A5037451481- Plant responses to elevated CO2
- Plant Water Relations and Carbon Dynamics
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cardiac Valve Diseases and Treatments
- Seed Germination and Physiology
- Synthesis and Properties of Aromatic Compounds
- Pharmacy and Medical Practices
- Organic Electronics and Photovoltaics
- Luminescence and Fluorescent Materials
- Plant Stress Responses and Tolerance
- Ecology and Vegetation Dynamics Studies
- Epigenetics and DNA Methylation
- Aortic Disease and Treatment Approaches
- Atmospheric chemistry and aerosols
- Photosynthetic Processes and Mechanisms
- Light effects on plants
- Crystallography and molecular interactions
- Infective Endocarditis Diagnosis and Management
- Fullerene Chemistry and Applications
- Allelopathy and phytotoxic interactions
- Porphyrin and Phthalocyanine Chemistry
- Plant tissue culture and regeneration
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
Keio University
2001-2025
Tokyo Medical and Dental University
2021-2024
National Institute for Environmental Studies
2014-2024
Kyushu University
2003-2023
University of Manchester
2011-2022
Center for Systems Biology
2021-2022
Harvard University
2021-2022
Tokyo Metropolitan University
2002-2021
Keio University Hospital
2015-2021
RELX Group (United States)
2019
Glucose metabolism is remodeled in cancer, but the global pattern of cancer-specific metabolic changes remains unclear. Here we show, using comprehensive measurement enzymes by large-scale targeted proteomics, that both carbon and nitrogen altered during malignant progression cancer. The fate glutamine shifted from anaplerotic pathway into TCA cycle to nucleotide biosynthesis, with this shift being controlled glutaminase (GLS1) phosphoribosyl pyrophosphate amidotransferase (PPAT)....
Although the relationship between grassland productivity and soil water status has been extensively researched, responses of plant growth photosynthetic physiological processes to long-term drought rewatering are not fully understood. Here, perennial grass (Leymus chinensis), predominantly distributed in Euro-Asia steppe, was used as an experimental for irrigation manipulation experiment involving five moisture levels [75–80, 60–75, 50–60, 35–50, 25–35% relative content (SRWC), i.e. ratio...
The chloroplast NAD(P)H dehydrogenase (NDH) complex is involved in photosystem I (PSI) cyclic and chlororespiratory electron transport higher plants. Although biochemical genetic evidence for its subunit composition has accumulated, it not enough to explain the complexes putative activity of NAD(P)H-dependent plastoquinone reduction. We analyzed NDH by using blue native PAGE found that interacts with PSI form a novel supercomplex. Mutants lacking NdhL NdhM accumulated pigment-protein...
Two isomers of a multifunctional π-expanded macrocyclic oligothiophene 8-mer, E,E-1 and Z,Z-1, were synthesized using McMurry coupling dialdehyde composed four 2,5-thienylene three ethynylene units under high dilution conditions. On the other hand, cyclo[8](2,5-thienylene-ethynylene) 2 was by intramolecular Sonogashira cyclization ethynyl bromide 5. From STM measurements, both Z,Z-1 formed self-assembled monolayers at solid-liquid interface to produce porous networks, from X-ray analyses 2,...
BackgroundAlthough many prognosis-predicting molecular scores for breast cancer have been developed, they are applicable to only limited disease subtypes. We aimed develop a novel prognostic score that is wider range of patients.MethodsWe initially examined The Cancer Genome Atlas cohort identify potential prognosis-related genes. then performed meta-analysis 36 international cohorts validate such trained artificial intelligence models (random forest and neural network) predict prognosis...
Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3%) is a recently described marker hepatocellular carcinoma (HCC), and its usefulness has been demonstrated in many studies. We evaluated the serial measurement AFP-L3% as prognosis recurrence after treatment small HCC.AFP-L3% was measured before initial 60 patients with HCC (maximum diameter < or = 2 cm). taken ratio AFP-L3 to total AFP multiplied by 100%, levels > 10% were considered positive. Outcomes compared between...
The chloroplast NAD(P)H dehydrogenase (NDH) complex functions in PSI cyclic and chlororespiratory electron transport higher plants. Eleven plastid-encoded three nuclear-encoded subunits have been identified so far, but the entire subunit composition, especially of putative donor-binding module, is unclear. We isolated Arabidopsis thaliana crr23 (chlororespiratory reduction) mutants lacking NDH activity according to absence a transient increase Chl fluorescence after actinic light...
Multifunctional π-expanded macrocyclic oligothiophene 6-mer 1, as well 9- (2) and 12-mers (3), was synthesized using a McMurry coupling reaction the key step. The 1 converted to cyclo[6](2,5-thienylene-ethynylene) (4) by bromination-dehydrobromination procedure. From X-ray analysis, crystal structures of nonplanar round-shaped 2 4 were elucidated. STM showed that formed self-assembled monolayer at liquid/solid interface produce hexagonal porous network. Chemical oxidation 2, with equiv...
Hepatic iron overload is a risk factor for progression of hepatocellular carcinoma (HCC), although the molecular mechanisms underlying this association have remained unclear. We now show that iron-sensing ubiquitin ligase FBXL5 previously unrecognized oncosuppressor in liver carcinogenesis mice. Hepatocellular elicited by ablation gave rise to oxidative stress, tissue damage, inflammation, and compensatory proliferation hepatocytes consequent promotion induced exposure chemical carcinogen....
Abstract Although several long noncoding RNAs (lncRNAs) have recently been shown to encode small polypeptides, those in testis remain largely uncharacterized. Here we identify two sperm-specific Kastor and Polluks, encoded by a single mouse locus ( Gm9999 ) previously annotated as encoding lncRNA. Both Polluks are inserted the outer mitochondrial membrane directly interact with voltage-dependent anion channel (VDAC), despite their different amino acid sequences. Male VDAC3-deficient mice...