A5074970544- Atherosclerosis and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Angiogenesis and VEGF in Cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nitric Oxide and Endothelin Effects
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Hydrogen Storage and Materials
- Eicosanoids and Hypertension Pharmacology
- Immune cells in cancer
- Kawasaki Disease and Coronary Complications
- Venous Thromboembolism Diagnosis and Management
- Luminescence and Fluorescent Materials
- Cardiac Structural Anomalies and Repair
- Mesenchymal stem cell research
- Erythropoietin and Anemia Treatment
- Pulmonary Hypertension Research and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Molecular Sensors and Ion Detection
- Mineral Processing and Grinding
- Vascular Procedures and Complications
- Platelet Disorders and Treatments
- Coronary Artery Anomalies
- Cardiomyopathy and Myosin Studies
Saitama Prefectural Kasukabe Special Support School
2020
Toshiba (Japan)
2013-2015
Kyoto first Red Cross hospital
2010-2014
Kyoto Prefectural University of Medicine
2006-2011
Kansai Medical University
2006-2011
Keio University
2008-2011
Tottori University
2010
National Defense Medical College
2009
National Jewish Health
2009
University of Colorado Denver
2009
A new series of high-performance fluorophores named Keio Fluors (KFL), which are based on borondipyrromethene (BODIPY), reported. The KFL dyes cover a wide spectral range from the yellow (547 nm) to near-infrared (NIR, 738 region, and their emission wavelength could be easily subtly controlled simple molecular modifications only, without losing optical properties. This "tailor-made" synthetic strategy for tuning enabled creation fourteen with well-controlled colors (yellow, orange, red,...
We investigated whether the mobilization of endothelial progenitor cells (EPCs) by exogenous erythropoietin (Epo) promotes repair injured endothelium. Recombinant human Epo was injected (1000 IU/kg for initial 3 days) after wire injury femoral artery mice. Neointimal formation inhibited to 48% control (P<0.05) in an NO-dependent manner. induced a 1.4-fold increase reendothelialized area day 14 denuded vessels, 55% which derived from bone marrow (BM) cells. increased circulating...
Rationale : It has been reported that interleukin (IL)-1 is associated with pathological cardiac remodeling and LV dilatation, whereas IL-1β also shown to induce cardiomyocyte hypertrophy. Thus, the role of IL-1 in heart remains be determined. Objective We studied hypertrophy signal-mediated IL-1β/insulin-like growth factor (IGF)-1 production regulating progression from compensative pressure-mediated failure. Methods Results Pressure overload was performed by aortic banding IL-1β–deficient...
We report a novel near-infrared fluorescent calcium probe (KFCA), which has good optical properties such as intense NIR fluorescence emission (670 nm, QY: 0.24), excellent ON/OFF ratio (120-fold), and wavelength-compatibility with visible-light-emissive fluorophores (Fluo-4, DsRed2), is applicable for real-time dual-colour intracellular Ca2+ imaging.
Fulminant myocarditis presentation (FMP) is a rare and severe of myocarditis. The natural history FMP its clinical features associated with poor outcomes are incompletely understood because there lack generalizable evidence.This multicenter retrospective cohort study included patients hospitalized histologically proven who underwent catecholamine or mechanical support from 235 cardiovascular training hospitals across Japan between April 2012 March 2017. Clinical the prognostic predictors...
Background Transplantation of non-expanded peripheral blood mononuclear cells (PBMNCs) enhances neovessel formation in ischemic myocardium and limbs by releasing angiogenic factors. This study was designed to examine whether intracoronary transplantation PBMNCs improves cardiac function after acute myocardial infarction (AMI). Methods Results After successful percutaneous coronary intervention (PCI) for a ST-elevation AMI with occlusion proximal left anterior descending artery within 24 h,...
The angiotensin II (Ang II) type 1 (AT(1)) receptor is expressed in bone marrow (BM) cells, whereas it remains poorly defined how Ang regulates differentiation/proliferation of monocyte-lineage cells to exert proatherogenic actions.We generated BM chimeric apoE(-/-) mice repopulated with AT(1)-deficient (Agtr1(-/-)) or wild-type (Agtr1(+/+)) cells. atherosclerotic development was significantly reduced apoE(-/-)/BM-Agtr1(-/-) compared apoE(-/-)/BM-Agtr1(+/+) mice, accompanied by decreased...
