A5015523345- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- Phagocytosis and Immune Regulation
- Tissue Engineering and Regenerative Medicine
- Tryptophan and brain disorders
- Multiple Myeloma Research and Treatments
- Inflammatory mediators and NSAID effects
- Hematopoietic Stem Cell Transplantation
- Viral-associated cancers and disorders
- Nanoplatforms for cancer theranostics
- Intensive Care Unit Cognitive Disorders
- Galectins and Cancer Biology
- Organic Chemistry Cycloaddition Reactions
- Respiratory Support and Mechanisms
- RNA Interference and Gene Delivery
Établissement Français du Sang
2016-2025
Inserm
2016-2025
Université de Rennes
2016-2025
Centre Hospitalier Universitaire de Rennes
2016-2025
Université Rennes 2
2014-2024
La Ligue Contre le Cancer
2013-2023
Structure Fédérative de Recherche en Biologie et Santé de Rennes
2014-2023
Immunité et Cancer
2022-2023
Microenvironment and B-cells: Immunopathology, Cell, Differentiation and Cancer
2022
Laboratoire des Sciences de l’Information et de la Communication
2022
A subset of cancer-associated fibroblasts (FAP+/CAF-S1) mediates immunosuppression in breast cancers, but its heterogeneity and impact on immunotherapy response remain unknown. Here, we identify 8 CAF-S1 clusters by analyzing more than 19,000 single from cancer. We validate the five most abundant flow cytometry silico analyses other cancer types, highlighting their relevance. Myofibroblasts 0 3, characterized extracellular matrix proteins TGFβ signaling, respectively, are indicative primary...
Sepsis induces a sustained immune dysfunction responsible for poor outcome and nosocomial infections. Myeloid-derived suppressor cells (MDSCs) described in cancer inflammatory processes may be involved sepsis-induced suppression, but their clinical impact remains poorly defined.To clarify phenotype, suppressive activity, origin, of MDSCs patients with sepsis.Peripheral blood transcriptomic analysis was performed on 29 sepsis 15 healthy donors. A second cohort 94 consecutive sepsis, 11...
Exaggerated release of neutrophil extracellular traps (NETs) along with decreased NET clearance and inability to remove apoptotic cells (efferocytosis) may contribute sustained inflammation in acute respiratory distress syndrome (ARDS). Recent studies experimental models ARDS have revealed the crosstalk between AMP-activated protein kinase (AMPK) high-mobility group box 1 (HMGB1), which effectiveness efferocytosis, thereby reducing severity.We investigated by macrophages from control...
Significance TLS, which are clusters of lymphocytes and stromal cells observed at sites chronic inflammation, play a key role in sustaining disease progression autoimmune conditions. While the these structures has been studied extensively, fibroblasts, nonhematopoietic cells, formation maintenance TLS not demonstrated. Here, we establish that, establishment, resident fibroblasts expand acquire immunological features process that is dependent on IL13 IL22. Interference with this or depletion...
Abstract Axicabtagene ciloleucel (axi-cel) demonstrated superior efficacy compared to standard of care as second-line therapy in patients with high-risk relapsed/refractory (R/R) large B cell lymphoma (LBCL) considered eligible for autologous stem transplantation (ASCT); however, clinical practice, roughly half R/R LBCL are deemed unsuitable candidates ASCT. The axi-cel remains be ascertained transplant-ineligible patients. ALYCANTE, an open-label, phase 2 study, evaluated a 62 who were...
Autoimmune diseases (ADs) are characterized by loss of immune tolerance, high chronicity, with substantial morbidity and mortality, despite conventional immunosuppression (IS) or targeted disease modifying therapies (DMTs), which usually require repeated administration. Recently, novel cellular (CT), including mesenchymal stromal cells (MSC), Chimeric Antigen Receptors T (CART) regulatory (Tregs), have been successfully adopted in ADs. An international expert panel the European Society for...
Clinical-grade mesenchymal stromal cells (MSCs) are usually expanded from bone marrow (BMMSCs) or adipose tissue (ADSCs) using processes mainly differing in the use of fetal calf serum (FCS) human platelet lysate (PL). We aimed to compare immune modulatory properties clinical-grade MSCs a combination fully standardized vitro assays. BMMSCs with FCS (BMMSC-FCS) PL (BMMSC-PL), and ADSC-PL were analyzed quantitative phenotypic functional experiments, including their capacity inhibit...
The early steps of differentiation human B cells into plasma are poorly known. We report a transitional population CD20(low/-)CD38(-) preplasmablasts along memory in vitro. Preplasmablasts lack documented cell or (CD20, CD38, and CD138) markers, express CD30 IL-6R, secrete Igs at weaker level than do plasmablasts cells. These further differentiate CD20(-)CD38(high)CD138(-) then CD20(-)CD38(high)CD138(+) were fully characterized terms whole genome transcriptome profiling phenotype. coexpress...
DNA microarrays have considerably helped to improve the understanding of biological processes and diseases. Large amounts publicly available microarray data are accumulating, but poorly exploited due a lack easy-to-use bioinformatics resources. The aim this study is build free convenient data-mining web site (www.genomicscape.com). GenomicScape allows mining dataset from various platforms, identifying genes differentially expressed between populations, clustering visualizing expression...