A5011992517- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Histone Deacetylase Inhibitors Research
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Breast Cancer Treatment Studies
- Epigenetics and DNA Methylation
- Cancer survivorship and care
- Breast Implant and Reconstruction
- TGF-β signaling in diseases
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Neuroendocrine Tumor Research Advances
- MicroRNA in disease regulation
- Radiation Dose and Imaging
- Developmental Biology and Gene Regulation
- Management of metastatic bone disease
Columbia University Irving Medical Center
2016-2025
Columbia University
2014-2024
James J. Peters VA Medical Center
2024
Montefiore Medical Center
2024
Albert Einstein College of Medicine
2024
Montefiore Einstein Comprehensive Cancer Center
2024
Herbert Irving Comprehensive Cancer Center
2015-2024
St. Francis Hospital
2024
NewYork–Presbyterian Hospital
2016-2022
New York Hospital Queens
2019-2022
The zebrafish EGF-CFC gene one-eyed pinhead (oep) is required zygotically for the formation of ventral neuroectoderm, endoderm, and prechordal plate. Here we report that embryos lacking both maternal zygotic Oep activity are defective in germ layer formation, organizer development, positioning anterior-posterior axis. An identical phenotype displayed by double mutants nodal-related genes squint cyclops. Mutations oep eliminate response to Squint Cyclops overexpression but suppressed...
The neuronal-specific Elav-like proteins (HuD, Hel-N, and HuC) contain three RNP-type concensus motifs bind to AU-rich elements. We have identified cloned a fourth member of this family (HuR) that is expressed in wide variety cell types. purified recombinant protein binds avidly the element c-fos interleukin-3 mRNAs. In case element, HuR core 27 nucleotides AUUUA, AUUUUA, AUUUUUA motifs. Mutational analysis has shown all AU are required for maximal binding.
Although radiation is widely used to treat cancers, resistance mechanisms often develop and involve activation of DNA repair inhibition apoptosis. Therefore, compounds that sensitize cancer cells via alternative cell death pathways are valuable. We report here ferroptosis, a form nonapoptotic driven by lipid peroxidation, partly responsible for radiation-induced death. Moreover, we found small molecules activating ferroptosis through system xc– or GPX4 synergize with induce in several types...
Abstract Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable inhibiting via activity enzyme glutathione peroxidase 4 (GPX-4), generated directly from sulfur-containing amino acid cysteine, and indirectly methionine transsulfuration pathway. Herein we show that cysteine deprivation (CMD) can synergize with GPX4 inhibitor RSL3 to increase ferroptotic cell death in both murine human...
O6-methylguanine-DNA methyltransferase (MGMT [OMIM 156569]) promoter methylation (mMGMT) is predictive of response to alkylating chemotherapy for glioblastomas and routinely used guide treatment decisions. However, the utility MGMT status low-grade anaplastic gliomas remains unclear due molecular heterogeneity lack sufficiently large data sets.
Previous comparative effectiveness studies have not demonstrated a benefit of proton beam therapy (PBT) compared with intensity-modulated radiation (IMRT) for prostate cancer. An updated comparison GI and genitourinary (GU) toxicity is needed.
The TGF-β signals Nodal, Activin, GDF1, and Vg1 have been implicated in mesoderm induction left-right patterning. Nodal Activin both activate receptors, but only requires EGF-CFC coreceptors for signaling. We report that GDF1 signaling zebrafish also depends on proteins, not signals. Correspondingly, we find Xenopus bind to signal through receptors the presence of proteins. These results establish multiple converge receptor/EGF-CFC complexes suggest a more widespread requirement than...
HuD is a human neuronal specific RNA-binding protein. In this study we have purified and examined its RNA binding properties in detail. binds to mRNAs that contain an AU-rich element with high affinity. the case of c-fos element, 27-nucleotide core comprising AUUUA, AUUUUA, AUUUUUA motifs. Mutation any two these motifs abrogates binding. contains tandem recognition (RRM), basic domain, third RRM. Deletion analysis has shown only first second RRMs are essential for Thus, support idea...
