A5031860797- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Chronic Lymphocytic Leukemia Research
- Autoimmune and Inflammatory Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Biosimilars and Bioanalytical Methods
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- NF-κB Signaling Pathways
- Digestive system and related health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- COVID-19 Clinical Research Studies
- Cancer Cells and Metastasis
- Systemic Sclerosis and Related Diseases
- Tuberculosis Research and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis C virus research
- Lymphoma Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Cytokine Signaling Pathways and Interactions
- IgG4-Related and Inflammatory Diseases
- Pluripotent Stem Cells Research
- Renal Diseases and Glomerulopathies
- Immune Cell Function and Interaction
Osaka University
2020-2025
Osaka University Hospital
2025
Osaka Minami Medical Center
2016-2022
Kyushu University
2011-2022
Osaka International University
2022
Japan Science and Technology Agency
2011-2012
The causality and pathogenic mechanism of microbiome composition remain elusive in many diseases, including autoimmune diseases such as rheumatoid arthritis (RA). This study aimed to elucidate gut microbiome's role RA pathology by a comprehensive metagenome-wide association (MWAS).We conducted MWAS the Japanese population (ncase=82, ncontrol=42) using whole-genome shotgun sequencing high depth (average 13 Gb per sample). Our consisted three major bioinformatic analytic pipelines...
Consecutive mRNA vaccinations against SARS-CoV-2 reinforced both innate and adaptive immune responses. However, it remains unclear whether the enhanced responses are mediated by epigenetic regulation and, if so, these effects persist. Using mass cytometry, RNA-Seq, ATAC-Seq, we show that BNT162b2 vaccination upregulated antiviral IFN-stimulated gene expression in monocytes with greater after second than those first vaccination. Transcription factor-binding motif analysis also revealed...
Abstract This multi-center, retrospective study aimed to clarify the factors affecting drug retention of Janus kinase inhibitors (JAKi) including baricitinib (BAR) and tofacitinib (TOF) in patients with RA. Patients were as follows; females, 80.6%; age, 60.5 years; DAS28-ESR, 4.3; treated either BAR (n = 166) or TOF 185); bDMARDs- JAKi-switched cases (76.6%). The reasons for discontinuation classified into four major categories. was evaluated at 24 months using Kaplan–Meier method...
Abstract Although the mammalian intestinal epithelium manifests robust regenerative capacity after various cytotoxic injuries, underlying mechanism has remained unclear. Here we identify cyclin-dependent kinase inhibitor p57 as a specific marker for quiescent cell population located around +4 position of crypts. Lineage tracing reveals that + cells serve enteroendocrine/tuft precursors under normal conditions but dedifferentiate and act facultative stem to support regeneration injury....
This multicentre retrospective study in Japan aimed to assess the retention of biological disease-modifying antirheumatic drugs and Janus kinase inhibitors (JAKi), clarify factors affecting their a real-world cohort patients with rheumatoid arthritis.The included 6666 treatment courses (bDMARD-naïve or JAKi-naïve cases, 55.4%; tumour necrosis factor (TNFi) = 3577; anti-interleukin-6 receptor antibodies (aIL-6R) 1497; cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA4-Ig) 1139; JAKi=453...
Peripheral neuropathy is a complication in systemic sclerosis that occasionally encountered clinical settings. The mechanisms underlying this condition remain unclear and treatment strategies have not yet been established, making management challenging. Here, we report case of peripheral associated with was successfully treated corticosteroid therapy despite the absence conventional inflammatory findings on histopathology or blood tests. A 44-year-old Japanese man diagnosed presented...
ABSTRACT Objective We aimed to identify the impact of rheumatoid factor (RF) or anti-cyclic citrullinated peptide antibody (ACPA) titers on retention biological disease-modifying antirheumatic drugs (bDMARDs) and Janus kinase inhibitors (JAKi) in patients with arthritis. Methods retrospectively analyzed 5312 courses bDMARDs JAKi from ANSWER cohort. To calculate hazard ratios (HRs) for treatment discontinuation, we used multivariate Cox proportional hazards modeling, adjusted potential...
Abstract Objectives This multicentre retrospective study aimed to evaluate differences in drug continuation rates and efficacy between first- second-line use of biological disease-modifying antirheumatic drugs (bDMARDs) Janus kinase inhibitors (JAKi) after failure the initial therapy real-world rheumatoid arthritis (RA) settings. Methods Data from an observational registry patients with RA Japan were analysed, encompassing 5,900 treatment courses (4,046 bDMARD/JAKi-naïve cases 1,854 s-line...
Undifferentiated arthritis (UA) often develops into rheumatoid (RA), but predicting disease progression from seronegative UA remains challenging because RA does not meet the classification criteria. This study aims to build a machine learning (ML) model predict using clinical and laboratory parameters. KURAMA cohort (training dataset) ANSWER (validation were utilized. Patients with selected based on specific inclusion exclusion Clinical parameters, including demographic data, acute phase...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to severe disease 2019 (COVID-19), which is characterized by cytokine storm and organ dysfunction. The spike S1 subunit induces inflammatory production, but the immune cell subsets that respond stimulation contribute severity remain unclear. Methods We analyzed serum samples peripheral blood mononuclear cells (PBMCs) from patients with COVID-19 (moderate: n = 7; severe: 25) healthy controls (...