Background— The involvement of Ca 2+ -dependent tyrosine kinase PYK2 in the Akt/endothelial NO synthase pathway remains to be determined. Methods and Results— Blood flow recovery neovessel formation after hind-limb ischemia were impaired −/− mice with reduced mobilization endothelial progenitors. Vascular growth factor (VEGF)–mediated cytoplasmic -independent Akt activation markedly decreased PYK2-deficient aortic cells, whereas AMP-activated protein kinase/protein kinase-A that...
Cardiorenal anemia syndrome has recently been receiving greater attention; however, data regarding the relationship between chronic kidney disease (CKD)/anemia on presentation and in-hospital outcome in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) are still limited Japan.A total of 1,447 PCI-treated AMI were classified into 4 groups according to presence CKD and/or hospital admission (with CKD/with n = 222, CKD/without 299,...
Reactive oxygen species (ROS) are involved in the initial process of atherosclerosis, whereas it remains to be determined how atherogenic stimulus causes ROS-mediated proinflammatory reactions. Here, we focused on proline-rich tyrosine kinase (PYK2)-mediated ROS generation and examined early reactions.PYK2-deficient (knockout [KO]) (PYK2-KO) mice were crossbred with apolipoprotein E (ApoE)-deficient (PYK2-KO/ApoE-KO) mice. PYK2-KO/ApoE-KO endothelial cells (EC) used for study. Aortic lesions...
Objective The predictors of in-hospital outcomes after primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) complicated with heart failure or cardiogenic shock at presentation remain unclear. Methods Using the AMI-Kyoto Multi-Center Risk Study database, clinical background characteristics, angiographic findings, PCI results, and prognoses were retrospectively compared between PCI-treated AMI patients a Killip class status ≥2 (Killip 2-4 patients, n=390)...
Members of the fibroblast growth factor (FGF) family have been clinically applied to treatment ischemic diseases because their strong angiogenic actions. Although tissue ischemia is predominantly caused by atherosclerosis, roles endothelial FGF receptors (FGF-Rs) in atherosclerosis remain obscure. We generated cell (EC)-targeted constitutively active FGF-R2-overexpressing mice, using Tie2 promoter (Tie2-FGF-R2-Tg), and crossed them with apolipoprotein E (ApoE)-deficient mice (ApoE-KO)...
Bone marrow (BM)-derived endothelial progenitor cells (EPCs) and vascular smooth muscle (VPCs) contribute to neointima formation, whereas the angiotensin II (Ang II) type 1 receptor (AT(1))-mediated action on BM-derived progenitors remains undefined.A wire-induced injury was performed in femoral artery of BM-chimeric mice whose BM repopulated with AT(1)-deficient (BM-Agtr1(-/-)) or wild-type (BM-Agtr1(+/+)) cells. Neointima formation profoundly reduced by 38% BM-Agtr1(-/-) mice. Although...
Background: Predictors of in-hospital outcome after primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) requiring mechanical support devices such as intra-aortic balloon pumping (IABP) and/or cardiopulmonary (PCPS) remain unclear. Methods and Results: Using the AMI-Kyoto Multi-Center Risk Study database, clinical background, angiographic findings, results PCI, prognosis were retrospectively compared between PCI-treated AMI patients assist (with-IABP/PCPS...
We report on a 10-year-old girl with anhidrosis and insensibility to pain, but no severe mental retardation or self-mutilation, diagnosed as hereditary sensory autonomic neuropathy type IV (HSAN IV). Genetic analysis of her TRKA gene, which is responsible for HSAN IV, revealed two novel missense mutations in the tyrosine kinase domain. Cardiovascular nervous system function tests showed normal muscle sympathetic nerve activity associated arterial baroreflex, reduced skin second fifth fingers...
We confirmed that the gas blowing condition during perovskite formation is suitable for fabricating large-scale cells composed of a PEDOT:PSS layer as scaffold. Gas minimized defects at interface between and created flat layer. The crystallization process by which grew was different from one-step spin-coating. led to with orientation along (310) plane.
(Echocardiography 2010;27:1291‐1295)