A5004749761- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Organ Transplantation Techniques and Outcomes
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Metastasis and carcinoma case studies
- Liver physiology and pathology
- Genetic and Kidney Cyst Diseases
- Renal cell carcinoma treatment
- Cancer Mechanisms and Therapy
- Gastric Cancer Management and Outcomes
- Viral-associated cancers and disorders
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Multiple and Secondary Primary Cancers
- Pancreatitis Pathology and Treatment
- Wnt/β-catenin signaling in development and cancer
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
Hokkaido University
2015-2024
The Japanese Society of Gastroenterological Surgery
2024
Hokkaido University Hospital
2017-2023
Hokkaido University of Science
2020-2021
Scripps Green Hospital
2014
Brown University
2014
Rhode Island Hospital
2014
Icahn School of Medicine at Mount Sinai
2014
Keimyung University
2014
Asahikawa Kosei Hospital
2011-2014
Abstract Background and Aim Combined hepatocellular–cholangiocarcinoma (CHC) is a primary liver cancer containing both hepatocellular carcinoma (HCC) intrahepatic cholangiocarcinoma (ICC) elements. Its reported clinicopathological features prognoses have varied because of its low prevalence. This study aimed to clarify these aspects CHC. Methods We enrolled 28 patients with CHC, 1050 HCC, 100 ICC compared the characteristics prognosis CHC HCC ICC. also analyzed prognostic factors, recurrence...
Abstract Hepatocellular carcinoma ( HCC ) is a highly prevalent cancer with poor prognosis. The correlation between overexpression of fatty acid‐binding protein 5 FABP 5) and malignant potential tumor growth metastasis in several cancers has been previously reported. However, the expression behavior remains unknown. We compared patient characteristics paired adjacent noncancerous liver tissues from 243 patients who underwent surgical resection primary . Cell proliferation, invasion,...
Abstract Histological differentiation is a major pathological parameter associated with poor prognosis in patients hepatocellular carcinoma (HCC) and the molecular signature underlying HCC may involve key proteins potentially affecting malignant characters of HCC. To develop prognostic biomarkers for HCC, we examined global protein expression profiles 45 surgically resected tissues, including 27 HCCs different degree histological differentiation, 11 adjacent nontumor seven normal liver...
Background and Objectives This study aimed to evaluate the impact of huge (≥10 cm) hepatocellular carcinoma (HCC) recurrence pattern prognosis after hepatectomy. Methods 574 patients who underwent hepatectomy by 17 surgeons (Open 536 Laparoscopic 38) for HCC without major vascular invasion from 1990 2013 at single institute were retrospectively analyzed. Results Huge tumor, age, HCV, multiple tumors microscopic portal are independent risk factors overall survival (OS), ICGR15 ≥16%, tumors,...
The purpose of this study was to evaluate the results hepatectomy with inferior vena cava or hepatic vein resection, followed by vessel reconstruction an artificial vascular graft.From 2000 2011, 1,434 patients underwent several types at our institution. Of these, we reviewed cases eight (0.56%) who resection and subsequent using expanded polytetrafluoroethylene (PTFE) graft.We resected in six two patients. All PTFE graft. median operative time 443 minutes blood loss 2,017 mL. postoperative...
Abstract Background Intrahepatic cholangiocarcinoma (ICC) has a high recurrence rate and poor prognosis. Thus, the development of effective treatment prognostic biomarkers is required. High expression diacylglycerol kinase alpha (DGKα) factor for hepatocellular carcinoma. However, relationship between DGKα prognosis in ICC not been reported. Methods Immunohistochemistry (IHC) with anti‐DGKα antibody was performed on surgical specimens ( n = 69). First, cancer cells qualitatively classified...
