A5080036669- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Vasculitis and related conditions
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Sarcoidosis and Beryllium Toxicity Research
- Thyroid Disorders and Treatments
- Peptidase Inhibition and Analysis
- Autoimmune and Inflammatory Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- Skin Diseases and Diabetes
- Otitis Media and Relapsing Polychondritis
- Urticaria and Related Conditions
- Chronic Lymphocytic Leukemia Research
- Mesenchymal stem cell research
- Medical Imaging and Pathology Studies
- Immunodeficiency and Autoimmune Disorders
- Pregnancy and Medication Impact
- T-cell and B-cell Immunology
- Neuroendocrine Tumor Research Advances
- Dermatologic Treatments and Research
- Platelet Disorders and Treatments
- Lymphoma Diagnosis and Treatment
Osaka University of Pharmaceutical Sciences
2021-2025
Center for Rheumatology
2022
Osaka Medical and Pharmaceutical University
2012-2021
Yodogawa Christian Hospital
2014
Osaka Ohtani University
2006
University of Miyazaki
1985-2002
Miyazaki Welfare Medical College
1992-1998
Hokkaido University
1985-1989
Sapporo City General Hospital
1982
Two forms of human thyroid peroxidase cDNAs were isolated from a lambda gt11 cDNA library, prepared Graves disease tissue mRNA, by use oligonucleotides. The longest complete cDNA, designated phTPO-1, has 3048 nucleotides and an open reading frame consisting 933 amino acids, which would encode protein with molecular weight 103,026. Five potential asparagine-linked glycosylation sites are found in the deduced acid sequence. second phTPO-2, is almost identical to phTPO-1 beginning 605 base...
We retrospectively investigated clinical prognostic factors for interstitial pneumonia (IP) in anti-melanoma differentiation-associated gene 5 (MDA5) antibody (Ab)-positive dermatomyositis (DM) patients.Subjects comprised 18 patients with anti-MDA5 Ab-positive DM-IP (9 survivors; 9 deaths).Initial serum albumin levels, ferritin and ground-glass opacity (GGO) scores the right middle lobes were significantly higher death group than survivor (p = .033, .013, .005, respectively). Initial...
Adipose-derived stem cells (AdSCs) have recently been considered a useful treatment tool for autoimmune disease because of their anti-inflammatory and immunosuppressive effects. We investigated the therapeutic effect intravenous AdSC transplantation in mouse model bleomycin-induced lung injury. AdSCs accumulated pulmonary interstitium inhibited both inflammation fibrosis lung, markedly improving survival rate mice with injury cell number-dependent manner. production pro-inflammatory...
To clarify whether apoptosis of thyroid follicular epithelial cells occurs at the tissue level in autoimmune thyroiditis, 17 specimens tissues with Hashimoto's thyroiditis were stained for fragmented DNA. Almost all nuclei forming atrophic follicles surrounded by mononuclear cell infiltration and fibrosis showed positive staining. With increasing distance from lymphoid follicles, percentage DNA fragmentation-positive decreased (30-80%). Electron microscopic study revealed existence shrunk...
It is difficult to differentiate polymyalgia rheumatica (PMR) from elderly-onset rheumatoid arthritis (EORA) in clinical practice. We compared FDG-PET/CT findings between patients with PMR and those EORA extracted factors useful for differentiating the two disorders.We abnormal FDG accumulation sites maximum standardized uptake value (SUVmax) 15 7 whom was performed.The proportion of group at following 9 on significantly higher than that group: periarticular region scapulohumeral joint,...
SUMMARY Thyroid peroxidase purified from porcine thyroid (pTPO) was found to induce an experimental murine thyroiditis with genetic restriction which very different that induced by mouse thyroglobulin (mTg). C57BL/6 and C57BL/10 (both H-2b) were good responders for thyroiditis, whereas A/J (H.2a), BALB/c (H-2d), DBA/2 CBA (H-2k), C3H/He SJL/J (H-2s) poor responders. Genetic analyses using congenic or recombinant strains revealed the following results: The H-2-linked gene (probably I-A...
Acute/subacute interstitial pneumonia in dermatomyositis (DM-A/SIP) is a disease associated with poor prognosis that resists treatment glucocorticosteroids (GC) and progresses rapidly period of weeks to months death. We retrospectively studied outcomes, prognostic factors, their relations survival rate patients DM-A/SIP treated early cyclosporine A (CSA)/GC combination therapy 2-hour postdose blood concentration monitoring.This study comprised 32 who were simultaneously CSA prednisolone....
Abstract Objectives To elucidate the serum cytokine profile and address pathomechanism of interstitial lung disease (ILD) complicated with PM/DM. Methods Forty patients PM/DM-ILD were enrolled, principal components analysis cluster performed to classify into subgroups. Additionally, we compared profiles between survivors dead anti-melanoma differentiation-associated gene 5 antibody- anti-aminoacyl tRNA synthetase antibody-positive ILD patients. We also examined association various cytokines...
Abstract Objectives Anaemia, a common comorbidity of RA, is related to high disease activity and poor prognosis. It unknown which biologic/targeted synthetic (b/ts)-DMARDs are optimal for patients with anaemia RA in regulating controlling activity. Methods We investigated the change haemoglobin (Hb) levels, drug retention rates activities after administration b/ts-DMARDs different modes action [TNF inhibitors (TNFis), immunoglobulin fused cytotoxic T-lymphocyte antigen (CTLA-4-Ig), IL-6...
