A5022549128- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- Glioma Diagnosis and Treatment
- Mathematical Biology Tumor Growth
- Prostate Cancer Diagnosis and Treatment
- Vitamin D Research Studies
- Cancer, Hypoxia, and Metabolism
- Radiation Therapy and Dosimetry
- Vitamin C and Antioxidants Research
- RNA Research and Splicing
- Neuroblastoma Research and Treatments
- Adenosine and Purinergic Signaling
- Cancer Research and Treatments
- Computational Drug Discovery Methods
- Metabolomics and Mass Spectrometry Studies
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Medical Imaging Techniques and Applications
- Drug Transport and Resistance Mechanisms
- Estrogen and related hormone effects
Columbia University Irving Medical Center
2018-2025
Texas Health Dallas
2019-2023
Presbyterian Hospital
2023
Penn Presbyterian Medical Center
2023
Columbia University
2017-2020
NewYork–Presbyterian Hospital
2017-2018
Boston University
2004-2018
Harvard University Press
2016
Broad Institute
2016
Harvard University
2013-2014
Silver enhances the activity of a wide range antibiotics and broadens spectrum vancomycin, rendering it effective against Gram-negative bacteria.
Mitochondrial dysfunction and oxidative damage induced by bactericidal antibiotics in mammalian cells may be alleviated an antioxidant or prevented preferential use of bacteriostatic antibiotics.
Wilms Tumor, the most common pediatric kidney cancer, evolves from failure of terminal differentiation embryonic kidney. Here we show that overexpression heterochronic regulator Lin28 during development in mice markedly expands nephrogenic progenitors by blocking their final wave differentiation, ultimately resulting a pathology highly reminiscent tumor. Using lineage-specific promoters to target specific cell types, observed tumor only when is aberrantly expressed multiple derivatives...
Abstract Purpose: Intratumoral immunosuppression mediated by myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM) represents a potential mechanism of immune checkpoint inhibitor (ICI) resistance in solid tumors. By promoting TAM MDSC infiltration, IL1β may drive adaptive innate renal cell carcinoma (RCC) other tumor types. Experimental Design: Using the RENCA model RCC, we evaluated clinically relevant combinations anti-IL1β plus either anti-PD-1 or multitargeted...
Cancer patients with high serum squamous cell carcinoma antigen (SCCA1/SERPINB3) are commonly associated treatment resistance and poor prognosis. Despite being a clinical biomarker, the modulation of SERPINB3 in tumor immunity is poorly understood. We found positive correlations CXCL1/8, S100A8/A9 myeloid infiltration through RNAseq analysis human primary cervix tumors. Induction resulted increased CXCL1/8 S100A8/A9, which promoted monocyte MDSC migration vitro. In mouse models,...
Multiple phase I-II clinical trials have reported on the efficacy and safety of prostate stereotactic body radiotherapy (SBRT) for treatment cancer. However, few outcomes SBRT using periprostatic hydrogel spacer (SpaceOAR; Augmenix). Herein, we report from our institutional experience with SpaceOAR placement. Fifty men low- or intermediate-risk cancer treated at a single institution linear accelerator-based to 3625 cGy in 5 fractions, without androgen deprivation therapy (ADT) were included....
Abstract Background: Spatial integration of metabolic pathways with single cell-level transcriptomic data in human tumor and normal tissue may elucidate mechanisms supporting tumorigenesis for therapeutic targeting. The suppressive adenosine signaling pathway is an emerging potential target combination radiotherapy. This study aims to create situ map the non-small cell lung cancer (NSCLC) adjacent tissue. We seek define how distinct cellular compartments cooperate contribute within...
Abstract Introduction: Radiation therapy (RT) induces adenosine signaling by releasing ATP in the tumor microenvironment (TME), promoting immune suppression and progression. This study investigates how RT impacts cell infiltration a preclinical model of non-small lung cancer (NSCLC). Using immunophenotyping tumor-infiltrating cells LLC1 murine model, we aim to explore potential targeting pathway combination with enhance antitumor immunity clinical outcomes. Methods: (5 x 105) were implanted...
This study quantitatively evaluates bladder changes and their dosimetric impact during the on-couch adaptive process on a commercial CBCT-based online radiotherapy (CT-gART) platform. Data from 183 fractions of ten patients receiving ART for pelvic cancers were analyzed retrospectively. Bladder contours automatically generated revised by an expert each pair planning verification CBCTs. shape assessed using geometric boundary distance metrics. A deformable image registration (DIR) workflow...
Abstract Purpose: Tumor irradiation generates high levels of extracellular ATP that is metabolized to suppressive adenosine implicated in cancer progression. The relative contribution host and cell-derived downstream signaling radioresistance unclear. Methods: In a murine model breast (EO771), we measured the expression proteins: CD73 metabolizes AMP receptors, A2aR A2bR by flow cytometry. We concentration LC-MS supernatants WT tumor cells those lack (CD73-/-) grown vitro. To understand...
We aim to test the hypothesis that neurovascular bundle (NVB) displacement by rectal hydrogel spacer combined with NVB delineation as an organ at risk (OAR) is a feasible method for NVB-sparing stereotactic body radiotherapy.Thirty-five men low- and intermediate-risk prostate cancer who underwent placement pre-, post-spacer MRI studies were treated SBRT (36.25 Gy in five fractions). A radiologist contoured on both pre- T2W sequences then registered CT simulation scan radiation treatment...
<h2>Abstract</h2><h3>Purpose</h3> The emerging online adaptive radiotherapy (OART) treatment strategy based on cone-beam computed tomography allows for real-time replanning according to a patient's current anatomy. However, implementing this procedure requires new approach across the care path and monitoring of "black box" adaptation process. This study identifies high-risk failure modes (FMs) associated with AI-driven OART proposes an interdisciplinary workflow mitigate potential medical...