A5042233406- Cancer, Lipids, and Metabolism
- Advanced Radiotherapy Techniques
- Endometrial and Cervical Cancer Treatments
- Corrosion Behavior and Inhibition
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Prostate Cancer Treatment and Research
- Colorectal and Anal Carcinomas
- Lung Cancer Diagnosis and Treatment
- Concrete Corrosion and Durability
- Ovarian cancer diagnosis and treatment
- Glioma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Esophageal Cancer Research and Treatment
- Bladder and Urothelial Cancer Treatments
- Brain Metastases and Treatment
- Magnesium Oxide Properties and Applications
- Radiation Therapy and Dosimetry
- Colorectal Cancer Screening and Detection
- Cancer Cells and Metastasis
- Layered Double Hydroxides Synthesis and Applications
- Medical Imaging Techniques and Applications
Hubei Cancer Hospital
2025
Washington University in St. Louis
2020-2024
Sun Yat-sen University
2024
Sixth Affiliated Hospital of Sun Yat-sen University
2024
Zhejiang University
2019-2023
State Key Laboratory of Silicon Materials
2023
Saint Louis University
2023
Xi'an Technological University
2018-2022
Guangxi Medical University
2021
China International Science and Technology Cooperation
2020
Background The leading cause of mortality for patients with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome is development malignant peripheral nerve sheath tumor (MPNST), an aggressive soft tissue sarcoma. In setting NF1, this frequently arises from within its common and benign precursor, plexiform neurofibroma (PN). Transformation PN to MPNST challenging diagnose due difficulties in distinguishing cross-sectional imaging results intralesional heterogeneity resulting...
// Shu-Jen Chen 1, 2, 3, * , Hsuan Liu Chun-Ta Liao 4, Po-Jung Huang 5 Yi 2 An Hsu 3 Petrus Tang Yu-Sun Chang Hua-Chien Tzu-Chen Yen 6 1 Department of Biomedical Sciences, Gung University, Taoyuan, 33302, Taiwan Genomic Core Laboratory, Graduate Institute 4 Otorhinolaryngology, Memorial Hospital, 33305, Bioinformatics Nuclear Medicine, These authors have contributed equally to this work Correspondence to: Yen, e-mail: yen1110@adm.cgmh.org.tw Chen, hcchen@actgenomics.com Keywords:...
Cancer patients with high serum squamous cell carcinoma antigen (SCCA1/SERPINB3) are commonly associated treatment resistance and poor prognosis. Despite being a clinical biomarker, the modulation of SERPINB3 in tumor immunity is poorly understood. We found positive correlations CXCL1/8, S100A8/A9 myeloid infiltration through RNAseq analysis human primary cervix tumors. Induction resulted increased CXCL1/8 S100A8/A9, which promoted monocyte MDSC migration vitro. In mouse models,...
Abstract The purpose of this study was to determine if radiation (RT)-resistant cervical cancers are dependent upon glutamine metabolism driven by activation the PI3K pathway and test whether mutation predicts radiosensitization inhibition metabolism. Cervical cancer cell lines with without mutations, including SiHa PTEN−/− cells engineered CRISPR/Cas9, were used for mechanistic studies performed in vitro presence absence starvation glutaminase inhibitor, telaglenastat (CB-839). These...
Anticorrosive coatings prepared by sol-gel derived approaches have become an emergent research area in the field of corrosion prevention materials. Furthermore, enhanced coating thickness can greatly improve barrier effect coatings, thus influencing their service life industrial applications. Here, we propose preparation a two-layer system using low-cost method. The structure was composed first underlying layer incorporated with silica and titania powder as filler pigment materials, second...
Abstract The endogenous lysosomal cysteine protease inhibitor SERPINB3 (squamous cell carcinoma antigen 1, SCCA1) is elevated in patients with cervical cancer and other malignancies. High serum prognostic for recurrence death following chemoradiation therapy. Cervical cells genetically lacking are more sensitive to ionizing radiation (IR), suggesting this plays a role therapeutic response. Here we demonstrate that -deficient have enhanced sensitivity IR-induced death. Knock out of sensitizes...
Abstract Obesity induces numerous physiological changes that can impact cancer risk and patient response to therapy. Obese patients with cervical have been reported superior outcomes following chemoradiotherapy, suggesting free fatty acids (FFA) might enhance radiotherapy. Here, using preclinical models, we show monounsaturated diunsaturated FFAs (uFFA) radiosensitize through a novel p53-dependent mechanism. UFFAs signaled PPARγ p53 promote lipid uptake, storage, metabolism after Stable...
The objective of this study is to investigate the association among polymorphisms XRCC1 gene, smoking, drinking, family history tumors, and risk colorectal cancer (CRC) in population Han nationality Jiangsu Province, China. A case–control 320 patients with CRC 350 cancer-free subjects as a control group was conducted. three polymorphic sites, codons 194, 280, 399, genes were analyzed by PCR-RFLP. We find that heavy smoking (>500 cigarettes per year) significantly increased susceptibility (OR...
Abstract Leber hereditary optic neuropathy (LHON) is a degenerative disease of the nerve associated with one three mitochondrial DNA (mtDNA) m.3460G>A, m.11778G>A and m.14484T>C mutations. Although several procedures are available to genotype these mutations, quantitative approaches rapid, low-cost easy handle advantages for LHON mtDNA mutations rarely reported. Here, we firstly developed “one-step” tetra-primer amplification-refractory mutation system (T-ARMS) PCR qualitative...