A5068361428- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Imaging and Diagnostics
- Birth, Development, and Health
- Hormonal Regulation and Hypertension
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Coronary Interventions and Diagnostics
- Tryptophan and brain disorders
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- Fatty Acid Research and Health
- Aortic aneurysm repair treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipoproteins and Cardiovascular Health
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Cytokine Signaling Pathways and Interactions
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Mycobacterium research and diagnosis
Kumamoto University
2024
Kumamoto University Hospital
2024
Kyoto Prefectural University of Medicine
2013-2022
Suita Tokushukai Hospital
2021-2022
Kobe University
1989-2020
Tokyo University of Science
2018-2019
Kyoto Prefectural University
2006-2015
Kurashiki Central Hospital
2015
Center for Rheumatology
2013
National Center For Child Health and Development
2011-2012
Increased production of reactive oxygen species (ROSs) by angiotensin II (Ang II) is involved in the initiation and progression cardiovascular diseases. NADPH oxidase a major source superoxide generated vascular tissues. Although Nox1 has been identified smooth muscle cells as new homolog gp91phox (Nox2), catalytic subunit oxidase, pathophysiological function Nox1-derived ROSs not fully elucidated. To clarify role Ang II-mediated hypertension, we Nox1-deficient (-/Y) mice.No difference...
Medial artery calcification, which does not accompany lipid or cholesterol deposit, preferentially occurs in elderly population, but its underlying mechanisms remain unclear. In the present study, we investigated potential role of senescent vascular smooth muscle cells (VSMCs) formation senescence-associated medial calcification. Replicative senescence was induced by extended passages (until 11-13) human primary VSMCs, and early passage (passage 6) were used as control young cells. VSMC...
Vascular calcification is an important risk factor for cardiovascular diseases. Here, we investigated a role of dedifferentiated vascular smooth muscle cells (VSMCs) in the atherosclerotic intimal calcification.We prepared human cultured VSMCs either redifferentiatiated or state and analyzed gene expressions bone-calcification regulatory factors. Expression bone morphogenetic protein-2 (BMP-2), potent initiator osteoblast differentiation, was significantly enhanced VSMCs. Furthermore,...
Significance Caveolae are recognized as a platform for preassembled complexes of receptors, signal components, and their targets, facilitating efficient specific cellular responses at the plasma membrane. ERK is activated membrane an important molecule that has been well studied its integral role in transduction events during physiological adaptation pathological manifestation. Here we show although muscle-restricted coiled-coil protein (MURC)/Cavin-4, muscle-specific caveola component,...
Abstract Endovascular treatment (EVT) for patients with lower extremity artery disease is widely used as a less invasive alternative to surgical bypass. Recently, transradial intervention has gained popularity owing its minimally nature. The distance from the radial target vessel critical success; however, effective pre-assessment methods have not yet been established. This study aimed evaluate usefulness of predistance measurements left using simple computed tomography (CT) images. In this...
The angiotensin II (Ang II) type 1 (AT(1)) receptor is expressed in bone marrow (BM) cells, whereas it remains poorly defined how Ang regulates differentiation/proliferation of monocyte-lineage cells to exert proatherogenic actions.We generated BM chimeric apoE(-/-) mice repopulated with AT(1)-deficient (Agtr1(-/-)) or wild-type (Agtr1(+/+)) cells. atherosclerotic development was significantly reduced apoE(-/-)/BM-Agtr1(-/-) compared apoE(-/-)/BM-Agtr1(+/+) mice, accompanied by decreased...
Cardiorenal anemia syndrome has recently been receiving greater attention; however, data regarding the relationship between chronic kidney disease (CKD)/anemia on presentation and in-hospital outcome in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) are still limited Japan.A total of 1,447 PCI-treated AMI were classified into 4 groups according to presence CKD and/or hospital admission (with CKD/with n = 222, CKD/without 299,...