Because hepatectomy is not recommended in patients with stage B hepatocellular carcinoma (HCC) of the Barcelona Clinic Liver Cancer (BCLC) staging, we evaluated survival outcomes for BCLC system. Data were collected from 297 consecutive adult who underwent curative HCC between 1996 and 2014 Hokkaido University Hospital. Overall (OS), disease-free (DFS), risk factors analyzed using Kaplan–Meier method. Independent prognostic a Cox proportional hazards regression model. AP-factor...
To evaluate the oncological implications of multiplication α-fetoprotein (AFP) and protein induced by vitamin K absence or antagonists-II (PIVKA-II) in patients with hepatocellular carcinoma (HCC).Data were prospectively collected from 516 consecutive who underwent a curative primary hepatectomy for HCC between 1998 2010. The AP-factor (AFP × PIVKA-II) was evaluated relation to 2-year survival outcomes receiver-operator curve analysis determine cut-off values. Patient survival,...
Abstract Objectives The aim was to evaluate the prognostic factors, clinicopathological characteristics, and surgical outcomes after hepatectomy in very elderly patients with hepatocellular carcinoma (HCC). Methods We analyzed 796 HCC from 2000 2017. Patients aged 80 years or older were classified into group (group VE; n = 49); younger than old 65 E; 363), young Y; 384). investigated prognoses, hepatectomy. Results number of procedures outcomes, including morbidities, not significantly...
Abstract Aim To report the outcomes of stereotactic body radiotherapy using a real‐time tumor‐tracking system for hepatocellular carcinoma patients. Methods From January 2005 to July 2018, 63 patients with 74 lesions maximum diameter ≤52 mm were treated by system. No patient Child–Pugh Score ≥9 was included, and 85.6% had score 5 or 6. Using biological effective dose (BED) an α/β ratio 10 (BED ), median in BED at reference point 76.8 Gy (range 60–122.5 Gy). Overall survival (OS) local...
This study aims at establishing benchmark values for best achievable outcomes following open major anatomic hepatectomy liver tumors of all dignities.
Percutaneous transhepatic portal embolization (PTPE) is useful for safe major hepatectomy. This study investigated the correlation between hepatic hypertrophy and hemodynamics of venous flow by ultrasound sonography after PTPE. We analyzed 58 patients with PTPE, excluding those who underwent recanalization (n = 10). Using CT volumetry results 2 weeks were stratified into a considerable group (CH; n 15) an increase rate remnant liver volume (IR-RLV) ≥ 40% minimal (MH; 33) IR-RLV < 40%. PTPE...
AIM:To evaluate the usefulness of functional hepatic resection rate (FHRR) calculated using 3D computed tomography (CT)/ 99m Tc-galactosyl-human serum albumin (GSA) single-photon emission (SPECT) fusion imaging for surgical decision making. METHODS:We enrolled 57 patients who underwent bi-or trisectionectomy at our institution between October 2013 and March 2015.Of these, 26 presented with hepatocellular carcinoma, 12 hilar cholangiocarcinoma, six intrahepatic four liver metastasis, nine...
Aim A new classification of combined hepatocellular cholangiocarcinoma (CHC) was recently reported. Cancer stem cells have been associated with CHC carcinogenesis. This study examined the association cancer cell marker expression and prognosis in classified using classification. Methods We enrolled 26 patients them according to evaluated markers (CD56, CD133, epithelial adhesion molecule [EpCAM]) by immunohistochemical staining each component. analyzed between expressions prognosis. Results...
Abstract Background We assessed the usefulness of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid enhanced magnetic resonance imaging for prediction posthepatectomy liver failure (PHLF) after a major hepatectomy. Methods reviewed 140 cases involving hepatectomy two or more sections between 2010 and 2016 (study cohort). used standardized remnant hepatocellular uptake index (SrHUI) which was calculated by: SrHUI = future volume × [(signal intensity on hepatobiliary phase...
Background: Currently, the population with type 2 diabetes mellitus (DM) is increasing worldwide. However, influence of DM or hyperglycemia on outcome resected hepatocellular carcinoma (HCC) unclear.