Members of the EGF-CFC family play essential roles in embryonic development and have been implicated tumorigenesis. The TGFβ signals Nodal Vg1/GDF1, but not Activin, require coreceptors to activate Activin receptors. We report that signaling antagonist Lefty also acts through an EGF-CFC-dependent mechanism. inhibits Vg1 signaling, signaling. genetically interacts with proteins competes for binding these coreceptors. Chimeras between or identify a 14 amino acid region confers independence...
// Haiying Cheng 1 , Zhenfeng Zhang 2 Ruth Rodriguez-Barrueco 3 Alain Borczuk 4 Huijie Liu Jiyang Yu 5, 7 Jose M. Silva Simon K. 6 Roman Perez-Soler Balazs Halmos 1, 8 Department of Oncology, Albert Einstein College Medicine Yeshiva University/Montefiore Medical Center, Bronx, NY, USA Sun Yat-Sen University Cancer State Key Laboratory Oncology in South China, Collaborative Innovation Center for Medicine, Imaging and Image-Guided Therapy, Guangzhou, China Icahn School at Mount Sinai, New...
Abstract Purpose: While MGMT promoter methylation (mMGMT) is predictive of response to alkylating chemotherapy and guides treatment decisions in glioblastoma, its role grade 2 3 glioma remains unclear. Recent data suggest that mMGMT prognostic progression-free survival 1p/19q-codeleted oligodendrogliomas, but an effect on overall (OS) has not been demonstrated. Experimental Design: We identified patients with newly diagnosed gliomas known status the National Cancer Database from 2010 2019....
Introduction: Locally advanced non-small cell lung cancer (NSCLC) is highly resistant to chemoradiotherapy, and many patients experience chronic stress. Studies that suggest stimulation of β-adrenergic receptors (β-AR) promotes tumor invasion therapy resistance. We investigated whether β-AR inhibition with beta-blockers acts as a chemotherapy radiation sensitizer in vitro treated chemoradiation for locally NSCLC. Methods: the effects non-selective beta-blocker propranolol on two human...
Genomic analysis in neurooncology has underscored the importance of understanding patterns survival different molecular subtypes within gliomas and their responses to treatment. In particular, diffuse are now principally characterized by mutation status (IDH1 1p/19q codeletion), yet there remains a paucity information regarding prognostic value markers extent resection (EOR) on survival. Furthermore, given modern emphasis rather than histological diagnosis, it is important examine effect...
Abstract Background: Spatial integration of metabolic pathways with single cell-level transcriptomic data in human tumor and normal tissue may elucidate mechanisms supporting tumorigenesis for therapeutic targeting. The suppressive adenosine signaling pathway is an emerging potential target combination radiotherapy. This study aims to create situ map the non-small cell lung cancer (NSCLC) adjacent tissue. We seek define how distinct cellular compartments cooperate contribute within...
Recent public health research has consistently reported that self-identified multiracial adolescents tend to display more problem behaviors and psychological difficulties than monoracial adolescents. Relying on insights from qualitative analyses using small or clinical samples interpret these empirical patterns, studies implicitly assume a pejorative stance toward adolescents' self-identification. Building the social arguments underlying Park's Stonequist's seminal discussions of "marginal...
We investigated effects of genetic alterations in epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and Kirsten rat sarcoma viral oncogene homolog (KRAS) on overall survival (OS) local control after stereotactic radiosurgery for brain metastases non-small cell lung cancer (NSCLC).A cohort 89 out 262 NSCLC patients (2003-2013) treated with gamma knife had genotyping available were selected as our study population.Median follow-up was 12 months. Median OS rates the...
The Gamma Knife (GK) Icon (Elekta AB) uses a cone-beam computed tomography (CBCT) scanner and an infrared camera system to support the delivery of frameless stereotactic radiosurgery (SRS). There are limited data on patients treated with GK (GKRS).To describe early experience, process, technical details, short-term outcomes GKRS at our institution.We reviewed patient selection described workflow in detail, including image acquisition, treatment planning, mask-based immobilization, CBCT...