Oxidative stress has been implicated in cancer initiation and progression. Fbxw7 (also known as Fbw7, SEL-10, hCdc4, or hAgo) is the F-box protein subunit of an Skp1-Cul1-F-box (SCF)-type ubiquitin ligase complex that plays a central role degradation oncoproteins such c-Myc, c-Jun, Notch, cyclin E. therefore thought to function tumor suppressor, indeed gene frequently mutated many human malignancies. The locus encodes three isoforms: Fbxw7α, Fbxw7β, Fbxw7γ. Whereas Fbxw7α Fbxw7γ are resident...
Abstract Objectives The impact of individual biological/targeted synthetic DMARD (b/tsDMARD) on kidney function in patients with RA remains unclear. This study aimed to determine the comparative effects b/tsDMARDs chronic disease (CKD) incidence RA. Methods multicentre cohort included who had baseline estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 and started a TNF inhibitor (TNFi), cytotoxic T-lymphocyte-associated antigen-4-Ig (CTLA4-Ig), interleukin-6 receptor inhibitor,...
A 26-year-old woman with Takayasu's arteritis (TAK) experienced back and neck pain during tocilizumab (TCZ) treatment. The levels of C-reactive protein were normal, ultrasonography revealed no significant changes. Diffusion-weighted whole-body imaging background body signal suppression (DWIBS) showed enhancement in the walls several arteries. Contrast computed tomography arterial inflammation same lesion. After increasing dose prednisolone TCZ, all enhancements decreased continued to...
ABSTRACT A 26-year-old woman with tuberous sclerosis complex (TSC) received outpatient treatment for the complication of systemic lupus erythematosus (SLE) at our hospital. She visited hospital a chief complaint pitting oedema in bilateral lower legs 3 days. The urinalysis showed massive proteinuria lot white blood cell casts. tests revealed hypoalbuminaemia, hypercholesterolaemia, hypocomplementaemia, and elevated anti-double-stranded DNA antibody titre. Renal biopsy was not performed...
Abstract Background This work aims to develop a deep learning model, assessing atlantoaxial subluxation (AAS) in rheumatoid arthritis (RA), which can often be ambiguous clinical practice. Methods We collected 4691 X-ray images of the cervical spine 906 patients with RA. Among these images, 3480 were used for training 803 validating model during process, and remaining 408 testing performance trained model. The two-dimensional key points’ detection Deep High-Resolution Representation Learning...
To investigate if disease activity among elderly RA patients >75 years of age has changed over time in the real-world clinical setting.
Abstract Anti-neutrophil cytoplasmic Ab (ANCA)–associated vasculitis (AAV) is a life-threatening condition characterized by improper activation of neutrophils and the release neutrophil extracellular traps (NETs) in small vessels. This study aimed to explain role NETs AAV pathogenesis investigating link between adhesion NET using human neutrophils. We leveraged an imaging flow cytometry–based assay three-dimensional culture demonstrate that essential for ANCA-induced formation. confirmed...
Autoimmune inflammatory rheumatic disease (AIRD) patients are at high risk of the coronavirus 2019 (COVID-19), but medium-term effects immunosuppressants on vaccine efficacy unknown. We investigated duration humoral responses against severe acute respiratory syndrome 2 (SARS-CoV-2) wild-type and Omicron variant in AIRD administered with two doses BNT162b2 (Pfizer-BioNTech) vaccine.Serum-neutralizing antibody (NAb) anti-receptor-binding domain (RBD)/spike levels were measured. Short- analyzed...
Infection is a serious complication observed in the management of rheumatoid arthritis (RA) patients. The acute inflammatory marker C-reactive protein (CRP) elevated both during infection and high disease activity RA, this often poses problem when distinguishing two. While markers should be measured quickly inexpensively simple matter, there also need to distinguish them from RA clinical practice. Recently, usefulness subtype soluble CD14, presepsin (P-SEP), has been reported critical care...
Induced pluripotent stem cells (iPSCs) share many biological properties with embryonic (ESCs), and are generated from somatic by expression of some transcription factors such as Oct3/4, Sox2, Klf4 c-Myc. Among these factors, the abundance c-Myc is strictly regulated Fbxw7, a subunit Skp1-Cul1-F-box protein-type ubiquitin ligase. We have now shown that Fbxw7 was increased ESCs differentiated. To investigate role in ESCs/iPSCs, we examined impact ablation efficiency iPSC generation. The...
A 72-year-old man presented with persistent oligoarthritis and positive results for rheumatoid factor was suspected of having arthritis (RA). However, the musculoskeletal ultrasonography (MSUS) findings were not consistent those typical RA. He had undergone surgery carpal tunnel syndrome, which allowed both histopathological microbiological examinations to be performed. synovial tissue culture Sporothrix schenckii, he diagnosed sporotrichal tenosynovitis. received anti-fungal therapy,...