A5013425344- Marine animal studies overview
- Arctic and Antarctic ice dynamics
- Topic Modeling
- Advanced Text Analysis Techniques
- Natural Language Processing Techniques
- Cancer Cells and Metastasis
- Underwater Acoustics Research
- Marine and coastal plant biology
- Sentiment Analysis and Opinion Mining
- Speech and dialogue systems
- Hormonal Regulation and Hypertension
- Animal Vocal Communication and Behavior
- Cancer Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Coral and Marine Ecosystems Studies
- Organ Transplantation Techniques and Outcomes
- Immune Response and Inflammation
- Adipose Tissue and Metabolism
- Inflammatory Bowel Disease
- Drug Transport and Resistance Mechanisms
- High-Temperature Coating Behaviors
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
Okinawa Churashima Foundation
2016-2025
Hokkaido University
2013-2024
Tokyo Institute of Technology
2024
National Institute of Infectious Diseases
2024
NTT (Japan)
2002-2023
Hokkaido University of Science
2021
Fukuoka University
2018
Tokyo University of Marine Science and Technology
2015-2017
Okinawa Prefecture
2017
Kyushu University
2017
For the 40 years after end of commercial whaling in 1976, humpback whale populations North Pacific Ocean exhibited a prolonged period recovery. Using mark–recapture methods on largest individual photo-identification dataset ever assembled for cetacean, we estimated annual ocean-basin-wide abundance species from 2002 through 2021. Trends estimates describe strong post-whaling era population recovery 16 875 (± 5955) to peak estimate 33 488 4455) 2012. An apparent 20% decline 2012 2021, 26 662...
Lack of leptin is implicated in insulin resistance and other metabolic abnormalities generalized lipodystrophy; however, the efficacy, safety, underlying mechanisms leptin-replacement therapy patients with lipodystrophy remain unclear.Seven Japanese lipodystrophy, two acquired five congenital type, were treated physiological replacement dose recombinant during an initial 4-month hospitalization followed by outpatient follow-up for up to 36 months.The twice-daily injection dramatically...
Abstract Hepatocellular carcinoma ( HCC ) is a highly prevalent cancer with poor prognosis. The correlation between overexpression of fatty acid‐binding protein 5 FABP 5) and malignant potential tumor growth metastasis in several cancers has been previously reported. However, the expression behavior remains unknown. We compared patient characteristics paired adjacent noncancerous liver tissues from 243 patients who underwent surgical resection primary . Cell proliferation, invasion,...
近年, web上に多数存在する掲示板などの文書から, 意見を自動的に収集・解析する技術への関心が高まっている.このような意見情報の抽出には, 評価を表す表現が重要な手がかりとなるが, それらの表現には「燃費がよい」「CGがきれい」といった領域依存の表現が多数存在するため, 人手で書き尽くすことは困難である.そこで, 我々は, 評価対象表現, 属性表現, 評価表現の共起情報を利用して, これら領域依存の表現を効率的に収集することを試みた.本稿では, 共起パタンに基づく属性・評価値表現の半自動的収集方法を提案し, 「コンピュータ」と「ゲーム」の2つの領域を対象に, 人手と提案手法で行なった収集効率実験の結果について報告する.
Male humpback whales ( Megaptera novaeangliae ) sing a slowly evolving, sexually selected song display socially learned from conspecifics. Within an ocean basin, similarity between breeding populations can reveal the degree of connectivity among them. In northwestern Pacific Ocean, there is paucity information on dynamics and linkages across basin. Here, we quantified fine-scale evolution in near Okinawa, Japan, using indices (Levenshtein distance Dice’s similarity) complexity measures to...
Abstract Purpose: The purpose of this research was to identify molecular clues tumor progression and lymph node metastasis in esophageal cancer test their value as predictive markers. Experimental Design: We explored the gene expression profiles cDNA array data a 36-tissue training set squamous cell carcinoma (ESCC) by using generalized linear model-based regression analysis feature subset selection algorithm. By applying identified optimal sets (predictive sets), we trained developed...
