A5038223019- Mast cells and histamine
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renin-Angiotensin System Studies
- Polyamine Metabolism and Applications
- Receptor Mechanisms and Signaling
- Hormonal Regulation and Hypertension
- Chemical Synthesis and Analysis
- Nitric Oxide and Endothelin Effects
- Asthma and respiratory diseases
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Ocular Surface and Contact Lens
- Urticaria and Related Conditions
- Intestinal and Peritoneal Adhesions
- Retinal Development and Disorders
- Food Allergy and Anaphylaxis Research
- Eicosanoids and Hypertension Pharmacology
- Retinal and Macular Surgery
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Surgical Sutures and Adhesives
- melanin and skin pigmentation
- Aortic aneurysm repair treatments
- Retinal and Optic Conditions
Osaka University of Pharmaceutical Sciences
1999-2025
Osaka Medical and Pharmaceutical University
2013-2023
Uppsala University
2020
Université de Sherbrooke
2013-2020
Swedish University of Agricultural Sciences
2013
Brigham and Women's Hospital
2013
Harvard University
2013
Weatherford College
2011
Kyoto Prefectural University of Medicine
2005
Hyogo Medical University
2005
Increased production of reactive oxygen species (ROSs) by angiotensin II (Ang II) is involved in the initiation and progression cardiovascular diseases. NADPH oxidase a major source superoxide generated vascular tissues. Although Nox1 has been identified smooth muscle cells as new homolog gp91phox (Nox2), catalytic subunit oxidase, pathophysiological function Nox1-derived ROSs not fully elucidated. To clarify role Ang II-mediated hypertension, we Nox1-deficient (-/Y) mice.No difference...
Abstract Objective Interleukin‐1β (IL‐1β) is a key cytokine linked to the pathogenesis of acute arthritis. Caspase 1, neutrophil elastase, and chymase all process proIL‐1β its biologically active form. This study was undertaken examine potential contributions each these proteases in experimental models inflammatory Methods 1–deficient ( Casp1 −/− ) wild‐type (WT) mice were tested for their response arthritogenic K/BxN serum transfer induction arthritis or injection monosodium urate...
Recently, aldosterone has been shown to activate local renin-angiotensin system in vitro. To elucidate the potential role of aldosterone-induced cardiovascular injury, we investigated effects selective mineralocorticoid receptor (MR) antagonist eplerenone (EPL), angiotensin (Ang) II type 1 candesartan (ARB), and superoxide dismutase mimetic tempol (TEM) on development hypertension, vascular oxidative stress, inflammatory-related gene expression aldosterone-treated hypertensive rats. The...
Some reports have suggested that, in vitro, human heart chymase homogenates contributes little to angiotensin (Ang) II formation the presence of natural protease inhibitors such as alpha-antitrypsin. We studied whether bound heparin, resembling an vivo form, could contribute Ang inhibitors.The was increased time-dependently after incubation extract (1 mg protein/mL) vascular tissues containing I. The concentration for 30 minutes 1.67+/-0.06 nmol/mL, and we regarded this quantity 100%....
Aldosterone may be involved in the pathogenesis of atherosclerosis. We investigated effect eplerenone, a selective mineralocorticoid receptor blocker, on atherosclerosis monkeys fed high-cholesterol diet. Monkeys diet for 9 months were divided into 3 groups: those treated with low dose eplerenone (30 mg/kg per day); high (60 and placebo-treated group. The normal group consisted There no significant differences blood pressure cholesterol levels between placebo- eplerenone-treated groups. On...
1. We investigated the relationship between angiotensin II formation and development of atherosclerotic lesions in aorta monkeys (Macaca fascicularis) fed a high-cholesterol (4% cholesterol 6% corn oil) diet for 6 months, studied effects an converting enzyme (ACE) inhibitor, trandolapril (10 mg kg-1 per day, p.o.), type 1 receptor antagonist, 2-butyl-4-(methylthio)-1-[[2'[[[(propylamino)carbonyl]amino]sulfonyl] (1,1'-biphenyl)-4-yl]methyl]-1H-imidazole-5-carboxylate (HR 720; 20 p.o.). 2. The...
There are two types of human mast cells, tryptase-positive cells (MC(T)) and tryptase- chymase-positive (MC(TC)). Although MC(T) have been reported to be related the generation angiogenesis, little is known about involvement MC(TC) in tumor angiogenesis. In this study, clarify relationship between lung cancer we evaluated MC(TC), MC(T), microvessel counts normal, border, central regions.Tumor sections from 32 cases adenocarcinoma 13 squamous cell carcinoma were immunostained for chymase...
Background —Activation of vascular chymase plays a major role in myointimal hypertrophy after injury by augmenting the production angiotensin (ANG) II. Because is synthesized mainly mast cells, we assumed that chymase-dependent ANG II formation could be downregulated tranilast, cell–stabilizing antiallergic agent. We have assessed inhibitory effects tranilast on neointima balloon carotid artery dogs, which share similar II–forming with humans, and further explored pathophysiological...
Background Vascular tissues of humans and dogs contain chymase as an angiotensin II–forming enzyme. In this study, we investigated whether chymase-dependent II formation plays a crucial role in the development vascular proliferation dog grafted veins. Methods Results The right external jugular vein was to ipsilateral carotid artery. As control group, veins that had not received grafts were used. inhibitor–treated infiltrated with 10 μmol/L Suc-Val-Pro-Phe P (OPh) 2 placebo-treated ACE...
Chymase is expressed in mast cells and induces angiogenesis via activation of angiotensin II matrix metalloproteinase-9. However, it has been unclear whether chymase involved the pathophysiology gastric cancer. To clarify contribution to cancer, we assessed relationship between chymase-positive tumor angiogenesis.We evaluated microvessels using anti-human anti-CD34 antibodies 168 cases respectively.Chymase-positive region were significantly higher than normal region. The number...