A5010484118- Adrenal and Paraganglionic Tumors
- Sports Dynamics and Biomechanics
- Pancreatic function and diabetes
- Hormonal Regulation and Hypertension
- Liver Disease Diagnosis and Treatment
- Advancements in Solid Oxide Fuel Cells
- Regulation of Appetite and Obesity
- Adrenal Hormones and Disorders
- Fuel Cells and Related Materials
- Experimental and Theoretical Physics Studies
- Ear Surgery and Otitis Media
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Elasticity and Material Modeling
- Metabolism and Genetic Disorders
- Pituitary Gland Disorders and Treatments
- Catalysis and Oxidation Reactions
- Sports Analytics and Performance
- 3D Printing in Biomedical Research
- Diabetes and associated disorders
- Vestibular and auditory disorders
- Biochemical Analysis and Sensing Techniques
- Cellular Mechanics and Interactions
- Fibroblast Growth Factor Research
Kyushu University
2020-2024
Kyoto University
2002-2021
Nishogakusha University
2018-2021
Aoyama Gakuin University
2020-2021
Kyushu University Hospital
2021
Waseda University
2009-2019
Mitsubishi Materials (Japan)
2004-2016
Air Water (Japan)
2014
National Cerebral and Cardiovascular Center
2011-2012
Central Research Institute
2007-2009
Longitudinal bone growth is determined by endochondral ossification that occurs as chondrocytes in the cartilaginous plate undergo proliferation, hypertrophy, cell death, and osteoblastic replacement. The natriuretic peptide family consists of three structurally related endogenous ligands, atrial, brain, C-type peptides (ANP, BNP, CNP), thought to be involved a variety homeostatic processes. To investigate physiological significance CNP vivo , we generated mice with targeted disruption (...
Lack of leptin is implicated in insulin resistance and other metabolic abnormalities generalized lipodystrophy; however, the efficacy, safety, underlying mechanisms leptin-replacement therapy patients with lipodystrophy remain unclear.Seven Japanese lipodystrophy, two acquired five congenital type, were treated physiological replacement dose recombinant during an initial 4-month hospitalization followed by outpatient follow-up for up to 36 months.The twice-daily injection dramatically...
Longitudinal bone growth is determined by endochondral ossification at the plate, which located both ends of long bones and vertebrae, involves many systemic hormones local regulators. C-type natriuretic peptide (CNP), a third member family, occurs plate acts locally as positive regulator through intracellular accumulation cyclic GMP (cGMP). The increase in cGMP concentrations known to activate different signaling mediators, such nucleotide phosphodiesterases, cGMP-regulated ion channels,...
Mitochondria are highly dynamic organelles continuously undergoing fission and fusion, referred to as mitochondrial dynamics, adapt nutritional demands. Evidence suggests that impaired dynamics leads metabolic abnormalities such non-alcoholic steatohepatitis (NASH) phenotypes. However, how involved in the development of NASH is poorly understood. This study aimed elucidate role factor (MFF) NASH.We created mice with hepatocyte-specific deletion MFF (MffLiKO). MffLiKO fed normal chow diet...
There has been a concern that sodium-glucose cotransporter 2 (SGLT2) inhibitors could reduce skeletal muscle mass and function. Here, we examine the effect of canagliflozin (CANA), an SGLT2 inhibitor, on slow fast muscles from nondiabetic C57BL/6J mice. In this study, mice were fed with or without CANA under ad libitum feeding, then evaluated for metabolic valuables as well We also examined gene expressions metabolites in muscles. During inhibition, function is increased, accompanied by...
Angiopoietin-like protein (ANGPTL)8 is a liver- and adipocyte-derived that controls plasma triglyceride (TG) levels. Most animal studies have used mouse models. Here, we generated an Angptl8 KO rat model using clustered regulatory interspaced short palindromic repeat (CRISPR)/CRISPR-associated 9 (Cas9) (CRISPR/Cas9) system to clarify the roles of ANGPTL8 in glucose lipid metabolism. Compared with WT rats, rats had lower body weight fat content, associated impaired lipogenesis adipocytes; no...
Abstract Primary aldosteronism (PA) is associated with an increased risk of cardiometabolic diseases, especially in unilateral subtype. Despite its high prevalence, the case detection rate PA limited, partly because no clinical models available general practice to identify patients highly suspicious subtype PA, who should be referred specialized centers. The aim this retrospective cross-sectional study was develop a predictive model for diagnosis based on machine learning methods using data...
