A5049596064- Signaling Pathways in Disease
- Pancreatic and Hepatic Oncology Research
- Receptor Mechanisms and Signaling
- Migraine and Headache Studies
- Bacterial Genetics and Biotechnology
- Glycosylation and Glycoproteins Research
- Neutropenia and Cancer Infections
- Economic and Financial Impacts of Cancer
- Trigeminal Neuralgia and Treatments
- Cancer Genomics and Diagnostics
- RNA and protein synthesis mechanisms
- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Autoimmune and Inflammatory Disorders Research
- Lung Cancer Research Studies
- Rheumatoid Arthritis Research and Therapies
- Parkinson's Disease Mechanisms and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Fibroblast Growth Factor Research
- Neurological disorders and treatments
- Enzyme Production and Characterization
- Psychosomatic Disorders and Their Treatments
- Pain Management and Opioid Use
Showa University
2010-2023
Showa University Hospital
2016-2020
Showa University Karasuyama Hospital
2020
American Pharmacists Association
2017
Osaka Medical and Pharmaceutical University
2007
Kobe University
2007
Kansai Medical University
2007
Suntory (Japan)
2006
Biomedical Research Laboratories (United States)
2006
Kyushu University
2006
Longitudinal bone growth is determined by endochondral ossification that occurs as chondrocytes in the cartilaginous plate undergo proliferation, hypertrophy, cell death, and osteoblastic replacement. The natriuretic peptide family consists of three structurally related endogenous ligands, atrial, brain, C-type peptides (ANP, BNP, CNP), thought to be involved a variety homeostatic processes. To investigate physiological significance CNP vivo , we generated mice with targeted disruption (...
Angiotensin (Ang) II has two major receptor isoforms, AT1 and AT2. Currently, antagonists are undergoing clinical trials in patients with cardiovascular diseases. Treatment causes elevation of plasma Ang which selectively binds to AT2 exerts as yet undefined effects. Cardiac level is low adult hearts, whereas its distribution ratio increased during cardiac remodeling action enhanced by application antagonists. Although knock-out mice sensitivity the pressor was increased, underlying...
Mitochondrial oxidative stress and damage play major roles in the development progression of left ventricular (LV) remodeling failure after myocardial infarction (MI). We hypothesized that overexpression mitochondrial antioxidant, peroxiredoxin-3 (Prx-3), could attenuate this deleterious process.We created MI 12- to 16-week-old, male Prx-3-transgenic mice (TG+MI, n=37) nontransgenic wild-type (WT+MI, n=39) by ligating coronary artery. Prx-3 protein levels were 1.8 times higher hearts from TG...
The aim of this study was to assess the acute effects clonazepam and clonidine on rhythmic masticatory muscle activity in young adults with primary sleep bruxism, as well accompanying architecture cardiac activity. This used a double-blind, crossover, placebo-controlled design. Polysomnography performed 19 subjects [nine men 10 women; mean age (±SE): 25.4 ± 2.7 years] for 5 nights. first 2 nights were habituation diagnosis bruxism. other 3 randomly assigned (1.0 mg), (0.15 mg) or placebo...
ARPP-16 (cAMP-regulated phosphoprotein of Mr = 16,000) is a substrate for cAMP-dependent protein kinase and enriched in the basal ganglia. has been purified to homogeneity from soluble fraction bovine caudate nuclei. An additional 19,000 (ARPP-19) was found cross-react with rabbit anti-serum prepared against ARPP-16. Immunological analysis indicated that ganglia while ARPP-19 present similar levels all brain regions studied also non-neuronal tissues. nucleus cytosol. Using oligonucleotide...
Background— The involvement of Ca 2+ -dependent tyrosine kinase PYK2 in the Akt/endothelial NO synthase pathway remains to be determined. Methods and Results— Blood flow recovery neovessel formation after hind-limb ischemia were impaired −/− mice with reduced mobilization endothelial progenitors. Vascular growth factor (VEGF)–mediated cytoplasmic -independent Akt activation markedly decreased PYK2-deficient aortic cells, whereas AMP-activated protein kinase/protein kinase-A that...
A cDNA clone for the mRNA of bovine DARPP-32 (dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein, Mr = 32,000) was isolated from a modified Okayama-Berg plasmid library. Transformed Escherichia coli colonies were screened by in situ colony hybridization with 2 different oligonucleotide probes corresponding to region unusually rich glutamate within protein. Three positive clones shown encode an immunoblot assay their fusion protein products beta-galactosidase. The results...
Sustained cardiac pressure overload induces mitochondrial dysfunction and apoptosis of cardiomyocytes leading to pathological hypertrophy dysfunction. Mitochondrial nitric oxide synthase (NOS) appears cause uncoupling, which produces reactive oxygen species (ROS) instead (NO), by a decrease in the cofactor tetrahydrobiopterin (BH4). This study focused on examining changes BH4 levels during overload. Chronic was generated abdominal aortic banding rats. Levels its oxidized form were measured...
Atomoxetine (ATX) is a non-central stimulant and standard treatment for adult attention-deficit/hyperactivity disorder (ADHD). The long-term efficacy of about 40% at 6 months. variability in between individuals thought to be related patient-specific factors, but no detailed research has been conducted. In this retrospective cohort study, we aimed identify the factors associated with efficacy.A total 147 patients aged ≥18 years who were using first time included study. outcome was success...
A new class of Escherichia coli mutants, referred to as grn, has been isolated by localized mutagenesis. These mutations affect the sigma subunit DNA-dependent RNA polymerase (ribonucleoside 5'-triphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) abolishing expression lambda N gene, and they are closely lniked dnaG in order dnaG-grn-uxaA. Detailed study one such mutant, grn1, yielded following results: (i) grn1 is a single mutation mutant cell shows cold-sensitivity growth; (ii) Grn...
Background and PurposezzValproate is used as a prophylactic drug for migraine, but it not be effective in all patients.We medical records to investigate which clinical factors affected the response valproate patients with migraine an original headache, established scoring system predicting therapy.MethodszzWe investigated from of 95 consistent responders (CRs) 24 inconsistent (IRs) valproate.ResultszzMultivariate stepwise logistic regression analysis revealed that history hyperlipidemia hay...
We conducted a historical cohort study of patients with schizophrenia to identify more robust risk factors at discharge that contribute readmission within year.The subjects underwent brief psychoeducation during hospitalization. Multivariate analysis was using selected in the univariate analysis. Using logistic regression analysis, number hospital admissions (P = .01) and Schedule for Assessment Insight Japanese version score .04) were identified as readmission, odds ratios 0.70 1.18,...
A new member of the serine protease inhibitor (serpin) superfamily with megakaryocyte maturation activity was purified, and its cDNA cloned characterized. The predicted amino acid sequence consisting 380 residues unique 38% identical to serpin plasminogen activator type 2 (PAI-2). recombinant factor expressed in Chinese hamster ovary cells showed species-specific on induction maturation<i>in vitro</i>. When injected into mice, indeed elicited an increase number platelets plasma. alignment...