In inflammatory bowel disease (IBD), gut inflammation is associated with the activation of nuclear factor kappa B (NF-κB), a key pro-inflammatory transcription factor.To investigate therapeutic potential novel, specific NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), we examined its effect on IBD using murine experimental colitis models.The in vitro DHMEQ was evaluated by cytokine production and p65 immunostaining HT-29 RAW264.7 cells. The vivo studied induced dextran sulphate...
We present an ocean-basin-scale dataset that includes tail fluke photographic identification (photo-ID) and encounter data for most living individual humpback whales (Megaptera novaeangliae) in the North Pacific Ocean. The was built through a broad collaboration combining 39 separate curated photo-ID catalogs, supplemented with community science data. Data from throughout were aggregated into 13 regions, including six breeding feeding one migratory corridor. All images compared minimal...
Leptin augments glucose and lipid metabolism independent of its effect on satiety. Administration leptin in rodents increases skeletal muscle beta-oxidation by activating AMP-activated protein kinase (AMPK). We previously reported that, as hyperleptinemic obese human subjects, transgenic skinny mice overexpressing liver (LepTg) exhibit enhanced insulin sensitivity clearance. To assess AMPK activity leptin-sensitive -insensitive states, we examined phosphorylation target, acetyl CoA...
The task of opinion extraction and structurization is the key component mining, which allow Web users to retrieve summarize people's opinions scattered over Internet. Our aim develop a method for extracting that represent evaluation concumer products in structured form. To achieve goal, we need consider some issues are relevant task: How should be designed, how extract defined. We define an unit consisting quadruple, is, holder, subject being evaluated, part or attribute it expresses...
Macrophage infiltration in obese adipose tissue provokes local inflammation and insulin resistance. Evidence has accumulated that activation of 11β‐HSD1 adipocytes is critically involved dysfunction tissue. However, the potential role macrophages still remains unclear. We here demonstrate a murine macrophage cell line, J774.1 cells expressed mRNA reductase activity, both which were augmented by lipopolysaccharide (LPS)‐induced activation. Three kinds pharmacological inhibition LPS‐treated...
Abstract Background Cancer cells can alter glucose metabolism and regulate the expression of transporters. Hepatoblastoma patients undergo cisplatin‐based chemotherapy; however, 22.3% develop cisplatin resistance thus face a poor prognosis. We hypothesized that transporters are associated with acquiring increasing sugar intake inhibiting could reduce in hepatoblastoma patients. Methods established cisplatin‐resistant HepG2 HuH6 by continuous treatment cisplatin. evaluated relationship...
Congenital generalized lipodystrophy (CGL), Berardinelli-Seip syndrome, is a rare metabolic disorder characterized by near total lack of adipose tissue from birth or early infancy. Recently, seipin, encoding 398-amino acid protein unknown function, and AGPAT2, 1-acyl-sn-glycerol-3-phosphate acyltransferase 2, were identified as causative genes for CGL. Seipin mutations found in patients families originating Europe the Middle East. AGPAT2 predominantly African ancestry. However, no...
Gold magnetic particles (GMP) are iron oxide modified with gold nanoparticles. The of GMP specifically bind to cysteine and methionine through Au–S binding. aim the present study was establish a quick easy protein purification system using novel peptide tags GMP. Here, we created variety containing analyzed their affinity Binding assays enhanced green fluorescent (EGFP) as model indicated that tandem comprising residues had higher than both residues. Tags glycine showed slightly elution...
Three guns based on different thermal spray technologies—namely, gas flame spray, wire arc and plasma spray—were operated at each best cost–performance condition, the resulting droplets deposited coating qualities were investigated. For former, a simple optical monitoring system was used to measure temperatures velocities of ejected from guns. On other hand, for latter, layers substrates—namely, surface roughness, atomic composition, hardness, adhesive strength, porosity—were characterized....
Abstract Humpback whales migrate seasonally from high latitude feeding areas to lower breeding for mating and calving. In 2004–2006, a North Pacific basin‐wide study called SPLASH was conducted as an international collaboration among various groups of researchers. The Russian Far East consists multiple during , 102 were identified compared catalogs areas. Our goal in this further investigate the migratory destinations using total 1,459 photographs 2004 2014. We latest catalog with wintering...