Bone morphogenetic protein-3b (BMP-3b) is a member of the transforming growth factor-β (TGF-β) superfamily. BMP-3b regulates osteogenesis and has critical roles in developing embryos. expressed not only bone embryos but also adipose tissues. However, functions tissue are still unknown. expression was quantified various tissues adipose-derived stromal-vascular fraction (SVF) mature adipocyte (AD.F) mice. We used 3T3-L1 preadipocytes to analyze expression, function molecular forms BMP-3b. In...
Congenital generalized lipodystrophy (CGL), Berardinelli-Seip syndrome, is a rare metabolic disorder characterized by near total lack of adipose tissue from birth or early infancy. Recently, seipin, encoding 398-amino acid protein unknown function, and AGPAT2, 1-acyl-sn-glycerol-3-phosphate acyltransferase 2, were identified as causative genes for CGL. Seipin mutations found in patients families originating Europe the Middle East. AGPAT2 predominantly African ancestry. However, no...
BackgroundThe human adrenal cortex consists of three functionally and structurally distinct layers; zona glomerulosa, fasciculata (zF), reticularis (zR), produces steroid hormones in a layer-specific manner; aldosterone, cortisol, androgens, respectively. Cortisol-producing adenomas (CPAs) occur mostly as result somatic mutations associated with the protein kinase A pathway. However, how CPAs develop after adrenocortical cells acquire genetic mutations, remains poorly understood.MethodsWe...
Factors affecting auditory improvement after stapes surgery were investigated retrospectively on a study group of 106 otosclerotic ears (86 subjects). While the closure air-bone (A-B) gap was good at 2 kHz and 4 kHz, it poor 8 frequencies lower than 1 kHz. Under frequency, worse A-B surgery. Stapedotomy partial stapedectomy showed better post-operative hearing gain total stapedectomy. Total scored significantly 250 Hz 500 stapedotomy. There close relationship between pre-operative under The...
Brain natriuretic peptide (BNP), a hormone produced primarily by the cardiac ventricle, is thought to be involved in variety of homeostatic processes through its cognate receptor, guanylyl cyclase A (GC-A). We previously created transgenic mice overexpressing BNP under control liver-specific human serum amyloid P component promoter (BNP-transgenic mice) and demonstrated that they exhibit reduced blood pressure weight accompanied an elevation plasma cGMP concentrations marked skeletal...
Abstract Context Current clinical guidelines recommend confirmation of a positive result in at least one confirmatory test the diagnosis primary aldosteronism (PA). Clinical implication multiple tests has not been established, especially when patients show discordant results. Objective The aim present study was to explore role 2 subtype PA. Design and Setting A retrospective cross-sectional conducted two referral centers. Participants Methods We identified 360 hypertensive who underwent both...
Eustachian tube (ET) function was studied by means of sonotubometry and tubotympano-aerodynamography (TTAG) prior to following exposure hypobaric or hyperbaric conditions. Forty normal adults were subjected pressure. Fifty who underwent oxygen (HBO) therapy also studied. Following exposure, 14 80 ears (17.5%) exhibited middle ear barotrauma. 34 100 (34%) Dysfunction the ET, characterized altered active passive opening capacity, more prevalent extremes in atmospheric pressure compared...
A high-fat diet (HFD) is a well-known contributing factor in the development of obesity. Most rats fed HFDs become obese. Those that avoid obesity when are considered resistant (DR). We performed microarray screen to identify genes specific mesenteric fat DR and revealed high expression guanylin guanylyl cyclase C (GC-C) some subjects. Our histologic studies cellular source GC-C macrophages. Therefore, we developed double-transgenic (Tg) overexpressing macrophages found they were effects...
Abstract Background Diabetes is associated with an increased risk of deleterious changes in muscle mass and function or sarcopenia, leading to physical inactivity worsening glycaemic control. Given the negative energy balance during sodium–glucose cotransporter‐2 (SGLT2) inhibition, whether SGLT2 inhibitors affect skeletal a matter concern. However, how inhibition affects patients diabetes remains insufficiently explored. We aimed explore effects canagliflozin (CANA), inhibitor, on muscles...