A5058562431- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- T-cell and Retrovirus Studies
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Histone Deacetylase Inhibitors Research
- Eosinophilic Disorders and Syndromes
- PI3K/AKT/mTOR signaling in cancer
- Protein Degradation and Inhibitors
- Mesenchymal stem cell research
- Lymphoma Diagnosis and Treatment
- Vector-Borne Animal Diseases
- Epigenetics and DNA Methylation
- Hematological disorders and diagnostics
- Cancer Genomics and Diagnostics
- Animal Disease Management and Epidemiology
- RNA Interference and Gene Delivery
- Bone and Joint Diseases
- COVID-19 and healthcare impacts
- CNS Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
Albert Einstein College of Medicine
2016-2025
Montefiore Medical Center
2016-2025
The Bronx Defenders
2020-2024
Cancer Institute (WIA)
2023
Montefiore Einstein Comprehensive Cancer Center
2022
Yeshiva University
2015
Dana-Farber Cancer Institute
2008-2015
Brigham and Women's Hospital
2008-2014
Harvard University
2009-2014
Harvard University Press
2010
The zebrafish EGF-CFC gene one-eyed pinhead (oep) is required zygotically for the formation of ventral neuroectoderm, endoderm, and prechordal plate. Here we report that embryos lacking both maternal zygotic Oep activity are defective in germ layer formation, organizer development, positioning anterior-posterior axis. An identical phenotype displayed by double mutants nodal-related genes squint cyclops. Mutations oep eliminate response to Squint Cyclops overexpression but suppressed...
Abstract Axicabtagene ciloleucel (Axi-cel) is a CD-19 Chimeric Antigen Receptor T cell therapy approved for the treatment of relapsed/refractory diffuse large B lymphoma. We treated ten patients with DLBCL post-FDA approval in an inner-city tertiary center Bronx. Eight (80%) had received ≥ 3 lines therapy, six prior radiation, and seven recurrent disease after autologous hematopoietic stem transplant (AHCT). Our cohort included one patient HIV, two hepatitis B, CNS involvement Axi-cel led to...
ABSTRACT Spemann’s organizer plays an essential role in patterning the vertebrate embryo. During gastrulation, cells involute and form prechordal plate anteriorly notochord more posteriorly. The fate mapping gene expression analyses zebrafish presented this study reveal that anteroposterior polarity is already initiated before gastrulation. Prechordal progenitors reside close to blastoderm margin express homeobox goosecoid, whereas precursors are located further from floating head....
Yu-Ting Yan, Kira Gritsman, Jixiang Ding, Rebecca D. Burdine, JoMichelle Corrales, Sandy M. Price, William S. Talbot, Alexander F. Schier, and Michael Shen Center for Advanced Biotechnology Medicine (CABM) Department of Pediatrics, University Dentistry New Jersey–Robert Wood Johnson Medical School, Piscataway, Jersey 08854 USA; Developmental Genetics Program, Skirball Institute Biomolecular Medicine, Cell Biology, York School York, 10016 USA
We identified amplification of RICTOR, a key component the mTOR complex 2 (mTORC2), as sole actionable genomic alteration in an 18-year-old never-smoker with lung adenocarcinoma. Amplification RICTOR occurs 13% cancers (1,016 cases) The Cancer Genome Atlas and at similar frequency independent cohort 1,070 patients by profiling. In latter series, 11% cases harbored only relevant alteration. Its oncogenic roles were suggested decreased cancer cell growth both vitro vivo ablation, transforming...
The surface molecule interleukin-1 receptor accessory protein (IL1RAP) is consistently overexpressed across multiple genetic subtypes of acute myeloid leukemia (AML) and other malignancies, including at the stem cell level, emerging as a novel therapeutic target. However, cell-intrinsic functions IL1RAP in AML cells are largely unknown. Here, we show that targeting via RNA interference, deletion, or antibodies inhibits pathogenesis vitro vivo, without perturbing healthy hematopoietic...
Abstract The bone marrow microenvironment influences malignant hematopoiesis, but how it promotes leukemogenesis has not been elucidated. In addition, the role of stroma in regulating clinical responses to DNA methyltransferase inhibitors (DNMTi) is also poorly understood. this study, we conducted a methylome analysis marrow–derived stromal cells from myelodysplastic syndrome (MDS) patients and observed widespread aberrant cytosine hypermethylation occurring preferentially outside CpG...
The genes encoding RAS family members are frequently mutated in juvenile myelomonocytic leukemia (JMML) and acute myeloid (AML). proteins difficult to target pharmacologically; therefore, targeting the downstream PI3K RAF/MEK/ERK pathways represents a promising approach treat RAS-addicted tumors. p110α isoform of (encoded by Pik3ca) is an essential effector oncogenic KRAS murine lung tumors, but it unknown whether contributes leukemia. To specifically examine role hematopoiesis leukemia, we...
Familial platelet disorder (FPD) is associated with germline RUNX1 mutations, establishing a preleukemic state and increasing the risk of developing leukemia. Currently, there are no intervention strategies to prevent leukemia progression. Single-cell RNA sequencing (n = 10) combined functional analysis samples from patients RUNX1-FPD > 75) revealed that FPD hematopoietic stem progenitor cells (HSPCs) displayed increased myeloid differentiation suppressed megakaryopoiesis because activation...
Skeletal stem cells have been isolated from various tissues, including periosteum and bone marrow, where they exhibit key functions in biology hematopoiesis, respectively. The role of periosteal skeletal regeneration healing has extensively studied, but their ability to contribute the marrow stroma is still under debate. In present study, we characterized a whole transplantation model that mimics initial necrosis fatty infiltration seen after injury. Using this lineage tracing approach,...
Acute myeloid leukemia (AML) that evolves from myeloproliferative neoplasm (MPN) is known as post-MPN AML. Current treatments don't significantly extend survival beyond 12 months. BCL-xL has been found to be overexpressed in leucocytes MPN patients, making it a potential therapeutic target. We investigated the role of AML and tested efficacy DT2216, platelet-sparing proteolysis-targeting chimera (PROTAC), preclinical models BCL2L1, gene encoding BCL-xL, expressed at higher levels patients...
Abstract The tumour suppressor PTEN, which antagonizes PI3K signalling, is frequently inactivated in haematologic malignancies. In mice, deletion of PTEN haematopoietic stem cells (HSCs) causes perturbed haematopoiesis, myeloproliferative neoplasia (MPN) and leukaemia. Although the roles isoforms have been studied PTEN-deficient tumours, their individual HSCs are unknown. Here we show that when delete using Mx1–Cre system, p110β ablation prevents MPN, improves HSC function suppresses...
Many cytokines and chemokines that are important for hematopoiesis activate the PI3K signaling pathway. Because this pathway is frequently mutated activated in cancer, inhibitors have been developed treatment of several malignancies now being tested clinic combination with chemotherapy. However, role adult hematopoietic stem cells (HSCs), particularly during stress, still unclear. We previously showed individual catalytic isoforms p110α p110β dispensable roles HSC function, suggesting...