Endothelial and endothelial progenitor cells (ECs EPCs) play a fundamental role in angiogenesis that is essential for numerous physiological pathological processes. The phosphatase tensin homolog (PTEN)/ phosphoinositide 3-kinase (PI3K) pathway has been implicated angiogenesis, but the mechanism regulation of this ECs EPCs poorly understood. Here we show ARIA (apoptosis regulator through modulating IAP expression), transmembrane protein recently identified, regulates PTEN/PI3K controls...
Ageing is an important risk factor for ischemic cardiovascular diseases, although its underlying molecular mechanisms remain to be elucidated. Here, we report a crucial role of Bcl-2 in the impaired angiogenic functions senescent endothelial cells (ECs) by modulating mitochondrial redox state. Cellular senescence ECs without attenuating mitogen-activated protein kinase or Akt signaling, and vascular growth receptor 2 Tie-2 expressions. We identified that expression was markedly reduced 3...
Summary. The involvement of cyclic adenosine monophosphate (cAMP) in mammalian oocyte maturation was assessed using cultures rabbit cumulus–oocyte complexes and perfused ovaries. Rabbit were cultured Brackett's medium with or without forskolin at 10−4, 10−5 10−6 mol l−1 for 3–6 h. At 3 4 h spontaneous meiotic significantly (P < 0·05) inhibited by 10−4 l−1. With prolonged incubation, progressed despite exposure to forskolin. In the second experiment ovaries 12 (10−4, 10−6mol l−1) alone....
Background It remains uncertain whether obesity is an independent risk factor for coronary heart disease in young adults, as well Japan. Methods and Results In the present study, 1,260 cases of acute myocardial infarction (AMI) 3,775 community controls were recruited from AMI-Kyoto Multi-Center Risk Study Kyoto Citizen's Health Nutrition Study, respectively. Obesity other factors retrospectively examined between each subgroup males (20-40 years), middle-aged or females (40-60 older (60-80...
Reactive oxygen species (ROS) are involved in the initial process of atherosclerosis, whereas it remains to be determined how atherogenic stimulus causes ROS-mediated proinflammatory reactions. Here, we focused on proline-rich tyrosine kinase (PYK2)-mediated ROS generation and examined early reactions.PYK2-deficient (knockout [KO]) (PYK2-KO) mice were crossbred with apolipoprotein E (ApoE)-deficient (PYK2-KO/ApoE-KO) mice. PYK2-KO/ApoE-KO endothelial cells (EC) used for study. Aortic lesions...
Maternal obesity elicits offspring's metabolic disorders via developmental modifications of visceral adipose tissue; however, its effect on atherogenesis remains undefined. Perivascular tissue has recently been implicated in vascular remodeling and vasoreactivity. We hypothesize that perivascular by maternal high-fat diet (HFD) exposure promotes atherosclerosis adult offspring.Eight-week-old female apolipoprotein E-deficient mice were fed an HFD or normal (ND) during gestation lactation....
Atherosclerosis often advances before symptoms appear. It remains uncertain whether intensive cholesterol-lowering therapy with statin is beneficial when compared moderate in patients subclinical carotid atherosclerosis. The PEACE study was a prospective, randomized, open-labeled, blinded end points, two-arm parallel treatment group comparison conducted at 15 centers Japan. A total of 303 intima-media thickness (CIMT) thickening (>1.1 mm) whose low-density lipoprotein cholesterol (LDL-C)...
Chronic kidney disease (CKD) is an independent risk factor for the development of cardiovascular disease. The perivascular adipose tissue closely implicated in atherosclerosis; however, contribution to CKD-associated atherogenesis remains undefined. Eight-week-old apoE-deficient mice were uninephrectomized and fed a high-cholesterol diet starting at 12 wk age. atherosclerotic lesion area thoracic aorta was comparable 16-wk-old (UNX) sham control mice; markedly exaggerated 20-wk-old UNX...
Objective The predictors of in-hospital outcomes after primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) complicated with heart failure or cardiogenic shock at presentation remain unclear. Methods Using the AMI-Kyoto Multi-Center Risk Study database, clinical background characteristics, angiographic findings, PCI results, and prognoses were retrospectively compared between PCI-treated AMI patients a Killip class status ≥2 (Killip 2-4 patients, n=390)...