pre- and postneoadjuvant specimens were retrospectively identified for 32 patients STSs analyzed three modalities: multiplexed IHC, NanoString, RNA sequencing ImmunoPrism analysis.All patients, representing a variety STS histologic subtypes, received radiotherapy 21 (66%) chemotherapy prior to radiotherapy. The...
Abstract The basal ganglia (BG) are impaired in Parkinson's disease (PD), but it remains unclear which nuclei during the performance of motor tasks early‐stage PD. Therefore, this study was conducted to determine function abnormally, and whether cortical structures also affected by determined if cerebellar hyperactivity is found early course Blood oxygenation level dependent activation compared between 14 drug‐naïve PD patients controls performing two precision grip force using functional...
Background: In patients with soft-tissue sarcomas of the extremities, treatment decision is currently regularly based on tumor grading and size. The imaging-based analysis may pose an alternative way to stratify patients’ risk. this work, we compared value MRI-based radiomics expert-derived semantic imaging features for prediction overall survival (OS). Methods: Fat-saturated T2-weighted sequences (T2FS) contrast-enhanced T1-weighted fat-saturated (T1FSGd) were collected from two independent...
PurposeHerein we report the clinical and dosimetric experience for patients with metastases treated palliative simulation-free radiation therapy (SFRT) at a single institution.Methods MaterialsSFRT was performed institution. Multiple fractionation regimens were used. Diagnostic imaging used treatment planning. Patient characteristics as well planning time points collected. A matched cohort of conventional computed tomography simulation (CTRT) acquired to evaluate differences in time. SFRT...
A novel O-ring gantry can deliver stereotactic body radiation therapy (SBRT) with artificial intelligence-facilitated, CT-guided online plan adaptation. It gates mobile targets by optically monitoring skin surface motion. However, this gating solution has not been clinically validated. We conducted a trial to evaluate the feasibility of optical surface-guided for patients upper abdominal or lower thoracic malignancies treated SBRT on platform (NCT05030454).Ten who were prescribed target and...
Multi-view classification with limited sample size and data augmentation is a very common machine learning (ML) problem in medicine. With data, triplet network approach for two-stage representation has been proposed. However, effective training verifying the features from their suitability subsequent classifiers are still unsolved problems. Although typical distance-based metrics capture overall class separability of features, performance according to these does not always lead an optimal...