ABSTRACT Objectives To determine the current retention rate of mepolizumab (MPZ) and identify factors associated with drug in patients eosinophilic granulomatosis polyangiitis (EGPA) Kansai multicentre cohort (REVEAL cohort). Methods Sixty diagnosed EGPA treated MPZ between December 2016 June 2023 were enrolled. The clinical characteristics, including laboratory data, treatments administered, disease course outcomes, collected retrospectively. stratified into continuation (n = 53)...
Introduction This study aimed to identify new clinical phenotypes of microscopic polyangiitis (MPA) using a principal components analysis (PCA)-based cluster analysis. Methods A total 189 patients with MPA between May 2005 and December 2021 were enrolled from multicenter cohort in Japan (REVEAL cohort). Categorical PCA performed based on clinical, laboratory, radiological findings. Clinical characteristics outcomes, including all-cause mortality, respiratory-related end-stage renal disease...
Abstract Objectives This multicentre retrospective study aimed to evaluate differences in drug continuation rates and efficacy between first- second-line use of biological disease-modifying antirheumatic drugs (bDMARDs) Janus kinase inhibitors (JAKi) after failure the initial therapy real-world rheumatoid arthritis (RA) settings. Methods Data from an observational registry patients with RA Japan were analysed, encompassing 5,900 treatment courses (4,046 bDMARD/JAKi-naïve cases 1,854 s-line...
Unlike lactoperoxidase and horseradish peroxidase, thyroid peroxidase catalyzed the oxidation of hydroquinone mostly by way 2-electron transfer.This conclusion could be derived from three independent experiments: ESR measurements p-benzosemiquinone, trapping unpaired electron cytochrome e, spectrophotometric analysis catalytic intermediates enzymes.The 1-electron flux for was found to 15-19% in reaction while it nearly 100% reactions peroxidase.From enzyme, suggested that mechanism changes a...
Background Rheumatoid arthritis (RA) is the most common inflammatory joint disease. The aetiology of RA remains unknown, but autoimmune responses are considered to play an important role in disease pathophysiology. Currently available data suggests that process diagnosing may benefit from testing for anticyclic citrullinated peptides. Identification presence proteins rheumatoid synovial fluids elucidation as well differential diagnosis rheumatic-related diseases. Methods A proteomics-based...
Abstract Background This multi-center, retrospective study aimed to clarify retention rates and reasons for discontinuation of either tumor necrosis factor inhibitors (TNFi) or interleukin-6 (IL-6i) in patients with elderly-onset rheumatoid arthritis (EORA). Methods Patients (RA) enrolled a Japanese multicenter observational registry between 2011 2020 were included. EORA was defined as RA onset at 60 over. To adjust confounding by indication treatment TNFi IL-6i, propensity score based on...
Microscopic polyangiitis (MPA) is often complicated by interstitial lung disease (ILD); however, biomarkers that can be used to diagnose and predict the progression of MPA-ILD have not been identified. In this study, we evaluated various serum in assess their diagnostic predictive performance.We enrolled 49 patients with anti-neutrophil cytoplasmic antibody (ANCA)+ MPA 10 healthy controls, 32 also presenting ILD. The presence ILD was assessed high-resolution CT ground-glass opacity fibrosis...
In this study we describe a novel mutation of the thyroid peroxidase (TPO) gene that resulted in total iodide organification defect. TPO activity and thyroxine formation thyroglobulin gland patient were below limits detection. However, mRNA was detectable at similar size concentration as compared with normal tissues when measured by Northern blot analysis. Sequence analysis showed presence two mutations, missense exon 7 C insertion 14. These mutations heterozygous located different alleles....
OBJECTIVE: Thyroid peroxidase (TPO) deficiency is one of the causes thyroid dyshormonogenesis, because TPO plays a key role in hormone biosynthesis. To determine frequency and pattern abnormalities, we have been screening genes patients with congenital goitrous hypothyroidism. SUBJECTS AND METHODS: patient hypothyroidism her parents were directly sequenced, two novel missense mutations (R665W G771R) found. The former was derived from father latter mother. R665 G771 well conserved...
Chemokines play an important role in the pathophysiology of dermatomyositis (DM) with interstitial pneumonia (IP). However, relation between chemokines and disease activity or prognosis DM-IP has not been elucidated. We evaluated serum C-C motif chemokine ligand (CCL) 2, Th1 (C-X-C [CXCL] 9, CXCL10, CXCL11), Th2 (CCL17) profiles 30 patients, examined these DM-IP. Initial CCL2 level was higher death group (P = 0.007). To determine cut-off points effective as poor prognostic factors DM-IP, ROC...
We investigated the efficacy and safety of tacrolimus (TAC) by monitoring its serum concentration for mothers infants in pregnant patients with systemic lupus erythematosus (SLE).We measured trough concentrations TAC 25 SLE to assess influence on disease activity. Additionally, we umbilical arterial blood, breast milk, breastfed investigate infants.The significantly decreased second trimester as compared those before pregnancy. However, decrease did not lead deterioration SLE. When examined,...