A5089725072- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Cancer Cells and Metastasis
- Acute Myeloid Leukemia Research
- Bone and Joint Diseases
- Digestive system and related health
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Microtubule and mitosis dynamics
- Pancreatic function and diabetes
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Pluripotent Stem Cells Research
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- RNA Interference and Gene Delivery
- Protease and Inhibitor Mechanisms
- Neonatal Respiratory Health Research
- Bone health and treatments
- Animal Nutrition and Physiology
- Peptidase Inhibition and Analysis
- Nutrition, Genetics, and Disease
Albert Einstein College of Medicine
2017-2025
Kyushu University
2009-2022
Japan Science and Technology Agency
2011-2014
Abstract Although the mammalian intestinal epithelium manifests robust regenerative capacity after various cytotoxic injuries, underlying mechanism has remained unclear. Here we identify cyclin-dependent kinase inhibitor p57 as a specific marker for quiescent cell population located around +4 position of crypts. Lineage tracing reveals that + cells serve enteroendocrine/tuft precursors under normal conditions but dedifferentiate and act facultative stem to support regeneration injury....
Skeletal stem cells have been isolated from various tissues, including periosteum and bone marrow, where they exhibit key functions in biology hematopoiesis, respectively. The role of periosteal skeletal regeneration healing has extensively studied, but their ability to contribute the marrow stroma is still under debate. In present study, we characterized a whole transplantation model that mimics initial necrosis fatty infiltration seen after injury. Using this lineage tracing approach,...
Dormant cancer cells known as disseminated tumor (DTCs) are often present in bone marrow of breast patients. These DTCs thought to be responsible for the incurable recurrence cancer. The mechanism underlying long-term maintenance remains unclear, however. Here, we show that Fbxw7 is essential dormancy. Genetic ablation disrupted quiescence DTCs, rendering them proliferative, mouse xenograft and allograft models. Fbxw7-deficient were significantly depleted by treatment with paclitaxel,...
Abstract Toxoplasmosis is a rare but rapidly fatal complication that can occur following hematopoietic stem cell transplantation (HSCT). Over 17‐yr period at our institutions, definite diagnosis of toxoplasmosis was made in only two 925 allogeneic HSCT recipients (0.22%) and none 641 autologous recipients. These patients received conventional conditioning regimen followed by from an HLA‐matched donor; however, they developed severe graft‐vs.‐host disease, which required intensive...
We describe a case of encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease (GVHD) occurring after allogeneic bone marrow transplanation (BMT) for myelodysplastic syndrome. Immunosuppressive therapy, consisting therapeutic dose cyclosporine A and maintenance methylprednisolone, was effective in treating symptoms. Although central nervous system GVHD is very rare remains controversial, presentation neurological symptoms BMT warrants consideration the...
SUMMARY Skeletal stem cells have been isolated from various tissues, including periosteum and bone marrow, where they exhibit key functions in biology hematopoiesis, respectively. The role of periosteal skeletal regeneration healing has extensively studied, but their ability to contribute the marrow stroma is still under debate. In present study, we characterized a whole transplantation model that mimics initial necrosis fatty infiltration seen after injury. Using this lineage tracing...
Skeletal stem cells have been isolated from various tissues, including periosteum and bone marrow, where they exhibit key functions in biology hematopoiesis, respectively. The role of periosteal skeletal regeneration healing has extensively studied, but their ability to contribute the marrow stroma is still under debate. In present study, we characterized a whole transplantation model that mimics initial necrosis fatty infiltration seen after injury. Using this lineage tracing approach,...
Skeletal stem cells have been isolated from various tissues, including periosteum and bone marrow, where they exhibit key functions in biology hematopoiesis, respectively. The role of periosteal skeletal regeneration healing has extensively studied, but their ability to contribute the marrow stroma is still under debate. In present study, we characterized a whole transplantation model that mimics initial necrosis fatty infiltration seen after injury. Using this lineage tracing approach,...
Abstract Haematopoietic stem cells (HSCs) reside in specialized microenvironments, also referred to as niches, and it has been widely believed that HSC numbers are determined by the niche size alone 1–5 . However, vast excess of number over HSCs raises questions about this model. We initially established a mathematical model availability occupancy, which predicted restricted at both systemic local levels. To address question experimentally, we developed femoral bone transplantation system,...